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dhr. prof. dr. P.J. (Paul) Lucassen

Faculteit der Natuurwetenschappen, Wiskunde en Informatica
Swammerdam Institute for Life Sciences
Fotograaf: Paul Lucassen

Bezoekadres
  • Science Park 904
  • Kamernummer: C3.270
Postadres
  • Postbus 94246
    1090 GE Amsterdam
  • Lucassen group; "Plasticity of the Brain".
    Newborn neurons (white) in the adult rodent hippocampus (blue), image courtesy Dr B. Czeh.

    General information; research topics

    Our main interest is structural plasticity in relation to stress and disease. In addition to apoptosis, we focus on the regulation of adult neurogenesis and its relevance for cognition, depression and dementia. Neurogenesis is prominent particularly during early development, and our primary focus is effects of early stress on (development of) the hippocampus. This brain structure is very sensitive to stress hormone action, implicated in learning and memory and affected in both these disease conditions. The hippocampus is furthermore unique as it contains stem cells that continue to generate new neurons in adult animals, including humans, a process called "adult neurogenesis".
    Key interest is the functional relevance of adult neurogenesis for brain function. We are interested in whether blockade or normalization of stress effects on neurogenesis in adult life can be beneficial in terms of e.g. recovery from depression. We hypothesize that e.g. stress-inducedreductions in the number of newborn neurons is deterined during early development and will interfere with the role of the hippocampus e.g. in cognition and in negative feedback of the HPA-axis in adult life. We further study how such deficits can be influenced and possibly ameliorated by means of early diet, antidepressant treatment, or physical or cognitively challenging events such as life long learning and exercise.

    Personal websites:

    http://sils.uva.nl/sfpns

    Verwijzing

    Selected recent key publications;

    - PJ Lucassen, CP Fitzsimons, A Korosi, M Joels, C Belzung and DN Abrous. Stressing new neurons into depression? Mol Psychiatry 2013 18: 396-397.

    - C P Fitzsimons, L W A van Hooijdonk, M Schouten, I Zalachoras, V Brinks, T Zheng, T G Schouten, D J Saaltink, T Dijkmans, D A Steindler, J Verhaagen, F J Verbeek, P J Lucassen, E R de Kloet, O C Meijer, H Karst, M Joels, M S Oitzl and E Vreugdenhil. Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior. Mol Psychiatry 2013 18: 993-1005.

    - I Zalachoras, R Houtman, E Atucha, R Devos, AMI Tijssen, P Hu, P Lockey, NA Datson, J Belanoff , PJ Lucassen, M Joëls, ER de Kloet, B Roozendaal, H Hunt, OC Meijer. Differential Targeting of Brain Stress Circuits with a Selective Glucorticoid Receptor Modulator. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7910-5.

    - Paul J. Lucassen, Eva F.G. Naninck, Johannes B. van Goudoever, Carlos Fitzsimons, Marian Joels and Aniko Korosi. Perinatal programming of hippocampal structure and function; emerging roles of stress, neurogenesis, epigenetics and early nutrition. Trends in Neuroscience, 2013.

    - PJ Lucassen, N Sousa, OFX Almeida, G Rajkowska, J Pruessner, DF Swaab and B Czeh. Neuropathology of Stress. Acta Neuropathologica, 2014.

    - A. Schrantee, G.H. Tamminga, C. Bouziane, M.A. Bottelier, E.E. Bron, H.J.M. Mutsaerts, K. Zwinderman, I.R. Groote, S.A.R.B. Rombouts, R.J.L. Lindauer, W. Niessen, S. Klein, B.C. Opmeer, F. Boer, P.J. Lucassen, S.L. Andersen, H.M. Geurts and L. Reneman. A randomized trial on the age-dependency of methylphenidate effects on the human dopamine system. JAMA Psychiatry, 2016; 73(9):955-62.

    - SL Lesuis, H Maurin, P Borghgraef, PJ Lucassen, F Van Leuven, HJ Krugers. Positive and negative early life experiences differentially modulate longterm survival and amyloid protein levels in a mouse model of Alzheimer’s disease. Oncotarget. 2016 Jun 1. doi: 10.18632/oncotarget.9776.

    - E.F.G. Naninck, J.E. Oosterink, K.Y.Yam, L. de Vries, H. Schierbeek, J.B. van Goudoever, R.N. Verkaik-Schakel, J.A. Plantinga, T. Plosch, P.J. Lucassen and A. Korosi. Early micronutrient supplementation protects against early stress induced cognitive impairments. The FASEB Journal, 2017 Feb;31(2):505-518, DOI 10.1096/fj.201600834R.

    - Kit Y. Yam, E.F.G. Naninck, M.R. Abbink, S.E. la Fleur, L. Schipper, J.C. van den Beukel, A. Grefhorst, A. Oosting, E.M. van der Beek, P.J. Lucassen, A. Korosi. Exposure to chronic early-life stress lastingly alters the adipose tissue, the leptin system and changes the vulnerability to western-style diet later in life in mice. Psychoneuroendocrinology 77 (2017) 186–195.

    -SL Lesuis, S Weggen, S Baches, PJ Lucassen, HJ Krugers. Early life stress accelerates amyloid pathology and cognitive decline in an Alzheimer mouse model, which can be rescued by briefly blocking glucocorticoid receptors at middle age. Translational Psychiatry, in press, 2018.

     

    Video link to Paul Lucassen on Adult Neurogenesis (YouTube);

    http://www.youtube.com/watch?v=RI92wpnSkUU

     

    Paul Lucassen on Stem Cells and Neurogenesis

    Publications of PJ Lucassen on PubMed

  • Recent lectures, outreach, etc

    Lectures delivered;

