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dhr. prof. dr. P.J. (Paul) Lucassen

Faculteit der Natuurwetenschappen, Wiskunde en Informatica
Swammerdam Institute for Life Sciences
Fotograaf: Paul Lucassen

  • Lucassen group; "Plasticity of the Brain".
    Newborn neurons (white) in the adult rodent hippocampus (blue), image courtesy Dr B. Czeh.

    General information; research topics

    Our main interest is structural plasticity in relation to stress and disease. In addition to apoptosis, we focus on the regulation of adult neurogenesis and its relevance for cognition, depression and dementia. Neurogenesis is prominent particularly during early development, and our primary focus is effects of early stress on (development of) the hippocampus. This brain structure is very sensitive to stress hormone action, implicated in learning and memory and affected in both these disease conditions. The hippocampus is furthermore unique as it contains stem cells that continue to generate new neurons in adult animals, including humans, a process called "adult neurogenesis".
    Key interest is the functional relevance of adult neurogenesis for brain function. We are interested in whether blockade or normalization of stress effects on neurogenesis in adult life can be beneficial in terms of e.g. recovery from depression. We hypothesize that e.g. stress-inducedreductions in the number of newborn neurons is deterined during early development and will interfere with the role of the hippocampus e.g. in cognition and in negative feedback of the HPA-axis in adult life. We further study how such deficits can be influenced and possibly ameliorated by means of early diet, antidepressant treatment, or physical or cognitively challenging events such as life long learning and exercise.

    Personal websites:

    http://sils.uva.nl/sfpns

    Verwijzing

    Selected recent key publications;

    - PJ Lucassen, CP Fitzsimons, A Korosi, M Joels, C Belzung and DN Abrous. Stressing new neurons into depression? Mol Psychiatry 2013 18: 396-397.

    - C P Fitzsimons, L W A van Hooijdonk, M Schouten, I Zalachoras, V Brinks, T Zheng, T G Schouten, D J Saaltink, T Dijkmans, D A Steindler, J Verhaagen, F J Verbeek, P J Lucassen, E R de Kloet, O C Meijer, H Karst, M Joels, M S Oitzl and E Vreugdenhil. Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior. Mol Psychiatry 2013 18: 993-1005.

    - I Zalachoras, R Houtman, E Atucha, R Devos, AMI Tijssen, P Hu, P Lockey, NA Datson, J Belanoff , PJ Lucassen, M Joëls, ER de Kloet, B Roozendaal, H Hunt, OC Meijer. Differential Targeting of Brain Stress Circuits with a Selective Glucorticoid Receptor Modulator. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7910-5.

    - Paul J. Lucassen, Eva F.G. Naninck, Johannes B. van Goudoever, Carlos Fitzsimons, Marian Joels and Aniko Korosi. Perinatal programming of hippocampal structure and function; emerging roles of stress, neurogenesis, epigenetics and early nutrition. Trends in Neuroscience, 2013.

    - PJ Lucassen, N Sousa, OFX Almeida, G Rajkowska, J Pruessner, DF Swaab and B Czeh. Neuropathology of Stress. Acta Neuropathologica, 2014.

    - A. Schrantee, G.H. Tamminga, C. Bouziane, M.A. Bottelier, E.E. Bron, H.J.M. Mutsaerts, K. Zwinderman, I.R. Groote, S.A.R.B. Rombouts, R.J.L. Lindauer, W. Niessen, S. Klein, B.C. Opmeer, F. Boer, P.J. Lucassen, S.L. Andersen, H.M. Geurts and L. Reneman. A randomized trial on the age-dependency of methylphenidate effects on the human dopamine system. JAMA Psychiatry, 2016; 73(9):955-62.

    - SL Lesuis, H Maurin, P Borghgraef, PJ Lucassen, F Van Leuven, HJ Krugers. Positive and negative early life experiences differentially modulate longterm survival and amyloid protein levels in a mouse model of Alzheimer’s disease. Oncotarget. 2016 Jun 1. doi: 10.18632/oncotarget.9776.

    - E.F.G. Naninck, J.E. Oosterink, K.Y.Yam, L. de Vries, H. Schierbeek, J.B. van Goudoever, R.N. Verkaik-Schakel, J.A. Plantinga, T. Plosch, P.J. Lucassen and A. Korosi. Early micronutrient supplementation protects against early stress induced cognitive impairments. The FASEB Journal, 2017 Feb;31(2):505-518, DOI 10.1096/fj.201600834R.

    - Yam KY, E.F.G. Naninck, M.R. Abbink, S.E. la Fleur, L. Schipper, J.C. van den Beukel, A. Grefhorst, A. Oosting, E.M. van der Beek, P.J. Lucassen, A. Korosi. Exposure to chronic early-life stress lastingly alters the adipose tissue, the leptin system and changes the vulnerability to western-style diet later in life in mice. Psychoneuroendocrinology 77 (2017) 186–195.

    - SL Lesuis, S Weggen, S Baches, PJ Lucassen, HJ Krugers. Early life stress accelerates amyloid pathology and cognitive decline in an Alzheimer mouse model, which can be rescued by briefly blocking glucocorticoid receptors at middle age. Transl. Psych. 2018.

    - Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, Kuhn HG, Jessberger S, Frankland PW, Cameron HA, Gould E, Hen R, Abrous DN, Toni N, Schinder AF, Zhao X, Lucassen PJ, Frisén J. Human Adult Neurogenesis: Evidence and Remaining Questions. Cell Stem Cell. 2018. 

    - SL Lesuis, Hoeijmakers L, Korosi A, de Rooij SR, Swaab DF, Kessels HW, Lucassen PJ*, Krugers HJ*. Vulnerability and resilience to Alzheimer's disease: early life conditions modulate neuropathology and determine cognitive reserve. Alzheimers Res Ther. 2018.

    - KY Yam, L Schipper, K Reemst, SR Ruigrok, MR Abbink, L Hoeijmakers, EFG Naninck, P Zarekiani, A Oosting, EM Van der Beek, PJ Lucassen, A Korosi. Increasing availability of omega-3 fatty acid in the early life diet prevents the early-life stress induced cognitive impairments without affecting metabolic alterations. The FASEB Journal 2019.

