Dr. S.L. (Sylvie) Lesuis PhD
Faculteit der Natuurwetenschappen, Wiskunde en Informatica
Education Service Centre
Bezoekadres
- Science Park 904
- Kamernummer: C3.103
Postadres
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Postbus 94214
1090 GE Amsterdam
Contactgegevens
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Publicaties
2025
Lesuis, S. L., Park, S., Hoorn, A., Rashid, A. J., Mocle, A. J., Salter, E. W., Vislavski, S., Gray, M. T., Torelli, A. M., DeCristofaro, A., Driever, W. P. F., van der Stelt, M., Zweifel, L. S., Collingridge, G. L., Lefebvre, J. L., Walters, B. J., Frankland, P. W., Hill, M. N., & Josselyn, S. A. (2025). Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice. Cell, 188(1), 121-140.e20. https://doi.org/10.1016/j.cell.2024.10.034 [details]- Lesuis, S. L., Rashid, A. J., Hoorn, A., Park, S., Mocle, A. J., Torelli, A. M., DeCristofaro, A., Frankland, P. W., Hill, M. N., & Josselyn, S. A. (2025). Protocol to visualize three distinct neuronal ensembles encoding different events in the mouse brain using genetic and viral approaches. STAR Protocols, 6(2), Article 103747. https://doi.org/10.1016/j.xpro.2025.103747 [details]
- Lucassen, P. J., Korosi, A., de Rooij, S. R., Smit, A. B., Van Dam, A.-M., Daskalakis, N. P., Van Kesteren, R. E., Verheijen, M. H. G., Lesuis, S. L., Kessels, H. W., & Krugers, H. J. (2025). How Can Early Stress Influence Later Alzheimer's Disease Risk? Possible Mediators and Underlying Mechanisms. Biological Psychiatry, 97(4), 372-381. https://doi.org/10.1016/j.biopsych.2024.11.007 [details]
- Willems, T. S., Xiong, H., Kessels, H. W., & Lesuis, S. L. (2025). GluA1-containing AMPA receptors are necessary for sparse memory engram formation. Neurobiology of Learning and Memory, 218, Article 108031. https://doi.org/10.1016/j.nlm.2025.108031 [details]
2024
- Brosens, N., Lesuis, S. L., Rao-Ruiz, P., van den Oever, M. C., & Krugers, H. J. (2024). Shaping Memories via Stress: A Synaptic Engram Perspective. Biological Psychiatry, 95(8), 721-731. https://doi.org/10.1016/j.biopsych.2023.11.008 [details]
- Kotah, J. M., Kater, M. S. J., Brosens, N., Lesuis, S. L., Tandari, R., Blok, T. M., Marchetto, L., Yusaf, E., Koopmans, F. T. W., Smit, A. B., Lucassen, P. J., Krugers, H. J., Verheijen, M. H. G., & Korosi, A. (2024). Early-life stress and amyloidosis in mice share pathogenic pathways involving synaptic mitochondria and lipid metabolism. Alzheimer's & Dementia, 20(3), 1637-1655. https://doi.org/10.1002/alz.13569 [details]
2023
- Brosens, N., Lesuis, S. L., Bassie, I., Reyes, L., Gajadien, P., Lucassen, P. J., & Krugers, H. J. (2023). Elevated corticosterone after fear learning impairs remote auditory memory retrieval and alters brain network connectivity. Learning & Memory, 30(7), 125-132. https://doi.org/10.1101/lm.053836.123 [details]
2022
- Sanguino-Gómez, J., Buurstede, J. C., Abiega, O., Fitzsimons, C. P., Lucassen, P. J., Eggen, B. J. L., Lesuis, S. L., Meijer, O. C., & Krugers, H. J. (2022). An emerging role for microglia in stress-effects on memory. European Journal of Neuroscience, 55(9-10), 2491-2518. https://doi.org/10.1111/ejn.15188 [details]
2021
- Lesuis, S. L., Brosens, N., Immerzeel, N., van der Loo, R. J., Mitrić, M., Bielefeld, P., Fitzsimons, C. P., Lucassen, P. J., Kushner, S. A., van den Oever, M. C., & Krugers, H. J. (2021). Glucocorticoids Promote Fear Generalization by Increasing the Size of a Dentate Gyrus Engram Cell Population. Biological Psychiatry, 90(7), 494-504. https://doi.org/10.1016/j.biopsych.2021.04.010 [details]
- Lesuis, S. L., Lucassen, P. J., & Krugers, H. J. (2021). Early life stress amplifies fear responses and hippocampal synaptic potentiation in the APPswe/PS1dE9 Alzheimer mouse model. Neuroscience, 454, 151-161. https://doi.org/10.1016/j.neuroscience.2019.07.012 [details]
2020
- Lesuis, S. L., Timmermans, W., Lucassen, P. J., Hoogenraad, C. C., & Krugers, H. J. (2020). Glucocorticoid and β-adrenergic regulation of hippocampal dendritic spines. Journal of Neuroendocrinology, 32(1), Article e12811. https://doi.org/10.1111/jne.12811 [details]
2019