    2015;
    1.    Invited Lecture "Structural plasticity in relation to (early) stress, nutrition and depression." Host; Dr. S. Schwarzacher, Dept Klinische NeuroAnatomie, Goethe Universitat, Frankfurt am Main, Germany, 15 Jan 2015.
    2.    Lecture; 'Trends in Alzheimer's disease research, a personal perspective' at the ISAO Meet and Greet meeting, Jaarbeurs Utrecht, 28 Jan 2015.
    3.    Invited Lecture "Effects of early life stress and nutrition on adult hippocampal plasticity and function" at MRC Social, Genetic and Developmental Psychiatry Centre (host; Dr Geoff Bird), Institute of Psychiatry, King's College London, United Kingdom, 16 Feb 2015.
    4.    Lecture 'Plasticity in relation to stress and neurogenesis'. Host; Dr Sandrine Thuret, King's College London, United Kingdom, Febr 17th 2015.
    5.    Invited Lecture 'Structural plasticity in relation to (early) stress, depression and dementia', at the Department of Fundamental Neurosciences, University of Lausanne  (host; Dr. N. Toni), Lausanne, Switzerland, 4th march 2015.
    6.    Invited lecture 'Hippocampal plasticity in relation to early stress, nutrition and depression', at the Department of Anatomy, ETH (hosts; Dr I Amrein, M Van Dijk), Zurich, Switzerland, 4th March 2015.
    7.    Invited Lecture "Structural plasticity in relation to (early) stress and depression", at the session on "Structural dynamics of adult neurogenesis" at the 17th International Neuroscience Winter Conference (host; Dr. S. Schwarzarcher), Solden, Switzerland, 10 April 2015.
    8.    Lecture "Structural plasticity, (early) stress, antidepressants and major depression", at the minisymposium on the occasion of the visit of Dr Snezana Milanovic at the AMC, Amsterdam, 28 may 2015.
    9.    Invited Lecture 'Application of MRS as tool to measure adult neurogenesis in the live human brain', ABC conference, Theater De Brakke Grond, Amsterdam, 1 Juni 2015.
    10.    Invited lecture 'Science matters; stress & stem cells', at the Biomedical Symposium Radboud Universiteit Nijmegen, 1 juli 2015. 
    11.    Invited lecture "Hippocampal plasticity in relation to (early) stress, nutrition and depression', at the Adult Neurogenesis meeting, Provence, France, 17 Sept 2015.
    12.    ECNP supported, plenary lecture at the 8th Simposium Psiquiatria de Braga; 'Structural plasticity in relation to early stress, nutrition and depression' at the University of Minho, Braga, Portugal, Oct 1st 2015.
    13.    Invited lecture’ ‘'Hippocampal plasticity in relation to early stress, nutrition and depression’ at the symposium on PTSD in Bristol, UK, hosts; Prof.Dr. Hans Reul, Prof.Dr. Astrid Linthorst, 16/17 November 2015.
    14.    Invited Plenary Lecture "Nieuwe cellen in het volwassen brein; stamcellen en sport" (laymen talk in Dutch) at the Opening Symposium of the "Exercise and the brain" week (supported by the Cruyff foundation) at the Amstelveen College, Amstelveen The Netherlands, 15 Dec 2015.

    2016;
    15.    Invited lecture 'Plasticity changes in relation to (early) stress, depression and dementia, at the Danish Academy, Aarhus University, Aarhus, Denmark, 14 jan 2016. 
    16.    Invited lecture 'Hippocampal plasticity in relation to early stress, nutrition and depression", at the 2016 IBRO Workshop, organized by the Hungarian Academy of Sciences, opening lecture of the symposium “Behavioral, Endocrine and Neuropathological Consequences of Stressful Life Events”. Budapest, Hungary, January 22nd, 2016. 
    17.    Invited Plenary lecture 'Ins and outs of Adult Neurogenesis', at the 5th Biennial ICCTF Meeting, Netherlands Cancer Institute Amsterdam, 15th March 2016 (host; Dr. S. Schagen).
    18.    Invited participant/discussant for the Round Table Expert meeting on Early Life Stress, at the 'Neurobiology of Stress' conference, 12-14 april in Newport Beach, Irvine, USA (host; Prof.Dr. T. Baram).
    19.    Invited lecture 'Structural plasticity and neurogenesis in relation to (early) stress, depression and dementia', Department of Neuroscience, Universitat de Valencia, Valencia, Spain, April 25th 2016 (host; Dr. J. Nacher). 
    20.    Invited Plenary Lecture "New neurons in adult brains; an emerging substrate for brain plasticity programmed during early life", at the Spring conference on 'Neuroplasticity & Cognitive Reserve' of the Dutch Association for NeuroPsychology, 13 may 2016, (host; Prof.Dr. B. Schmand), Muntgebouw Utrecht, the Netherlands.
    21.    Invited 'University of Amsterdam' lecture (in Dutch); 'Nieuwe zenuwcellen voor het volwassen brein', at the Universiteitsdag, Oudemanhuispoort, June 4th 2016, Amsterdam.
    22.    Invited talk 'Early stress and neurogenesis; the importance of nutritional programming for later cognition', at the 3rd EUROGENESIS meeting, July 12-15th 2016, Bordeaux, France.
    23.    Invited talk "(Early) stress effects on neurogenesis and plasticity", at the meeting of the British Psychiatry Association (BAP), Brighton UK, 17-20 July 2016.
    24.    Invited lecture; "Hippocampal plasticity, (early) stress and depression" at the ISPNE meeting in Miami, USA. 12 Sept 2016.
    25.    Invited Keynote speaker on 'Neurogenesis and Alzheimer", University Maastricht, 2 Dec 2016.


    2017;
    26.    Invited Lecture "Structural hippocampal plasticity and neurogenesis in relation to dementia", at the Alzheimer Center of the VUMC Amsterdam, hosts; PJ Visser, P Scheltens, W van der Flier, 20 Jan 2017.
    27.    Lecture 'An overview of Alzheimer research; the state of the affairs (in Dutch)", at the Netherlands Institute for Brain Research NIN, 7 Feb 2017. 
    28.    Invited Lecture 'Structural plasticity in relation to depression and dementia', at the Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark (host; Prof. Dr. B. Finsen), Odense, Denmark, 9 March 2017. 
    29.    Invited lecture on 'Regulation of neurogenesis by stress and antidepressants' at the Varna meeting on 'Adult primate neurogenesis', Varna, Bulgaria, 20 may 2017.
    30.    Invited Lecture on 'Our brain under stress (in Dutch)', at the Pawlik Congres – 'Presteren onder Druk', georganiseerd door Pawlik Consultants, Dauphine, Amsterdam, 30 may 2017. 
    31.    Moderator/chair/introductory talk to the session on 'Exercise and psychiatric disease; should patients take the challenge?' at the ECNP meeting in Paris, France, Sept 2017.
    32.    Invited Lecture ‘New neurons in, and for, adult brains; environmental regulation and functional roles’, within the framework of an ERASMUS exchange program at the Athens University, 24th October 2017.
    33.    Invited Lecture ‘Stem cells, hippocampal neurogenesis, stress and depression’, at the Dept of Psychiatry, University of Athens (host; Dr M. Panayatocopolou), 25th Oct 2017.
    34.    Invited laymens talk on ‘Our brain under stress’ (in Dutch), for the crowdfunded project on ‘Stress and the heart’, awarded to Dr A. Schrantee’ at the AMC Amsterdam, 31 Oct 2017.