    - PJ Lucassen, N Toni, G Kempermann, J Frisen, FH Gage and DF Swaab. Limits to human neurogenesis - really?  Mol.Psych. 2019.

    - J Zhao, PJ Lucassen, DF Swaab. 2019. Suicide is a confounder in postmortem studies on depression. Biol. Psych. 2019.

    - Schouten M*, Bielefeld P*, Passchier EMJ, Garcia-Corzo L, Gradari S, Jungenitz T, Pons-Espinal M, Gebara E, Martín-Suárez S, Lucassen PJ, de Vries HE, Schwarzacher SW, De Pietri Tonelli D, Toni N, Trejo JL, Mira H, Encinas JM and Fitzsimons CP. Circadian Glucocorticoid Oscillations Preserve a Population of Adult Hippocampal Neural Stem Cells in the Aging Brain. Mol. Psych. 2019.

     

    Video link to Paul Lucassen on Adult Neurogenesis (YouTube);

    http://www.youtube.com/watch?v=RI92wpnSkUU

     

    Paul Lucassen on Stem Cells and Neurogenesis

    Publications of PJ Lucassen on PubMed

  • Recent lectures, outreach, etc

    Lectures delivered;

    2015;
    1.    Invited Lecture "Structural plasticity in relation to (early) stress, nutrition and depression." Host; Dr. S. Schwarzacher, Dept Klinische NeuroAnatomie, Goethe Universitat, Frankfurt am Main, Germany, 15 Jan 2015.
    2.    Lecture; 'Trends in Alzheimer's disease research, a personal perspective' at the ISAO Meet and Greet meeting, Jaarbeurs Utrecht, 28 Jan 2015.
    3.    Invited Lecture "Effects of early life stress and nutrition on adult hippocampal plasticity and function" at MRC Social, Genetic and Developmental Psychiatry Centre (host; Dr Geoff Bird), Institute of Psychiatry, King's College London, United Kingdom, 16 Feb 2015.
    4.    Lecture 'Plasticity in relation to stress and neurogenesis'. Host; Dr Sandrine Thuret, King's College London, United Kingdom, Febr 17th 2015.
    5.    Invited Lecture 'Structural plasticity in relation to (early) stress, depression and dementia', at the Department of Fundamental Neurosciences, University of Lausanne  (host; Dr. N. Toni), Lausanne, Switzerland, 4th march 2015.
    6.    Invited lecture 'Hippocampal plasticity in relation to early stress, nutrition and depression', at the Department of Anatomy, ETH (hosts; Dr I Amrein, M Van Dijk), Zurich, Switzerland, 4th March 2015.
    7.    Invited Lecture "Structural plasticity in relation to (early) stress and depression", at the session on "Structural dynamics of adult neurogenesis" at the 17th International Neuroscience Winter Conference (host; Dr. S. Schwarzarcher), Solden, Switzerland, 10 April 2015.
    8.    Lecture "Structural plasticity, (early) stress, antidepressants and major depression", at the minisymposium on the occasion of the visit of Dr Snezana Milanovic at the AMC, Amsterdam, 28 may 2015.
    9.    Invited Lecture 'Application of MRS as tool to measure adult neurogenesis in the live human brain', ABC conference, Theater De Brakke Grond, Amsterdam, 1 Juni 2015.
    10.    Invited lecture 'Science matters; stress & stem cells', at the Biomedical Symposium Radboud Universiteit Nijmegen, 1 juli 2015. 
    11.    Invited lecture "Hippocampal plasticity in relation to (early) stress, nutrition and depression', at the Adult Neurogenesis meeting, Provence, France, 17 Sept 2015.
    12.    ECNP supported, plenary lecture at the 8th Simposium Psiquiatria de Braga; 'Structural plasticity in relation to early stress, nutrition and depression' at the University of Minho, Braga, Portugal, Oct 1st 2015.
    13.    Invited lecture’ ‘'Hippocampal plasticity in relation to early stress, nutrition and depression’ at the symposium on PTSD in Bristol, UK, hosts; Prof.Dr. Hans Reul, Prof.Dr. Astrid Linthorst, 16/17 November 2015.
    14.    Invited Plenary Lecture "Nieuwe cellen in het volwassen brein; stamcellen en sport" (laymen talk in Dutch) at the Opening Symposium of the "Exercise and the brain" week (supported by the Cruyff foundation) at the Amstelveen College, Amstelveen The Netherlands, 15 Dec 2015.

     

    2016;
    15.    Invited lecture 'Plasticity changes in relation to (early) stress, depression and dementia, at the Danish Academy, Aarhus University, Aarhus, Denmark, 14 jan 2016. 
    16.    Invited lecture 'Hippocampal plasticity in relation to early stress, nutrition and depression", at the 2016 IBRO Workshop, organized by the Hungarian Academy of Sciences, opening lecture of the symposium “Behavioral, Endocrine and Neuropathological Consequences of Stressful Life Events”. Budapest, Hungary, January 22nd, 2016. 
    17.    Invited Plenary lecture 'Ins and outs of Adult Neurogenesis', at the 5th Biennial ICCTF Meeting, Netherlands Cancer Institute Amsterdam, 15th March 2016 (host; Dr. S. Schagen).
    18.    Invited participant/discussant for the Round Table Expert meeting on Early Life Stress, at the 'Neurobiology of Stress' conference, 12-14 april in Newport Beach, Irvine, USA (host; Prof.Dr. T. Baram).
    19.    Invited lecture 'Structural plasticity and neurogenesis in relation to (early) stress, depression and dementia', Department of Neuroscience, Universitat de Valencia, Valencia, Spain, April 25th 2016 (host; Dr. J. Nacher). 
    20.    Invited Plenary Lecture "New neurons in adult brains; an emerging substrate for brain plasticity programmed during early life", at the Spring conference on 'Neuroplasticity & Cognitive Reserve' of the Dutch Association for NeuroPsychology, 13 may 2016, (host; Prof.Dr. B. Schmand), Muntgebouw Utrecht, the Netherlands.
    21.    Invited 'University of Amsterdam' lecture (in Dutch); 'Nieuwe zenuwcellen voor het volwassen brein', at the Universiteitsdag, Oudemanhuispoort, June 4th 2016, Amsterdam.
    22.    Invited talk 'Early stress and neurogenesis; the importance of nutritional programming for later cognition', at the 3rd EUROGENESIS meeting, July 12-15th 2016, Bordeaux, France.
    23.    Invited talk "(Early) stress effects on neurogenesis and plasticity", at the meeting of the British Psychiatry Association (BAP), Brighton UK, 17-20 July 2016.
    24.    Invited lecture; "Hippocampal plasticity, (early) stress and depression" at the ISPNE meeting in Miami, USA. 12 Sept 2016.
    25.    Invited Keynote speaker on 'Neurogenesis and Alzheimer", University Maastricht, 2 Dec 2016.