- Lesuis, S. L., Kaplick, P. M., Lucassen, P. J., & Krugers, H. J. (2019). Treatment with the glutamate modulator riluzole prevents early life stress-induced cognitive deficits and impairments in synaptic plasticity in APPswe/PS1dE9 mice. Neuropharmacology, 150, 175-183. https://doi.org/10.1016/j.neuropharm.2019.02.023 [details]
- Lesuis, S. L., Lucassen, P. J., & Krugers, H. J. (2019). Early life stress impairs fear conditioning memory and synaptic plasticity; a potential role for GluN2B. Neuropharmacology, 149, 195-203. https://doi.org/10.1016/j.neuropharm.2019.01.010 [details]
2018
- Hoeijmakers, L., Lesuis, S. L., Krugers, H., Lucassen, P. J., & Korosi, A. (2018). A preclinical perspective on the enhanced vulnerability to Alzheimer's disease after early-life stress. Neurobiology of Stress, 8, 172-185. https://doi.org/10.1016/j.ynstr.2018.02.003 [details]
- Lesuis, S. L., Catsburg, L. A. E., Lucassen, P. J., & Krugers, H. J. (2018). Effects of corticosterone on mild auditory fear conditioning and extinction; role of sex and training paradigm. Learning & Memory, 25(10), 544-549. https://doi.org/10.1101/lm.047811.118 [details]
- Lesuis, S. L., Hoeijmakers, L., Korosi, A., de Rooij, S. R., Swaab, D. F., Kessels, H. W., Lucassen, P. J., & Krugers, H. J. (2018). Vulnerability and resilience to Alzheimer's disease: early life conditions modulate neuropathology and determine cognitive reserve. Alzheimer's Research & Therapy, 10, Article 95. https://doi.org/10.1186/s13195-018-0422-7 [details]
- Lesuis, S. L., Weggen, S., Baches, S., Lucassen, P. J., & Krugers, H. J. (2018). Targeting glucocorticoid receptors prevents the effects of early life stress on amyloid pathology and cognitive performance in APP/PS1 mice. Translational Psychiatry, 8, Article 53. https://doi.org/10.1038/s41398-018-0101-2 [details]
- Pillai, A. G., Arp, M., Velzing, E., Lesuis, S. L., Schmidt, M. V., Holsboer, F., Joëls, M., & Krugers, H. J. (2018). Early life stress determines the effects of glucocorticoids and stress on hippocampal function: Electrophysiological and behavioral evidence respectively. Neuropharmacology, 133, 307-318. Advance online publication. https://doi.org/10.1016/j.neuropharm.2018.02.001 [details]
2017
- Krugers, H. J., Arp, J. M., Xiong, H., Kanatsou, S., Lesuis, S. L., Korosi, A., Joels, M., & Lucassen, P. J. (2017). Early life adversity: Lasting consequences for emotional learning. Neurobiology of Stress, 6, 14-21. https://doi.org/10.1016/j.ynstr.2016.11.005 [details]
- Lesuis, S. L., van Hoek, B. A. C. E., Lucassen, P. J., & Krugers, H. J. (2017). Early postnatal handling reduces hippocampal amyloid plaque formation and enhances cognitive performance in APPswe/PS1dE9 mice at middle age. Neurobiology of Learning and Memory, 144, 27-35. https://doi.org/10.1016/j.nlm.2017.05.016 [details]
2016
- Lesuis, S. L., Maurin, H., Borghgraef, P., Lucassen, P. J., Van Leuven, F., & Krugers, H. J. (2016). Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer’s disease. Oncotarget, 7(26), 39118-39135. https://doi.org/10.18632/oncotarget.9776 [details]
2015
- Lucassen, P. J., Jacobs, E. H., Hoeijmakers, L., Lesuis, S. L., Krugers, H., Korosi, A., Kuhn, H. G., & Boekhoorn, K. (2015). Stem cells and neurogenesis in relation to Alzheimer's disease Models. In H. G. Kuhn, & A. J. Eisch (Eds.), Neural Stem Cells in Development, Adulthood and Disease (pp. 53-78). (Stem Cell Biology and Regenerative Medicine series). Human Press. https://doi.org/10.1007/978-1-4939-1908-6_4 [details]
2019
- Lucassen, P. J., Lesuis, S. L., Hoeijmakers, L., Yam, K. Y., Fitzsimons, C. P., Korosi, A., & Krugers, H. (2019). Brain plasticity in relation to (early life) stress, nutrition and dementia. Journal of Neural Transmission, 126(11), 1561-1562.
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Lesuis, S. L., Park, S., Hoorn, A., Rashid, A. J., Mocle, A. J., Salter, E. W., Vislavski, S., Gray, M. T., Torelli, A. M., DeCristofaro, A., Driever, W. P. F., van der Stelt, M., Zweifel, L. S., Collingridge, G. L., Lefebvre, J. L., Walters, B. J., Frankland, P. W., Hill, M. N., & Josselyn, S. A. (2025). Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice. Cell, 188(1), 121-140.e20.