     

  • Publicaties

    2019

    • Bielefeld, P., Schouten, M., Meijer, G. M., Breuk, M. J., Geijtenbeek, K., Karayel, S., ... Fitzsimons, C. P. (2019). Co-administration of Anti microRNA-124 and -137 Oligonucleotides Prevents Hippocampal Neural Stem Cell Loss Upon Non-convulsive Seizures. Frontiers in Molecular Neuroscience, 12, [31]. https://doi.org/10.3389/fnmol.2019.00031 [details]
    • Lesuis, S. L., Kaplick, P. M., Lucassen, P. J., & Krugers, H. J. (2019). Treatment with the glutamate modulator riluzole prevents early life stress-induced cognitive deficits and impairments in synaptic plasticity in APPswe/PS1dE9 mice. Neuropharmacology, 150, 175-183. https://doi.org/10.1016/j.neuropharm.2019.02.023 [details]
    • Lesuis, S. L., Lucassen, P. J., & Krugers, H. J. (2019). Early life stress impairs fear conditioning memory and synaptic plasticity; a potential role for GluN2B. Neuropharmacology, 149, 195-203. https://doi.org/10.1016/j.neuropharm.2019.01.010
    • Lucassen, P. J., Toni, N., Kempermann, G., Frisen, J., Gage, F. H., & Swaab, D. F. (2019). Limits to human neurogenesis-really? Molecular Psychiatry. https://doi.org/10.1038/s41380-018-0337-5
    • Schrantee, A., Solleveld, M. M., Schwantje, H., Bruin, W. B., Mutsaerts, H-J. M., Adriaanse, S. M., ... Reneman, L. (2019). Dose-dependent effects of the selective serotonin reuptake inhibitor citalopram: A combined SPECT and phMRI study. Journal of Psychopharmacology, 269881119836229. https://doi.org/10.1177/0269881119836229
    • Yam, K-Y., Schipper, L., Reemst, K., Ruigrok, S. R., Abbink, M. R., Hoeijmakers, L., ... Korosi, A. (2019). Increasing availability of ω-3 fatty acid in the early-life diet prevents the early-life stress-induced cognitive impairments without affecting metabolic alterations. The FASEB Journal, 33, 5729–5740. https://doi.org/10.1096/fj.201802297R

    2018

    • Gao, S., Zhang, T., Jin, L., Liang, D., Fan, G., Song, Y., ... Swaab, D. F. (2018). CAPON Is a Critical Protein in Synaptic Molecular Networks in the Prefrontal Cortex of Mood Disorder Patients and Contributes to Depression-Like Behavior in a Mouse Model. Cerebral Cortex, 1-14. https://doi.org/10.1093/cercor/bhy254
    • Hoeijmakers, L., Amelianchik, A., Verhaag, F., Kotah, J., Lucassen, P. J., & Korosi, A. (2018). Early-Life Stress Does Not Aggravate Spatial Memory or the Process of Hippocampal Neurogenesis in Adult and Middle-Aged APP/PS1 Mice. Frontiers in Aging Neuroscience, 10, [61]. https://doi.org/10.3389/fnagi.2018.00061 [details]
    • Hoeijmakers, L., Lesuis, S. L., Krugers, H., Lucassen, P. J., & Korosi, A. (2018). A preclinical perspective on the enhanced vulnerability to Alzheimer's disease after early-life stress. Neurobiology of Stress, 8, 172-185. https://doi.org/10.1016/j.ynstr.2018.02.003 [details]
    • Hoeijmakers, L., Meerhoff, G. F., de Vries, J. W., Ruigrok, S. R., van Dam, A-M., van Leuven, F., ... Lucassen, P. J. (2018). The age-related slow increase in amyloid pathology in APP.V717I mice activates microglia, but does not alter hippocampal neurogenesis. Neurobiology of Aging, 61, 112-123. https://doi.org/10.1016/j.neurobiolaging.2017.09.013 [details]
    • Kempermann, G., Gage, F. H., Aigner, L., Song, H., Curtis, M. A., Thuret, S., ... Frisén, J. (2018). Human Adult Neurogenesis: Evidence and Remaining Questions. Cell Stem Cell, 23(1), 25-30. https://doi.org/10.1016/j.stem.2018.04.004 [details]
    • Lesuis, S. L., Catsburg, L. A. E., Lucassen, P. J., & Krugers, H. J. (2018). Effects of corticosterone on mild auditory fear conditioning and extinction; role of sex and training paradigm. Learning & Memory, 25(10), 544-549. https://doi.org/10.1101/lm.047811.118 [details]
    • Lesuis, S. L., Hoeijmakers, L., Korosi, A., de Rooij, S. R., Swaab, D. F., Kessels, H. W., ... Krugers, H. J. (2018). Vulnerability and resilience to Alzheimer's disease: early life conditions modulate neuropathology and determine cognitive reserve. Alzheimer's Research & Therapy, 10, [95]. https://doi.org/10.1186/s13195-018-0422-7 [details]
    • Lesuis, S. L., Weggen, S., Baches, S., Lucassen, P. J., & Krugers, H. J. (2018). Targeting glucocorticoid receptors prevents the effects of early life stress on amyloid pathology and cognitive performance in APP/PS1 mice. Translational Psychiatry, 8, [53]. https://doi.org/10.1038/s41398-018-0101-2 [details]
    • Meerhoff, G. F., Vester, S. M., Hesseling, P., Klaassen, S. D., Cornelissen, A. S., Lucassen, P. J., & Joosen, M. J. A. (2018). Potentiation of antiseizure and neuroprotective efficacy of standard nerve agent treatment by addition of tariquidar. Neurotoxicology, 68, 167-176. https://doi.org/10.1016/j.neuro.2018.08.005 [details]
    • Motta-Teixeira, L. C., Machado-Nils, A. V., Battagello, D. S., Diniz, G. B., Andrade-Silva, J., Silva Jr., S., ... Cipolla-Neto, J. (2018). The absence of maternal pineal melatonin rhythm during pregnancy and lactation impairs offspring physical growth, neurodevelopment, and behavior. Hormones and Behavior, 105, 146-156. https://doi.org/10.1016/j.yhbeh.2018.08.006 [details]
    • Schrantee, A., Lucassen, P. J., Booij, J., & Reneman, L. (2018). Serotonin transporter occupancy by the SSRI citalopram predicts default-mode network connectivity. European Neuropsychopharmacology, 28(10), 1173-1179. https://doi.org/10.1016/j.euroneuro.2018.07.099 [details]
    • Zhao, J., Verwer, R. W. H., Gao, S-F., Qi, X-R., Lucassen, P. J., Kessels, H. W., & Swaab, D. F. (2018). Prefrontal alterations in GABAergic and glutamatergic gene expression in relation to depression and suicide. Journal of Psychiatric Research, 102, 261-274. https://doi.org/10.1016/j.jpsychires.2018.04.020 [details]
    • van Campen, J. S., Hessel, E. V. S., Bohmbach, K., Rizzi, G., Lucassen, P. J., Lakshmi Turimella, S., ... Joëls, M. (2018). Stress and Corticosteroids Aggravate Morphological Changes in the Dentate Gyrus after Early-Life Experimental Febrile Seizures in Mice. Frontiers in Endocrinology, 9, [3]. https://doi.org/10.3389/fendo.2018.00003 [details]