    2017;
    26.    Invited Lecture "Structural hippocampal plasticity and neurogenesis in relation to dementia", at the Alzheimer Center of the VUMC Amsterdam, hosts; PJ Visser, P Scheltens, W van der Flier, 20 Jan 2017.
    27.    Lecture 'An overview of Alzheimer research; the state of the affairs (in Dutch)", at the Netherlands Institute for Brain Research NIN, 7 Feb 2017. 
    28.    Invited Lecture 'Structural plasticity in relation to depression and dementia', at the Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark (host; Prof. Dr. B. Finsen), Odense, Denmark, 9 March 2017. 
    29.    Invited lecture on 'Regulation of neurogenesis by stress and antidepressants' at the Varna meeting on 'Adult primate neurogenesis', Varna, Bulgaria, 20 may 2017.
    30.    Invited Lecture on 'Our brain under stress (in Dutch)', at the Pawlik Congres – 'Presteren onder Druk', georganiseerd door Pawlik Consultants, Dauphine, Amsterdam, 30 may 2017. 
    31.    Moderator/chair/introductory talk of the session on 'Exercise and psychiatric disease; should patients take the challenge?' at the ECNP meeting in Paris, France, Sept 2017.
    32.    Invited Lecture ‘New neurons in, and for, adult brains; environmental regulation and functional roles’, within the framework of an ERASMUS exchange program at the Athens University, 24th October 2017.
    33.    Invited Lecture ‘Stem cells, hippocampal neurogenesis, stress and depression’, at the Dept of Psychiatry, University of Athens (host; Dr M. Panayatocopolou), 25th Oct 2017.
    34.    Invited laymens talk on ‘Our brain under stress’ (in Dutch), for the crowdfunded project on ‘Stress and the heart’, awarded to Dr A. Schrantee’ at the AMC Amsterdam, 31 Oct 2017.

    2018;
    35.    Invited lecture on “Effects of early life stress and nutrition on later brain plasticity and disease vulnerability” at the MQ mental health meeting, London, 2 feb 2018.
    36.    Invited lecture “Brain plasticity in relation to (early) stress, nutrition and depression’, at the Institute Italiano di Tecnologica in Genova, Italy (host; Dr Davide die Pietri Tonelli), 17 May 2018.
    37.    Invited Lecture “Neurogenesis, (early) stress and depression’ at the Dutch Neuroscience Meeting, Lunteren, 7th June 2018. 
    38.    Invited lecture ‘Highlights in Dementia’ at the ECNP meeting in Barcelona, 7 Oct 2018.
    39.    Opening talk at the  session ‘Update on Huntington’s and Parkinson’s disease treatment’, at the ECNP meeting, 9th Oct 2018.  
    40.    Lecture on ‘Brain Plasticity’ at the University of Edinburgh, Scotland (host Prof.Dr. J. Seckl), 26th Oct 2018.

    2019;
    41.    Invited Lecture; ‘Brain plasticity in relation to early life stress, nutrition and major depression’, on the occasion of the PhD viva of Danka Kozareva at University College Cork, Ireland, hosts Dr. Y Nolan and Prof.Dr. J Cryan, 28th Jan 2019.
    42.    Invited Lecture; ‘Brain plasticity and neurogenesis in relation to early life stress, nutrition, depression and dementia’, at Neuroscience & Mental Health Research Institute, School of Biosciences, Cardiff University, Cardiff, UK, host Prof.Dr. S Trent, Prof.Dr. J Hall, 14th Feb 2019.
    43.   Invited Lecture as part of UvA Health Week; ‘What does stress do to your brain?’ UvA, Science Park, 14th May 2019.
    44.   Invited Lecture ‘Brain Plasticity in relation to (early) stress, nutrition and depression’. Host; Prof.dr. Eleanor Coffey, Turku Centre for Biotechnology, University of Turku and Department of Biosciences, Åbo Akademi University Åbo, Turku, Finland, 17th May 2019. 
    45.  Lecture  ‘Brain plasticity in relation to early life stress, nutrition and dementia”, Eurogenesis meeting 14th June 2019, Bordeaux, France.

    46.  Invited Lecture on; ‘Cognitive reserve and plasticity from a neurobiological perspective; focus on early life’ at the Cognitive Reserve Symposium at the Veranda, host Dr Rik Ossenkoppele and Prof.Dr. W vd Flier, Alzheimer Centrum, Amsterdam, 18 sept 2019.

    47.  Invited talk on; ‘Brain plasticity in relation to (early life) stress, nutrition and dementia’, host; Prof.Dr. P. Riederer, International WASAD congress, Wuerzburg Germany, 5 Oktober 2019.

    48.  Invited lecture; ‘Neurobiology of Alzheimer’s disease; recent developments’, (host Dr. I. Philippens) at TNO BPRS Rijswijk, 19 nov 2019.

    49.  Outreach lecture (in Dutch) in the framework of the ‘Inspiratie week’; ‘Hersenonderzoek in de praktijk', for 3 HV students, Montessori Scholengemeenschap Amsterdam, 21 Nov 2019.

    50. Outreach Lecture (in Dutch) on 'What is brain research about these days?', for 4 VWO students at the Herman Wesselink College in Amstelveen, 18 Dec 2019.