    2017

    • Abbink, M. R., Naninck, E. F. G., Lucassen, P. J., & Korosi, A. (2017). Early-life stress diminishes the increase in neurogenesis after exercise in adult female mice. Hippocampus, 27(8), 839-844. https://doi.org/10.1002/hipo.22745 [details]
    • Bielefeld, P., Schouten, M., Lucassen, P. J., & Fitzsimons, C. P. (2017). Transcription factor oscillations in neural stem cells: implications for accurate control of gene expression. Neurogenesis, 4(1), [e1262934]. https://doi.org/10.1080/23262133.2016.1262934 [details]
    • Hoeijmakers, L., Ruigrok, S. R., Amelianchik, A., Ivan, D., van Dam, A-M., Lucassen, P. J., & Korosi, A. (2017). Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer's disease mouse model. Brain, behavior, and immunity, 63, 160-175. https://doi.org/10.1016/j.bbi.2016.12.023 [details]
    • Krugers, H. J., Arp, J. M., Xiong, H., Kanatsou, S., Lesuis, S. L., Korosi, A., ... Lucassen, P. J. (2017). Early life adversity: Lasting consequences for emotional learning. Neurobiology of Stress, 6, 14-21. https://doi.org/10.1016/j.ynstr.2016.11.005 [details]
    • Lesuis, S. L., van Hoek, B. A. C. E., Lucassen, P. J., & Krugers, H. J. (2017). Early postnatal handling reduces hippocampal amyloid plaque formation and enhances cognitive performance in APPswe/PS1dE9 mice at middle age. Neurobiology of Learning and Memory, 144, 27-35. https://doi.org/10.1016/j.nlm.2017.05.016 [details]
    • Loi, M., Mossink, J. C. L., Meerhoff, G. F., Den Blaauwen, J. L., Lucassen, P. J., & Joëls, M. (2017). Effects of early-life stress on cognitive function and hippocampal structure in female rodents. Neuroscience, 342, 101-119. https://doi.org/10.1016/j.neuroscience.2015.08.024 [details]
    • Lucassen, P. J., Korosi, A., Krugers, H. J., & Oomen, C. A. (2017). Early life stress- and sex-dependent effects on hippocampal neurogenesis. In G. Fink (Ed.), Stress: Neuroendocrinology and Neurobiology [135–146] (Handbook of Stress; Vol. 2). Amsterdam: Academic Press. https://doi.org/10.1016/B978-0-12-802175-0.00013-9 [details]
    • Naninck, E. F. G., Oosterink, J. E., Yam, K-Y., de Vries, L. P., Schierbeek, H., van Goudoever, J. B., ... Korosi, A. (2017). Early micronutrient supplementation protects against early stress-induced cognitive impairments. The FASEB Journal, 31(2), 505-518. https://doi.org/10.1096/fj.201600834R [details]
    • Schrantee, A., Tremoleda, J. L., Wylezinska-Arridge, M., Bouet, V., Hesseling, P., Meerhoff, G. F., ... Reneman, L. (2017). Repeated dexamphetamine treatment alters the dopaminergic system and increases the phMRI response to methylphenidate. PLoS ONE, 12(2), [e0172776]. https://doi.org/10.1371/journal.pone.0172776 [details]
    • Solleveld, M. M., Schrantee, A., Puts, N. A. J., Reneman, L., & Lucassen, P. J. (2017). Age-dependent, lasting effects of methylphenidate on the GABAergic system of ADHD patients. NeuroImage: Clinical, 15, 812-818. https://doi.org/10.1016/j.nicl.2017.06.003 [details]
    • Walker, C-D., Bath, K. G., Joels, M., Korosi, A., Larauche, M., Lucassen, P. J., ... Baram, T. Z. (2017). Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential. Stress - the International Journal on the Biology of Stress, 20(5), 421-448. https://doi.org/10.1080/10253890.2017.1343296 [details]
    • Yam, K. Y., Naninck, E. F. G., Abbink, M. R., la Fleur, S. E., Schipper, L., van den Beukel, J. C., ... Korosi, A. (2017). Exposure to chronic early-life stress lastingly alters the adipose tissue, the leptin system and changes the vulnerability to western-style diet later in life in mice. Psychoneuroendocrinology, 77, 186-195. https://doi.org/10.1016/j.psyneuen.2016.12.012 [details]
    • Yam, K. Y., Ruigrok, S. R., Ziko, I., De Luca, S. N., Lucassen, P. J., Spencer, S. J., & Korosi, A. (2017). Ghrelin and hypothalamic NPY/AgRP expression in mice are affected by chronic early-life stress exposure in a sex-specific manner. Psychoneuroendocrinology, 86, 73-77. https://doi.org/10.1016/j.psyneuen.2017.09.006 [details]

    2016

    • Fitzsimons, C. P., Herbert, J., Schouten, M., Meijer, O. C., Lucassen, P. J., & Lightman, S. (2016). Circadian and ultradian glucocorticoid rhythmicity: Implications for the effects of glucocorticoids on neural stem cells and adult hippocampal neurogenesis. Frontiers in Neuroendocrinology, 41, 44-58. https://doi.org/10.1210/en.2012-1484 [details]
    • Herbert, J., & Lucassen, P. J. (2016). Depression as a risk factor for Alzheimer's disease: Genes, steroids, cytokines and neurogenesis - what do we need to know? Frontiers in Neuroendocrinology, 41, 153-171. https://doi.org/10.1016/j.yfrne.2015.12.001 [details]
    • Hoeijmakers, L., Heinen, Y., van Dam, A-M., Lucassen, P. J., & Korosi, A. (2016). Microglial priming and Alzheimer’s disease: a possible role for (early) immune challenges and epigenetics? Frontiers in Human Neuroscience, 10, [398]. https://doi.org/10.3389/fnhum.2016.00398 [details]
    • Hu, P., Wang, Y., Liu, J., Meng, F. T., Qi, X. R., Chen, L., ... Zhou, J. N. (2016). Chronic retinoic acid treatment suppresses adult hippocampal neurogenesis, in close correlation with depressive-like behavior. Hippocampus, 26(7), 911-923. https://doi.org/10.1002/hipo.22574 [details]
    • Kandola, A., Hendrikse, J., Lucassen, P. J., & Yücel, M. (2016). Aerobic exercise as a tool to improve hippocampal plasticity and function in humans: practical implications for mental health treatment. Frontiers in Human Neuroscience, 10, [373]. https://doi.org/10.3389/fnhum.2016.00373 [details]
    • Lesuis, S. L., Maurin, H., Borghgraef, P., Lucassen, P. J., Van Leuven, F., & Krugers, H. J. (2016). Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer’s disease. Oncotarget, 7(26), 39118-39135. https://doi.org/10.18632/oncotarget.9776 [details]
    • Lucassen, P. J., & Oomen, C. A. (2016). Stress, hippocampal neurogenesis and cognition: functional correlations. Frontiers in Biology, 11(3), 182-192. https://doi.org/10.1007/s11515-016-1412-4 [details]
    • Lucassen, P. J., Oomen, C. A., Naninck, E. F. G., Fitzsimons, C. P., van Dam, A-M., Czeh, B., & Korosi, A. (2016). Regulation of adult neurogenesis and plasticity by (early) stress, glucocorticoids and inflammation. In F. H. Gage, G. Kempermann, & H. Song (Eds.), Neurogenesis: a subject collection from Cold Spring Harbor Perspectives in Biology (pp. 255-270). (Cold Spring Harbor perspectives in biology). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/cshperspect.a021303 [details]
    • Lucassen, P. J., Oomen, C. A., Schouten, M., Encinas, J. M., & Fitzsimons, C. P. (2016). Adult Neurogenesis, Chronic Stress and Depression. In J. J. Canales (Ed.), Adult neurogenesis in the hippocampus: health, psychopathology, and brain disease (pp. 177-206). London: Academic Press. https://doi.org/10.1016/B978-0-12-801977-1.00008-8 [details]
    • Reemst, K., Noctor, S. C., Lucassen, P. J., & Hol, E. M. (2016). The Indispensable Roles of Microglia and Astrocytes during Brain Development. Frontiers in Human Neuroscience, 10, [566]. https://doi.org/10.3389/fnhum.2016.00566 [details]
    • Schouten, M., Bielefeld, P., Fratantoni, S. A., Hubens, C. J., Piersma, S. R., Pham, T. V., ... Fitzsimons, C. P. (2016). Multi-omics profile of the mouse dentate gyrus after kainic acid induced status epilepticus. Scientific Data, 3, [160068]. https://doi.org/10.1038/sdata.2016.68 [details]
    • Schrantee, A., Tamminga, H. G. H., Bouziane, C., Bottelier, M. A., Bron, E. E., Mutsaerts, H-JMM., ... Reneman, L. (2016). Age-Dependent Effects of Methylphenidate on the Human Dopaminergic System in Young vs Adult Patients With Attention-Deficit/Hyperactivity Disorder: A Randomized Clincal Trial. JAMA Psychiatry, 73(9), 955-962. https://doi.org/10.1001/jamapsychiatry.2016.1572 [details]
    • Zhao, J., Verwer, R. W. H., van Wamelen, D. J., Qi, X. R., Gao, S. F., Lucassen, P. J., & Swaab, D. F. (2016). Prefrontal changes in the glutamate-glutamine cycle and neuronal/glial glutamate transporters in depression with and without suicide. Journal of Psychiatric Research, 82, 8-15. https://doi.org/10.1016/j.jpsychires.2016.06.017 [details]

    2015

    2014

    • Bielefeld, P., van Vliet, E. A., Gorter, J. A., Lucassen, P. J., & Fitzsimons, C. P. (2014). Different subsets of newborn granule cells: a possible role in epileptogenesis? European Journal of Neuroscience, 39(1), 1-11. https://doi.org/10.1111/ejn.12387 [details]
    • Boekhoorn, K., van Dis, V., Goedknegt, E., Sobel, A., Lucassen, P. J., & Hoogenraad, C. C. (2014). The microtubule destabilizing protein stathmin controls the transition from dividing neuronal precursors to postmitotic neurons during adult hippocampal neurogenesis. Developmental Neurobiology, 74(12), 1226-1242. https://doi.org/10.1002/dneu.22200 [details]
    • Doorn, K. J., Drukarch, B., van Dam, A-M., & Lucassen, P. J. (2014). Hippocampal Proliferation Is Increased in Presymptomatic Parkinson’s Disease and due to Microglia. Neural Plasticity, 2014, 959154. https://doi.org/10.1155/2014/959154 [details]
    • Doorn, K. J., Goudriaan, A., Blits-Huizinga, C., Bol, J. G. J. M., Rozemuller, A. J., Hoogland, P. V. J. M., ... van Dam, A-M. (2014). Increased Amoeboid Microglial Density in the Olfactory Bulb of Parkinson's and Alzheimer's Patients. Brain Pathology, 24(2), 152-165. https://doi.org/10.1111/bpa.12088 [details]
    • Doorn, K. J., Moors, T., Drukarch, B., van de Berg, W. D. J., Lucassen, P. J., & van Dam, A-M. (2014). Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson's disease patients. Acta Neuropathologica Communications, 2, 90. https://doi.org/10.1186/s40478-014-0090-1 [details]
    • Fitzsimons, C. P., van Bodegraven, E., Schouten, M., Lardenoije, R., Kompotis, K., Kenis, G., ... Rutten, B. P. F. (2014). Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease. Molecular Neurodegeneration, 9, 25. https://doi.org/10.1186/1750-1326-9-25 [details]
    • Hoeijmakers, L., Harbich, D., Schmid, B., Lucassen, P. J., Wagner, K. V., Schmidt, M. V., & Hartmann, J. (2014). Depletion of FKBP51 in female mice shapes HPA axis activity. PLoS ONE, 9(4), e95796. https://doi.org/10.1371/journal.pone.0095796 [details]
    • Hoeijmakers, L., Lucassen, P. J., & Korosi, A. (2014). The interplay of early-life stress, nutrition, and immune activation programs adult hippocampal structure and function. Frontiers in Molecular Neuroscience, 7, 103. https://doi.org/10.3389/fnmol.2014.00103 [details]
    • Klomp, A., Václavů, L., Meerhoff, G. F., Reneman, L., & Lucassen, P. J. (2014). Effects of chronic fluoxetine treatment on neurogenesis and tryptophan hydroxylase expression in adolescent and adult rats. PLoS ONE, 9(5), [e97603]. https://doi.org/10.1371/journal.pone.0097603 [details]
    • Loi, M., Koricka, S., Lucassen, P. J., & Joëls, M. (2014). Age- and sex-dependent effects of early life stress on hippocampal neurogenesis. Frontiers in Endocrinology, 5, [13]. https://doi.org/10.3389/fendo.2014.00013 [details]
    • Lucassen, P. J., Pruessner, J., Sousa, N., Almeida, O. F. X., van Dam, A. M., Rajkowska, G., ... Czéh, B. (2014). Neuropathology of stress. Acta Neuropathologica, 127(1), 109-135. https://doi.org/10.1007/s00401-013-1223-5 [details]
    • Marlatt, M. W., Bauer, J., Aronica, E., van Haastert, E. S., Hoozemans, J. J. M., Joels, M., & Lucassen, P. J. (2014). Proliferation in the Alzheimer hippocampus is due to microglia, not astroglia, and occurs at sites of amyloid deposition. Neural Plasticity, 2014, 693851. https://doi.org/10.1155/2014/693851 [details]
    • Wang, Q., Verweij, E. W. E., Krugers, H. J., Joels, M., Swaab, D. F., & Lucassen, P. J. (2014). Distribution of the glucocorticoid receptor in the human amygdala; changes in mood disorder patients. Brain Structure and Function, 219(5), 1615-1626. https://doi.org/10.1007/s00429-013-0589-4 [details]
    • van der Marel, K., Klomp, A., Meerhoff, G. F., Schipper, P., Lucassen, P. J., Homberg, J. R., ... Reneman, L. (2014). Long-Term Oral Methylphenidate Treatment in Adolescent and Adult Rats: Differential Effects on Brain Morphology and Function. Neuropsychopharmacology, 39(2), 263-273. https://doi.org/10.1038/npp.2013.169 [details]