  • Publicaties

    2020

    • Lucassen, P. J., Fitzsimons, C. P., Salta, E., & Maletic-Savatic, M. (2020). Adult neurogenesis, human after all (again): Classic, optimized, and future approaches. Behavioural Brain Research, 381, 112458. https://doi.org/10.1016/j.bbr.2019.112458
    • Zhang, L., Verwer, R. W. H., Lucassen, P. J., Huitinga, I., & Swaab, D. F. (2020). Prefrontal cortex alterations in glia gene expression in schizophrenia with and without suicide. Journal of Psychiatric Research, 121, 31-38. https://doi.org/10.1016/j.jpsychires.2019.11.002 [details]

    2019

    2018

    • Gao, S., Zhang, T., Jin, L., Liang, D., Fan, G., Song, Y., ... Swaab, D. F. (2018). CAPON Is a Critical Protein in Synaptic Molecular Networks in the Prefrontal Cortex of Mood Disorder Patients and Contributes to Depression-Like Behavior in a Mouse Model. Cerebral Cortex, [bhy254]. https://doi.org/10.1093/cercor/bhy254 [details]
    • Hoeijmakers, L., Amelianchik, A., Verhaag, F., Kotah, J., Lucassen, P. J., & Korosi, A. (2018). Early-Life Stress Does Not Aggravate Spatial Memory or the Process of Hippocampal Neurogenesis in Adult and Middle-Aged APP/PS1 Mice. Frontiers in Aging Neuroscience, 10, [61]. https://doi.org/10.3389/fnagi.2018.00061 [details]
    • Hoeijmakers, L., Lesuis, S. L., Krugers, H., Lucassen, P. J., & Korosi, A. (2018). A preclinical perspective on the enhanced vulnerability to Alzheimer's disease after early-life stress. Neurobiology of Stress, 8, 172-185. https://doi.org/10.1016/j.ynstr.2018.02.003 [details]
    • Hoeijmakers, L., Meerhoff, G. F., de Vries, J. W., Ruigrok, S. R., van Dam, A-M., van Leuven, F., ... Lucassen, P. J. (2018). The age-related slow increase in amyloid pathology in APP.V717I mice activates microglia, but does not alter hippocampal neurogenesis. Neurobiology of Aging, 61, 112-123. https://doi.org/10.1016/j.neurobiolaging.2017.09.013 [details]
    • Kempermann, G., Gage, F. H., Aigner, L., Song, H., Curtis, M. A., Thuret, S., ... Frisén, J. (2018). Human Adult Neurogenesis: Evidence and Remaining Questions. Cell Stem Cell, 23(1), 25-30. https://doi.org/10.1016/j.stem.2018.04.004 [details]
    • Lesuis, S. L., Catsburg, L. A. E., Lucassen, P. J., & Krugers, H. J. (2018). Effects of corticosterone on mild auditory fear conditioning and extinction; role of sex and training paradigm. Learning & Memory, 25(10), 544-549. https://doi.org/10.1101/lm.047811.118 [details]
    • Lesuis, S. L., Hoeijmakers, L., Korosi, A., de Rooij, S. R., Swaab, D. F., Kessels, H. W., ... Krugers, H. J. (2018). Vulnerability and resilience to Alzheimer's disease: early life conditions modulate neuropathology and determine cognitive reserve. Alzheimer's Research & Therapy, 10, [95]. https://doi.org/10.1186/s13195-018-0422-7 [details]
    • Lesuis, S. L., Weggen, S., Baches, S., Lucassen, P. J., & Krugers, H. J. (2018). Targeting glucocorticoid receptors prevents the effects of early life stress on amyloid pathology and cognitive performance in APP/PS1 mice. Translational Psychiatry, 8, [53]. https://doi.org/10.1038/s41398-018-0101-2 [details]
    • Meerhoff, G. F., Vester, S. M., Hesseling, P., Klaassen, S. D., Cornelissen, A. S., Lucassen, P. J., & Joosen, M. J. A. (2018). Potentiation of antiseizure and neuroprotective efficacy of standard nerve agent treatment by addition of tariquidar. Neurotoxicology, 68, 167-176. https://doi.org/10.1016/j.neuro.2018.08.005 [details]
    • Motta-Teixeira, L. C., Machado-Nils, A. V., Battagello, D. S., Diniz, G. B., Andrade-Silva, J., Silva Jr., S., ... Cipolla-Neto, J. (2018). The absence of maternal pineal melatonin rhythm during pregnancy and lactation impairs offspring physical growth, neurodevelopment, and behavior. Hormones and Behavior, 105, 146-156. https://doi.org/10.1016/j.yhbeh.2018.08.006 [details]
    • Schrantee, A., Lucassen, P. J., Booij, J., & Reneman, L. (2018). Serotonin transporter occupancy by the SSRI citalopram predicts default-mode network connectivity. European Neuropsychopharmacology, 28(10), 1173-1179. https://doi.org/10.1016/j.euroneuro.2018.07.099 [details]
    • Zhao, J., Verwer, R. W. H., Gao, S-F., Qi, X-R., Lucassen, P. J., Kessels, H. W., & Swaab, D. F. (2018). Prefrontal alterations in GABAergic and glutamatergic gene expression in relation to depression and suicide. Journal of Psychiatric Research, 102, 261-274. https://doi.org/10.1016/j.jpsychires.2018.04.020 [details]
    • van Campen, J. S., Hessel, E. V. S., Bohmbach, K., Rizzi, G., Lucassen, P. J., Lakshmi Turimella, S., ... Joëls, M. (2018). Stress and Corticosteroids Aggravate Morphological Changes in the Dentate Gyrus after Early-Life Experimental Febrile Seizures in Mice. Frontiers in Endocrinology, 9, [3]. https://doi.org/10.3389/fendo.2018.00003 [details]

    2017

    • Abbink, M. R., Naninck, E. F. G., Lucassen, P. J., & Korosi, A. (2017). Early-life stress diminishes the increase in neurogenesis after exercise in adult female mice. Hippocampus, 27(8), 839-844. https://doi.org/10.1002/hipo.22745 [details]
    • Bielefeld, P., Schouten, M., Lucassen, P. J., & Fitzsimons, C. P. (2017). Transcription factor oscillations in neural stem cells: implications for accurate control of gene expression. Neurogenesis, 4(1), [e1262934]. https://doi.org/10.1080/23262133.2016.1262934 [details]
    • Hoeijmakers, L., Ruigrok, S. R., Amelianchik, A., Ivan, D., van Dam, A-M., Lucassen, P. J., & Korosi, A. (2017). Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer's disease mouse model. Brain, behavior, and immunity, 63, 160-175. https://doi.org/10.1016/j.bbi.2016.12.023 [details]
    • Krugers, H. J., Arp, J. M., Xiong, H., Kanatsou, S., Lesuis, S. L., Korosi, A., ... Lucassen, P. J. (2017). Early life adversity: Lasting consequences for emotional learning. Neurobiology of Stress, 6, 14-21. https://doi.org/10.1016/j.ynstr.2016.11.005 [details]
    • Lesuis, S. L., van Hoek, B. A. C. E., Lucassen, P. J., & Krugers, H. J. (2017). Early postnatal handling reduces hippocampal amyloid plaque formation and enhances cognitive performance in APPswe/PS1dE9 mice at middle age. Neurobiology of Learning and Memory, 144, 27-35. https://doi.org/10.1016/j.nlm.2017.05.016 [details]
    • Loi, M., Mossink, J. C. L., Meerhoff, G. F., Den Blaauwen, J. L., Lucassen, P. J., & Joëls, M. (2017). Effects of early-life stress on cognitive function and hippocampal structure in female rodents. Neuroscience, 342, 101-119. https://doi.org/10.1016/j.neuroscience.2015.08.024 [details]
    • Lucassen, P. J., Korosi, A., Krugers, H. J., & Oomen, C. A. (2017). Early life stress- and sex-dependent effects on hippocampal neurogenesis. In G. Fink (Ed.), Stress: Neuroendocrinology and Neurobiology [135–146] (Handbook of Stress; Vol. 2). Amsterdam: Academic Press. https://doi.org/10.1016/B978-0-12-802175-0.00013-9 [details]
    • Naninck, E. F. G., Oosterink, J. E., Yam, K-Y., de Vries, L. P., Schierbeek, H., van Goudoever, J. B., ... Korosi, A. (2017). Early micronutrient supplementation protects against early stress-induced cognitive impairments. The FASEB Journal, 31(2), 505-518. https://doi.org/10.1096/fj.201600834R [details]
    • Schrantee, A., Tremoleda, J. L., Wylezinska-Arridge, M., Bouet, V., Hesseling, P., Meerhoff, G. F., ... Reneman, L. (2017). Repeated dexamphetamine treatment alters the dopaminergic system and increases the phMRI response to methylphenidate. PLoS ONE, 12(2), [e0172776]. https://doi.org/10.1371/journal.pone.0172776 [details]
    • Solleveld, M. M., Schrantee, A., Puts, N. A. J., Reneman, L., & Lucassen, P. J. (2017). Age-dependent, lasting effects of methylphenidate on the GABAergic system of ADHD patients. NeuroImage: Clinical, 15, 812-818. https://doi.org/10.1016/j.nicl.2017.06.003 [details]
    • Walker, C-D., Bath, K. G., Joels, M., Korosi, A., Larauche, M., Lucassen, P. J., ... Baram, T. Z. (2017). Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential. Stress - the International Journal on the Biology of Stress, 20(5), 421-448. https://doi.org/10.1080/10253890.2017.1343296 [details]
    • Yam, K. Y., Naninck, E. F. G., Abbink, M. R., la Fleur, S. E., Schipper, L., van den Beukel, J. C., ... Korosi, A. (2017). Exposure to chronic early-life stress lastingly alters the adipose tissue, the leptin system and changes the vulnerability to western-style diet later in life in mice. Psychoneuroendocrinology, 77, 186-195. https://doi.org/10.1016/j.psyneuen.2016.12.012 [details]
    • Yam, K. Y., Ruigrok, S. R., Ziko, I., De Luca, S. N., Lucassen, P. J., Spencer, S. J., & Korosi, A. (2017). Ghrelin and hypothalamic NPY/AgRP expression in mice are affected by chronic early-life stress exposure in a sex-specific manner. Psychoneuroendocrinology, 86, 73-77. https://doi.org/10.1016/j.psyneuen.2017.09.006 [details]

    2016

    • Fitzsimons, C. P., Herbert, J., Schouten, M., Meijer, O. C., Lucassen, P. J., & Lightman, S. (2016). Circadian and ultradian glucocorticoid rhythmicity: Implications for the effects of glucocorticoids on neural stem cells and adult hippocampal neurogenesis. Frontiers in Neuroendocrinology, 41, 44-58. https://doi.org/10.1210/en.2012-1484 [details]
    • Herbert, J., & Lucassen, P. J. (2016). Depression as a risk factor for Alzheimer's disease: Genes, steroids, cytokines and neurogenesis - what do we need to know? Frontiers in Neuroendocrinology, 41, 153-171. https://doi.org/10.1016/j.yfrne.2015.12.001 [details]
    • Hoeijmakers, L., Heinen, Y., van Dam, A-M., Lucassen, P. J., & Korosi, A. (2016). Microglial priming and Alzheimer’s disease: a possible role for (early) immune challenges and epigenetics? Frontiers in Human Neuroscience, 10, [398]. https://doi.org/10.3389/fnhum.2016.00398 [details]
    • Hu, P., Wang, Y., Liu, J., Meng, F. T., Qi, X. R., Chen, L., ... Zhou, J. N. (2016). Chronic retinoic acid treatment suppresses adult hippocampal neurogenesis, in close correlation with depressive-like behavior. Hippocampus, 26(7), 911-923. https://doi.org/10.1002/hipo.22574 [details]
    • Kandola, A., Hendrikse, J., Lucassen, P. J., & Yücel, M. (2016). Aerobic exercise as a tool to improve hippocampal plasticity and function in humans: practical implications for mental health treatment. Frontiers in Human Neuroscience, 10, [373]. https://doi.org/10.3389/fnhum.2016.00373 [details]
    • Lesuis, S. L., Maurin, H., Borghgraef, P., Lucassen, P. J., Van Leuven, F., & Krugers, H. J. (2016). Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer’s disease. Oncotarget, 7(26), 39118-39135. https://doi.org/10.18632/oncotarget.9776 [details]
    • Lucassen, P. J., & Oomen, C. A. (2016). Stress, hippocampal neurogenesis and cognition: functional correlations. Frontiers in Biology, 11(3), 182-192. https://doi.org/10.1007/s11515-016-1412-4 [details]
    • Lucassen, P. J., Oomen, C. A., Naninck, E. F. G., Fitzsimons, C. P., van Dam, A-M., Czeh, B., & Korosi, A. (2016). Regulation of adult neurogenesis and plasticity by (early) stress, glucocorticoids and inflammation. In F. H. Gage, G. Kempermann, & H. Song (Eds.), Neurogenesis: a subject collection from Cold Spring Harbor Perspectives in Biology (pp. 255-270). (Cold Spring Harbor perspectives in biology). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/cshperspect.a021303 [details]
    • Lucassen, P. J., Oomen, C. A., Schouten, M., Encinas, J. M., & Fitzsimons, C. P. (2016). Adult Neurogenesis, Chronic Stress and Depression. In J. J. Canales (Ed.), Adult neurogenesis in the hippocampus: health, psychopathology, and brain disease (pp. 177-206). London: Academic Press. https://doi.org/10.1016/B978-0-12-801977-1.00008-8 [details]
    • Reemst, K., Noctor, S. C., Lucassen, P. J., & Hol, E. M. (2016). The Indispensable Roles of Microglia and Astrocytes during Brain Development. Frontiers in Human Neuroscience, 10, [566]. https://doi.org/10.3389/fnhum.2016.00566 [details]
    • Schouten, M., Bielefeld, P., Fratantoni, S. A., Hubens, C. J., Piersma, S. R., Pham, T. V., ... Fitzsimons, C. P. (2016). Multi-omics profile of the mouse dentate gyrus after kainic acid induced status epilepticus. Scientific Data, 3, [160068]. https://doi.org/10.1038/sdata.2016.68 [details]
    • Schrantee, A., Tamminga, H. G. H., Bouziane, C., Bottelier, M. A., Bron, E. E., Mutsaerts, H-JMM., ... Reneman, L. (2016). Age-Dependent Effects of Methylphenidate on the Human Dopaminergic System in Young vs Adult Patients With Attention-Deficit/Hyperactivity Disorder: A Randomized Clincal Trial. JAMA Psychiatry, 73(9), 955-962. https://doi.org/10.1001/jamapsychiatry.2016.1572 [details]
    • Zhao, J., Verwer, R. W. H., van Wamelen, D. J., Qi, X. R., Gao, S. F., Lucassen, P. J., & Swaab, D. F. (2016). Prefrontal changes in the glutamate-glutamine cycle and neuronal/glial glutamate transporters in depression with and without suicide. Journal of Psychiatric Research, 82, 8-15. https://doi.org/10.1016/j.jpsychires.2016.06.017 [details]