    2013

    2012

    • Claessens, S. E. F., Belanoff, J. K., Kanatsou, S., Lucassen, P. J., Champagne, D. L., & de Kloet, E. R. (2012). Acute effects of neonatal dexamethasone treatment on proliferation and astrocyte immunoreactivity in hippocampus and corpus callosum: Towards a rescue strategy. Brain Research, 1482, 1-12. https://doi.org/10.1016/j.brainres.2012.08.017 [details]
    • Datson, N. A., Speksnijder, N., Mayer, J. L., Steenbergen, P. J., Korobko, O., Goeman, J., ... Lucassen, P. J. (2012). The transcriptional response to chronic stress and glucocorticoid receptor blockade in the hippocampal dentate gyrus. Hippocampus, 22(2), 359-371. https://doi.org/10.1002/hipo.20905 [details]
    • Doorn, K. J., Lucassen, P. J., Boddeke, H. W., Prins, M., Berendse, H. W., Drukarch, B., & van Dam, A. M. (2012). Emerging roles of microglial activation and non-motor symptoms in Parkinson's disease. Progress in Neurobiology, 98(2), 222-238. https://doi.org/10.1016/j.pneurobio.2012.06.005 [details]
    • Fitzsimons, C. P., Vreugdenhil, E., & Lucassen, P. J. (2012). Inhibition of Adult Neurogenesis through ERK5 knockdown Impairs Complex Hippocampus-dependent Spatial Memory Tasks. Future Neurology, 7(5), 531-535. https://doi.org/10.2217/fnl.12.55 [details]
    • Hu, P., Oomen, C., van Dam, A. M., Wester, J., Zhou, J. N., Joëls, M., & Lucassen, P. J. (2012). A single-day treatment with mifepristone is sufficient to normalize chronic glucocorticoid induced suppression of hippocampal cell proliferation. PLoS ONE, 7(9), [e46224]. https://doi.org/10.1371/journal.pone.0046224 [details]
    • Korosi, A., Naninck, E. F. G., Oomen, C. A., Schouten, M., Krugers, H., Fitzsimons, C., & Lucassen, P. J. (2012). Early-life stress mediated modulation of adult neurogenesis and behavior. Behavioural Brain Research, 227(2), 400-409. https://doi.org/10.1016/j.bbr.2011.07.037 [details]
    • Krugers, H. J., Oomen, C. A., Gumbs, M., Li, M., Velzing, E. H., Joëls, M., & Lucassen, P. J. (2012). Maternal deprivation and dendritic complexity in the basolateral amygdala. Neuropharmacology, 62(1), 534-537. https://doi.org/10.1016/j.neuropharm.2011.09.022 [details]
    • Lucassen, P. J. (2012). Chemotherapy modulates specific aspects of cognition parallel to neurogenesis (Commentary on Nokia et al.). European Journal of Neuroscience, 36, 3519-3520. https://doi.org/10.1111/ejn.12056 [details]
    • Marlatt, M. W., Potter, M. C., Lucassen, P. J., & van Praag, H. (2012). Running throughout middle-age improves memory function, hippocampal neurogenesis and BDNF levels in female C57Bl/6J mice. Developmental Neurobiology, 72(6), 943-952. https://doi.org/10.1002/dneu.22009 [details]
    • Saaltink, D. J., Håvik, B., Verissimo, C., Lucassen, P. J., & Vreugdenhil, E. (2012). Doublecortin and doublecortin-like are expressed in overlapping and non-overlapping neuronal cell population: implications for neurogenesis. The journal of comparative neurology, 520(13), 2805-2823. https://doi.org/10.1002/cne.23144 [details]
    • Schouten, M., Buijink, M. R., Lucassen, P. J., & Fitzsimons, C. P. (2012). New neurons in aging brains: molecular control by small non-coding RNAs. Frontiers in Neuroscience, 6, [25]. https://doi.org/10.3389/2Ffnins.2012.00025 [details]
    • Wang, Q., Joëls, M., Swaab, D. F., & Lucassen, P. J. (2012). Hippocampal GR expression is increased in elderly depressed females. Neuropharmacology, 62(1), 527-533. https://doi.org/10.1016/j.neuropharm.2011.09.014 [details]

    2011

    • Bruel-Jungerman, E., Lucassen, P. J., & Francis, F. (2011). Cholinergic influences on cortical development and adult neurogenesis. Behavioural Brain Research, 221(2), 379-388. https://doi.org/10.1016/j.bbr.2011.01.021 [details]
    • Eendebak, R. J. A. H., Lucassen, P. J., & Fitzsimons, C. P. (2011). Nuclear receptors and microRNAs: who regulates the regulators in neural stem cells? FEBS Letters, 585(5), 717-22. https://doi.org/10.1016/j.febslet.2011.01.039 [details]
    • Lemmens, M. A. M., Sierksma, A. S. R., Rutten, B. P. F., Dennissen, F., Steinbusch, H. W. M., Lucassen, P. J., & Schmitz, C. (2011). Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer's disease. Brain Structure and Function, 216(3), 227-237. https://doi.org/10.1007/s00429-011-0305-1 [details]
    • Lucassen, P. J., Fitzsimons, C. P., Vreugdenhil, E., Hu, P., Oomen, C., Revsin, Y., ... de Kloet, E. R. (2011). Regulation of structural plasticity and neurogenesis during stress and diabetes; protective effects of glucocorticoid receptor antagonists. In A. G. Gravanis, & S. H. Mellon (Eds.), Hormones in neurodegeneration, neuroprotection, and neurogenesis (pp. 103-120). Weinheim: Wiley-VCH. https://doi.org/10.1002/9783527633968.ch6 [details]
    • Marlatt, M. W., Philippens, I., Manders, E., Czeh, B., Joëls, M., Krugers, H., & Lucassen, P. J. (2011). Distinct structural plasticity in the hippocampus and amygdala of the middle-aged common marmoset (Callithrix jacchus). Experimental Neurology, 230(2), 291-301. https://doi.org/10.1016/j.expneurol.2011.05.008 [details]
    • Naninck, E. F. G., Lucassen, P. J., & Bakker, J. (2011). Sex differences in adolescent depression: do sex hormones determine vulnerability? Journal of Neuroendocrinology, 23(5), 383-392. https://doi.org/10.1111/j.1365-2826.2011.02125.x [details]
    • Novati, A., Hulshof, H. J., Koolhaas, J. M., Lucassen, P. J., & Meerlo, P. (2011). Chronic sleep restriction causes a decrease in hippocampal volume in adolescent rats, which is not explained by changes in glucocorticoid levels or neurogenesis. Neuroscience, 190, 145-155. https://doi.org/10.1016/j.neuroscience.2011.06.027 [details]
    • Oomen, C. A., Soeters, H., Audureau, N., Vermunt, L., van Hasselt, F. N., Manders, E. M. M., ... Lucassen, P. J. (2011). Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female rats. Psychopharmacology, 214(1), 249-260. https://doi.org/10.1007/s00213-010-1922-8 [details]
    • Van Bokhoven, P., Oomen, C. A., Hoogendijk, W. J., Smit, A. B., Lucassen, P. J., & Spijker, S. (2011). Reduction in hippocampal neurogenesis after social defeat is long-lasting and responsive to late antidepressant treatment. European Journal of Neuroscience, 33(10), 1833-1840. https://doi.org/10.1111/j.1460-9568.2011.07668.x [details]
    • Xiao, A. W., He, J., Wang, Q., Luo, Y., Sun, Y., Zhou, Y. P., ... Dai, J. P. (2011). The origin and development of plaques and phosphorylated tau are associated with axonopathy in Alzheimer's disease. Neuroscience bulletin, 27(5), 287-99. https://doi.org/10.1007/s12264-011-1736-7 [details]
    • van Tijn, P., Kamphuis, W., Marlatt, M. W., Hol, E. M., & Lucassen, P. J. (2011). Presenilin mouse and zebrafish models for dementia: Focus on neurogenesis. Progress in Neurobiology, 93(2), 149-164. https://doi.org/10.1016/j.pneurobio.2010.10.008 [details]

    2010

    • Christensen, D. Z., Schneider-Axmann, T., Lucassen, P. J., Bayer, T. A., & Wirths, O. (2010). Accumulation of intraneuronal Aβ correlates with ApoE4 genotype. Acta Neuropathologica, 119(5), 555-566. https://doi.org/10.1007/s00401-010-0666-1 [details]
    • Krugers, H. J., Lucassen, P. J., Karst, H., & Joëls, M. (2010). Chronic stress effects on hippocampal structure and synaptic function: relevance for depression and normalization by anti-glucocorticoid treatment. Frontiers in Synaptic Neuroscience, 2(24), 24. https://doi.org/10.3389/fnsyn.2010.00024 [details]
    • Lucassen, P. J., Meerlo, P., Naylor, A. S., van Dam, A. M., Dayer, A. G., Fuchs, E., ... Czéh, B. (2010). Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action. European Neuropsychopharmacology, 20(1), 1-17. https://doi.org/10.1016/j.euroneuro.2009.08.003 [details]
    • Lucassen, P. J., Stumpel, M. W., Wang, Q., & Aronica, E. (2010). Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients. Neuropharmacology, 58(6), 940-949. https://doi.org/10.1016/j.neuropharm.2010.01.012 [details]
    • Marlatt, M. W., & Lucassen, P. J. (2010). Neurogenesis and Alzheimer's disease: biology and pathophysiology in mice and men. Current Alzheimer Research, 7(2), 113-125. https://doi.org/10.2174/156720510790691362 [details]
    • Marlatt, M. W., Lucassen, P. J., & van Praag, H. (2010). Comparison of neurogenic effects of fluoxetine, duloxetine and running in mice. Brain Research, 1341, 93-99. https://doi.org/10.1016/j.brainres.2010.03.086 [details]
    • Oomen, C. A., Soeters, H., Audureau, N., Vermunt, L., van Hasselt, F. N., Manders, E. M. M., ... Krugers, H. (2010). Severe early life stress hampers spatial learning and neurogenesis, but improves hippocampal synaptic plasticity and emotional learning under high-stress conditions in adulthood. The Journal of Neuroscience, 30(19), 6635-6645. https://doi.org/10.1523/JNEUROSCI.0247-10.2010 [details]
    • Wirths, O., Bethge, T., Marcello, A., Harmeier, A., Jawhar, S., Lucassen, P. J., ... Bayer, T. A. (2010). Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases. Journal of Neural Transmission, 117(1), 85-96. https://doi.org/10.1007/s00702-009-0314-x [details]

    2009

    • Bao, A. M., Lucassen, P. J., & Swaab, D. F. (2009). Neuroendocrinology of psychiatric disorders. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 2641-2645). Berlin: Springer. [details]
    • Boekhoorn, K., & Lucassen, P. J. (2009). Nieuwe neuronen in volwassen hersenen. Tijdschrift voor Neuropsychiatrie & Gedragsneurologie, (juni), 119-123. [details]
    • Boer, K., Lucassen, P. J., Spliet, W. G. M., Vreugdenhil, E., van Rijen, P. C., Troost, D., ... Aronica, E. (2009). Doublecortin-like (DCL) expression in focal cortical dysplasia and cortical tubers. Epilepsia, 50(12), 2629-2637. https://doi.org/10.1111/j.1528-1167.2009.02191.x [details]
    • Joosen, M. J. A., Jousma, E., van den Boom, T. M., Kuijpers, W. C., Smit, A. B., Lucassen, P. J., & van Helden, H. P. M. (2009). Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning. Neurotoxicology, 30(1), 72-80. https://doi.org/10.1016/j.neuro.2008.11.010 [details]
    • Joëls, M., Krugers, H. J., Lucassen, P. J., & Karst, H. (2009). Corticosteroid effects on cellular physiology of limbic cells. Brain Research, 1293, 91-100. https://doi.org/10.1016/j.brainres.2009.03.036 [details]
    • Lucassen, P. J., & Swaab, D. F. (2009). Endocrine disorders of development and growth. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 1103-1106). Berlin: Springer. [details]
    • Lucassen, P. J., & Swaab, D. F. (2009). Hypothalamo-pituitary-adrenal axis, stress and depression. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 1892-1895). Berlin: Springer. [details]
    • Lucassen, P. J., Boekhoorn, K., & Francis, F. (2009). Cortical development - Disorders. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 894-896). Berlin: Springer. [details]
    • Lucassen, P. J., Bosch, O. J., Jousma, E., Krömer, S. A., Andrew, R., Seckl, J. R., & Neumann, I. D. (2009). Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: Possible key role of placental 11β-hydroxysteroid dehydrogenase type 2. European Journal of Neuroscience, 29(1), 97-103. https://doi.org/10.1111/j.1460-9568.2008.06543.x [details]
    • Lucassen, P. J., Meerlo, P., Naylor, A. S., van Dam, A. M., Dayer, A. G., Czeh, B., & Oomen, C. A. (2009). Do depression, stress, sleep disruption, and inflammation alter hippocampal apoptosis and neurogenesis? In C. M. Pariante (Ed.), Understanding depression: A translational approach (pp. 139-156). Oxford: Oxford University Press. [details]
    • Lucassen, P. J., Scheper, W., & van Someren, E. J. W. (2009). Adult neurogenesis and the unfolded protein response; new cellular and molecular avenues in sleep research. Sleep Medicine Reviews, 13(3), 183-186. https://doi.org/10.1016/j.smrv.2008.12.004 [details]
    • Marlatt, M. W., Hoozemans, J. J. M., Veerhuis, R., & Lucassen, P. J. (2009). Alzheimer’s disease and adult neurogenesis—Are endogenous stem cells part of the solution? US Neurology, 5(1), 12-14. [details]
    • Oomen, C. A., Girardi, C. E. N., Cahyadi, R., Verbeek, E. C., Krugers, H., Joëls, M., & Lucassen, P. J. (2009). Opposite effects of early maternal deprivation on neurogenesis in male versus female rats. PLoS ONE, 4(1), e3675. https://doi.org/10.1371/journal.pone.0003675 [details]
    • Swaab, D. F., & Lucassen, P. J. (2009). Drinking disorders and osmoregulation. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 1010-1014). Berlin: Springer. [details]
    • Swaab, D. F., & Lucassen, P. J. (2009). Hypothalamo-neurohypophysial system. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 1888-1892). Berlin: Springer. [details]
    • Swaab, D. F., & Lucassen, P. J. (2009). Neuroendocrinology of eating disorders. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 2635-2637). Berlin: Springer. [details]
    • Swaab, D. F., & Lucassen, P. J. (2009). Neuroendocrinology of tumors. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 2645-2648). Berlin: Springer. [details]
    • Swaab, D. F., & Lucassen, P. J. (2009). Neuroendocrinology. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 2631-2635). Berlin: Springer. [details]