    2015

    2014

    • Bielefeld, P., van Vliet, E. A., Gorter, J. A., Lucassen, P. J., & Fitzsimons, C. P. (2014). Different subsets of newborn granule cells: a possible role in epileptogenesis? European Journal of Neuroscience, 39(1), 1-11. https://doi.org/10.1111/ejn.12387 [details]
    • Boekhoorn, K., van Dis, V., Goedknegt, E., Sobel, A., Lucassen, P. J., & Hoogenraad, C. C. (2014). The microtubule destabilizing protein stathmin controls the transition from dividing neuronal precursors to postmitotic neurons during adult hippocampal neurogenesis. Developmental Neurobiology, 74(12), 1226-1242. https://doi.org/10.1002/dneu.22200 [details]
    • Doorn, K. J., Drukarch, B., van Dam, A-M., & Lucassen, P. J. (2014). Hippocampal Proliferation Is Increased in Presymptomatic Parkinson’s Disease and due to Microglia. Neural Plasticity, 2014, 959154. https://doi.org/10.1155/2014/959154 [details]
    • Doorn, K. J., Goudriaan, A., Blits-Huizinga, C., Bol, J. G. J. M., Rozemuller, A. J., Hoogland, P. V. J. M., ... van Dam, A-M. (2014). Increased Amoeboid Microglial Density in the Olfactory Bulb of Parkinson's and Alzheimer's Patients. Brain Pathology, 24(2), 152-165. https://doi.org/10.1111/bpa.12088 [details]
    • Doorn, K. J., Moors, T., Drukarch, B., van de Berg, W. D. J., Lucassen, P. J., & van Dam, A-M. (2014). Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson's disease patients. Acta Neuropathologica Communications, 2, 90. https://doi.org/10.1186/s40478-014-0090-1 [details]
    • Fitzsimons, C. P., van Bodegraven, E., Schouten, M., Lardenoije, R., Kompotis, K., Kenis, G., ... Rutten, B. P. F. (2014). Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease. Molecular Neurodegeneration, 9, 25. https://doi.org/10.1186/1750-1326-9-25 [details]
    • Hoeijmakers, L., Harbich, D., Schmid, B., Lucassen, P. J., Wagner, K. V., Schmidt, M. V., & Hartmann, J. (2014). Depletion of FKBP51 in female mice shapes HPA axis activity. PLoS ONE, 9(4), e95796. https://doi.org/10.1371/journal.pone.0095796 [details]
    • Hoeijmakers, L., Lucassen, P. J., & Korosi, A. (2014). The interplay of early-life stress, nutrition, and immune activation programs adult hippocampal structure and function. Frontiers in Molecular Neuroscience, 7, 103. https://doi.org/10.3389/fnmol.2014.00103 [details]
    • Klomp, A., Václavů, L., Meerhoff, G. F., Reneman, L., & Lucassen, P. J. (2014). Effects of chronic fluoxetine treatment on neurogenesis and tryptophan hydroxylase expression in adolescent and adult rats. PLoS ONE, 9(5), [e97603]. https://doi.org/10.1371/journal.pone.0097603 [details]
    • Loi, M., Koricka, S., Lucassen, P. J., & Joëls, M. (2014). Age- and sex-dependent effects of early life stress on hippocampal neurogenesis. Frontiers in Endocrinology, 5, [13]. https://doi.org/10.3389/fendo.2014.00013 [details]
    • Lucassen, P. J., Pruessner, J., Sousa, N., Almeida, O. F. X., van Dam, A. M., Rajkowska, G., ... Czéh, B. (2014). Neuropathology of stress. Acta Neuropathologica, 127(1), 109-135. https://doi.org/10.1007/s00401-013-1223-5 [details]
    • Marlatt, M. W., Bauer, J., Aronica, E., van Haastert, E. S., Hoozemans, J. J. M., Joels, M., & Lucassen, P. J. (2014). Proliferation in the Alzheimer hippocampus is due to microglia, not astroglia, and occurs at sites of amyloid deposition. Neural Plasticity, 2014, 693851. https://doi.org/10.1155/2014/693851 [details]
    • Wang, Q., Verweij, E. W. E., Krugers, H. J., Joels, M., Swaab, D. F., & Lucassen, P. J. (2014). Distribution of the glucocorticoid receptor in the human amygdala; changes in mood disorder patients. Brain Structure and Function, 219(5), 1615-1626. https://doi.org/10.1007/s00429-013-0589-4 [details]
    • van der Marel, K., Klomp, A., Meerhoff, G. F., Schipper, P., Lucassen, P. J., Homberg, J. R., ... Reneman, L. (2014). Long-Term Oral Methylphenidate Treatment in Adolescent and Adult Rats: Differential Effects on Brain Morphology and Function. Neuropsychopharmacology, 39(2), 263-273. https://doi.org/10.1038/npp.2013.169 [details]

    2013

    2012

    • Claessens, S. E. F., Belanoff, J. K., Kanatsou, S., Lucassen, P. J., Champagne, D. L., & de Kloet, E. R. (2012). Acute effects of neonatal dexamethasone treatment on proliferation and astrocyte immunoreactivity in hippocampus and corpus callosum: Towards a rescue strategy. Brain Research, 1482, 1-12. https://doi.org/10.1016/j.brainres.2012.08.017 [details]
    • Datson, N. A., Speksnijder, N., Mayer, J. L., Steenbergen, P. J., Korobko, O., Goeman, J., ... Lucassen, P. J. (2012). The transcriptional response to chronic stress and glucocorticoid receptor blockade in the hippocampal dentate gyrus. Hippocampus, 22(2), 359-371. https://doi.org/10.1002/hipo.20905 [details]
    • Doorn, K. J., Lucassen, P. J., Boddeke, H. W., Prins, M., Berendse, H. W., Drukarch, B., & van Dam, A. M. (2012). Emerging roles of microglial activation and non-motor symptoms in Parkinson's disease. Progress in Neurobiology, 98(2), 222-238. https://doi.org/10.1016/j.pneurobio.2012.06.005 [details]
    • Fitzsimons, C. P., Vreugdenhil, E., & Lucassen, P. J. (2012). Inhibition of Adult Neurogenesis through ERK5 knockdown Impairs Complex Hippocampus-dependent Spatial Memory Tasks. Future Neurology, 7(5), 531-535. https://doi.org/10.2217/fnl.12.55 [details]
    • Hu, P., Oomen, C., van Dam, A. M., Wester, J., Zhou, J. N., Joëls, M., & Lucassen, P. J. (2012). A single-day treatment with mifepristone is sufficient to normalize chronic glucocorticoid induced suppression of hippocampal cell proliferation. PLoS ONE, 7(9), [e46224]. https://doi.org/10.1371/journal.pone.0046224 [details]
    • Korosi, A., Naninck, E. F. G., Oomen, C. A., Schouten, M., Krugers, H., Fitzsimons, C., & Lucassen, P. J. (2012). Early-life stress mediated modulation of adult neurogenesis and behavior. Behavioural Brain Research, 227(2), 400-409. https://doi.org/10.1016/j.bbr.2011.07.037 [details]
    • Krugers, H. J., Oomen, C. A., Gumbs, M., Li, M., Velzing, E. H., Joëls, M., & Lucassen, P. J. (2012). Maternal deprivation and dendritic complexity in the basolateral amygdala. Neuropharmacology, 62(1), 534-537. https://doi.org/10.1016/j.neuropharm.2011.09.022 [details]
    • Lucassen, P. J. (2012). Chemotherapy modulates specific aspects of cognition parallel to neurogenesis (Commentary on Nokia et al.). European Journal of Neuroscience, 36, 3519-3520. https://doi.org/10.1111/ejn.12056 [details]
    • Marlatt, M. W., Potter, M. C., Lucassen, P. J., & van Praag, H. (2012). Running throughout middle-age improves memory function, hippocampal neurogenesis and BDNF levels in female C57Bl/6J mice. Developmental Neurobiology, 72(6), 943-952. https://doi.org/10.1002/dneu.22009 [details]
    • Saaltink, D. J., Håvik, B., Verissimo, C., Lucassen, P. J., & Vreugdenhil, E. (2012). Doublecortin and doublecortin-like are expressed in overlapping and non-overlapping neuronal cell population: implications for neurogenesis. The journal of comparative neurology, 520(13), 2805-2823. https://doi.org/10.1002/cne.23144 [details]
    • Schouten, M., Buijink, M. R., Lucassen, P. J., & Fitzsimons, C. P. (2012). New neurons in aging brains: molecular control by small non-coding RNAs. Frontiers in Neuroscience, 6, [25]. https://doi.org/10.3389/2Ffnins.2012.00025 [details]
    • Wang, Q., Joëls, M., Swaab, D. F., & Lucassen, P. J. (2012). Hippocampal GR expression is increased in elderly depressed females. Neuropharmacology, 62(1), 527-533. https://doi.org/10.1016/j.neuropharm.2011.09.014 [details]