    2008

    • Boekhoorn, K., Sarabdjitsingh, A., Kommerie, H., de Punder, K., Schouten, T., Lucassen, P. J., & Vreugdenhil, E. (2008). Doublecortin (DCX) and doublecortin-like (DCL) are differentially expressed in the early but not late stages of murine neocortical development. The journal of comparative neurology, 507(4), 1639-1652. https://doi.org/10.1002/cne.21646 [details]
    • Lucassen, P. J., Oomen, C., van Dam, A-M., & Czéh, B. (2008). Regulation of hippocampal neurogenesis by systemic factors including stress, glucocorticoids, sleep, and inflammation. In F. H. Gage, G. Kempermann, & H. Song (Eds.), Adult neurogenesis (pp. 363-396). (Cold Spring Harbor monograph series; Vol. 52). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. [details]
    • Marlatt, M. W., Lucassen, P. J., Perry, G., Smith, M. A., & Zhu, X. (2008). Alzheimer's disease: Cerebrovascular dysfunction, oxidative stress, and advanced clinical therapies. Journal of Alzheimer's Disease, 15(2), 199-210. [details]
    • Simic, G., Mladinov, M., Seso Simic, D., Jovanov Milosevic, N., Islam, A., Pajtak, A., ... Kruslin, B. (2008). Abnormal motoneuron migration, differentiation, and axon outgrowth in spinal muscular atrophy. Acta Neuropathologica, 115(3), 313-326. https://doi.org/10.1007/s00401-007-0327-1 [details]
    • Thompson, A., Boekhoorn, K., van Dam, A-M., & Lucassen, P. J. (2008). Changes in adult neurogenesis in neurodegenerative diseases: Cause or consequence? Genes Brain and Behavior, 7(s1), 28-42. https://doi.org/10.1111/j.1601-183X.2007.00379.x [details]

    2015

    • Kanatsou, S., Fearey, B. C., Kuil, L. E., Lucassen, P. J., Harris, A. P., Seckl, J. R., ... Joels, M. (2015). Correction: Overexpression of Mineralocorticoid Receptors Partially Prevents Chronic Stress-Induced Reductions in Hippocampal Memory and Structural Plasticity. PLoS ONE, 10(12), [e0145706]. https://doi.org/10.1371/journal.pone.0145706

    2014

    • Kuipers, S. D., Bramham, C. R., Cameron, H. A., Fitzsimons, C. P., Korosi, A., & Lucassen, P. J. (2014). Environmental Control of Adult Neurogenesis: From Hippocampal Homeostasis to Behavior and Disease. Neural Plasticity, 2014, 808643. https://doi.org/10.1155/2014/808643 [details]

    2015

    2008

    • Lucassen, P. J., Verbeek, E. C., & Oomen, C. A. (2008). Wat doen die nieuwe hersencellen daar? Neurogenese en celdood in volwassen hersenen. BLIND : Interdisciplinair Tijdschrift, 15. [details]

    Lidmaatschap

    • Lucassen, P. J. (2017). Invited international Faculty Opponent for the PhD thesis of C Von Lindow, promotor; Prof.dr. B. Finsen and Prof.Dr. M West, Aarhus University.
    • Lucassen, P. J. (2016-). Fellow and Programme committee member ECNP, ECNP.
    • Lucassen, P. J. (2016-). Review panel member for Research Council Norway ., Research Council Norway.
    • Lucassen, P. J. (2016-). Review panel member for Donders Institute, Donders Institute.
    • Lucassen, P. J. (2016-). Review panel member for ABC, Amsterdam Brain and Cognition UvA.
    • Lucassen, P. J. (2016-). Review panel member for ANR, ANR.
    • Lucassen, P. J. (2016-). Review panel member for SFI, SFI.
    • Lucassen, P. J. (2016-2017). Chairman of the Scientific Advisory Board of the Campagneteam Huntington, Huntington.
    • Lucassen, P. J. (2016-2017). Chairman of the Scientific Advisory Board, Alzheimer Nederland.

    Tijdschriftredactie

    • Lucassen, P. J. (editor) (2016-2017). Stress - the International Journal on the Biology of Stress (Journal).
    • Lucassen, P. J. (editor) (2016-2017). PLoS ONE (Journal).
    • Lucassen, P. J. (editor) (2016-2017). Neuroscience (Journal).
    • Lucassen, P. J. (editor) (2016-). Brain Plasticity (Journal).

    Spreker

    • Lucassen, P. J. (speaker) (25-10-2017). Stem cells, hippocampal neurogenesis, stress and depression., Department of Psychiatry Athens.
    • Lucassen, P. J. (speaker) (2-12-2016). Neurogenesis and Alzheimer, Neurodegeneration symposium, Maastricht, Netherlands.

    Andere

    • Lucassen, P. J. (participant) (10-2018). 31st ECNP Congress - Barcelona 2018, Barcelona, Spain. sessions organized and chaired by Paul Lucassen on 'New advances in the therapy of Huntington’s and Parkinson’s disease’. (participating in a conference, workshop, ...).
    • Lucassen, P. J. (other) (1-1-2016). a novel Erasmus training program with University Athens (other).

    2017

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