    2011

    • Bruel-Jungerman, E., Lucassen, P. J., & Francis, F. (2011). Cholinergic influences on cortical development and adult neurogenesis. Behavioural Brain Research, 221(2), 379-388. https://doi.org/10.1016/j.bbr.2011.01.021 [details]
    • Eendebak, R. J. A. H., Lucassen, P. J., & Fitzsimons, C. P. (2011). Nuclear receptors and microRNAs: who regulates the regulators in neural stem cells? FEBS Letters, 585(5), 717-22. https://doi.org/10.1016/j.febslet.2011.01.039 [details]
    • Lemmens, M. A. M., Sierksma, A. S. R., Rutten, B. P. F., Dennissen, F., Steinbusch, H. W. M., Lucassen, P. J., & Schmitz, C. (2011). Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer's disease. Brain Structure and Function, 216(3), 227-237. https://doi.org/10.1007/s00429-011-0305-1 [details]
    • Lucassen, P. J., Fitzsimons, C. P., Vreugdenhil, E., Hu, P., Oomen, C., Revsin, Y., ... de Kloet, E. R. (2011). Regulation of structural plasticity and neurogenesis during stress and diabetes; protective effects of glucocorticoid receptor antagonists. In A. G. Gravanis, & S. H. Mellon (Eds.), Hormones in neurodegeneration, neuroprotection, and neurogenesis (pp. 103-120). Weinheim: Wiley-VCH. https://doi.org/10.1002/9783527633968.ch6 [details]
    • Marlatt, M. W., Philippens, I., Manders, E., Czeh, B., Joëls, M., Krugers, H., & Lucassen, P. J. (2011). Distinct structural plasticity in the hippocampus and amygdala of the middle-aged common marmoset (Callithrix jacchus). Experimental Neurology, 230(2), 291-301. https://doi.org/10.1016/j.expneurol.2011.05.008 [details]
    • Naninck, E. F. G., Lucassen, P. J., & Bakker, J. (2011). Sex differences in adolescent depression: do sex hormones determine vulnerability? Journal of Neuroendocrinology, 23(5), 383-392. https://doi.org/10.1111/j.1365-2826.2011.02125.x [details]
    • Novati, A., Hulshof, H. J., Koolhaas, J. M., Lucassen, P. J., & Meerlo, P. (2011). Chronic sleep restriction causes a decrease in hippocampal volume in adolescent rats, which is not explained by changes in glucocorticoid levels or neurogenesis. Neuroscience, 190, 145-155. https://doi.org/10.1016/j.neuroscience.2011.06.027 [details]
    • Oomen, C. A., Soeters, H., Audureau, N., Vermunt, L., van Hasselt, F. N., Manders, E. M. M., ... Lucassen, P. J. (2011). Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female rats. Psychopharmacology, 214(1), 249-260. https://doi.org/10.1007/s00213-010-1922-8 [details]
    • Van Bokhoven, P., Oomen, C. A., Hoogendijk, W. J., Smit, A. B., Lucassen, P. J., & Spijker, S. (2011). Reduction in hippocampal neurogenesis after social defeat is long-lasting and responsive to late antidepressant treatment. European Journal of Neuroscience, 33(10), 1833-1840. https://doi.org/10.1111/j.1460-9568.2011.07668.x [details]
    • Xiao, A. W., He, J., Wang, Q., Luo, Y., Sun, Y., Zhou, Y. P., ... Dai, J. P. (2011). The origin and development of plaques and phosphorylated tau are associated with axonopathy in Alzheimer's disease. Neuroscience bulletin, 27(5), 287-99. https://doi.org/10.1007/s12264-011-1736-7 [details]
    • van Tijn, P., Kamphuis, W., Marlatt, M. W., Hol, E. M., & Lucassen, P. J. (2011). Presenilin mouse and zebrafish models for dementia: Focus on neurogenesis. Progress in Neurobiology, 93(2), 149-164. https://doi.org/10.1016/j.pneurobio.2010.10.008 [details]

    2010

    • Christensen, D. Z., Schneider-Axmann, T., Lucassen, P. J., Bayer, T. A., & Wirths, O. (2010). Accumulation of intraneuronal Aβ correlates with ApoE4 genotype. Acta Neuropathologica, 119(5), 555-566. https://doi.org/10.1007/s00401-010-0666-1 [details]
    • Krugers, H. J., Lucassen, P. J., Karst, H., & Joëls, M. (2010). Chronic stress effects on hippocampal structure and synaptic function: relevance for depression and normalization by anti-glucocorticoid treatment. Frontiers in Synaptic Neuroscience, 2(24), 24. https://doi.org/10.3389/fnsyn.2010.00024 [details]
    • Lucassen, P. J., Meerlo, P., Naylor, A. S., van Dam, A. M., Dayer, A. G., Fuchs, E., ... Czéh, B. (2010). Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action. European Neuropsychopharmacology, 20(1), 1-17. https://doi.org/10.1016/j.euroneuro.2009.08.003 [details]
    • Lucassen, P. J., Stumpel, M. W., Wang, Q., & Aronica, E. (2010). Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients. Neuropharmacology, 58(6), 940-949. https://doi.org/10.1016/j.neuropharm.2010.01.012 [details]
    • Marlatt, M. W., & Lucassen, P. J. (2010). Neurogenesis and Alzheimer's disease: biology and pathophysiology in mice and men. Current Alzheimer Research, 7(2), 113-125. https://doi.org/10.2174/156720510790691362 [details]
    • Marlatt, M. W., Lucassen, P. J., & van Praag, H. (2010). Comparison of neurogenic effects of fluoxetine, duloxetine and running in mice. Brain Research, 1341, 93-99. https://doi.org/10.1016/j.brainres.2010.03.086 [details]
    • Oomen, C. A., Soeters, H., Audureau, N., Vermunt, L., van Hasselt, F. N., Manders, E. M. M., ... Krugers, H. (2010). Severe early life stress hampers spatial learning and neurogenesis, but improves hippocampal synaptic plasticity and emotional learning under high-stress conditions in adulthood. The Journal of Neuroscience, 30(19), 6635-6645. https://doi.org/10.1523/JNEUROSCI.0247-10.2010 [details]
    • Wirths, O., Bethge, T., Marcello, A., Harmeier, A., Jawhar, S., Lucassen, P. J., ... Bayer, T. A. (2010). Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases. Journal of Neural Transmission, 117(1), 85-96. https://doi.org/10.1007/s00702-009-0314-x [details]

    2009

    • Bao, A. M., Lucassen, P. J., & Swaab, D. F. (2009). Neuroendocrinology of psychiatric disorders. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 2641-2645). Berlin: Springer. [details]
    • Boekhoorn, K., & Lucassen, P. J. (2009). Nieuwe neuronen in volwassen hersenen. Tijdschrift voor Neuropsychiatrie & Gedragsneurologie, (juni), 119-123. [details]
    • Boer, K., Lucassen, P. J., Spliet, W. G. M., Vreugdenhil, E., van Rijen, P. C., Troost, D., ... Aronica, E. (2009). Doublecortin-like (DCL) expression in focal cortical dysplasia and cortical tubers. Epilepsia, 50(12), 2629-2637. https://doi.org/10.1111/j.1528-1167.2009.02191.x [details]
    • Joosen, M. J. A., Jousma, E., van den Boom, T. M., Kuijpers, W. C., Smit, A. B., Lucassen, P. J., & van Helden, H. P. M. (2009). Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning. Neurotoxicology, 30(1), 72-80. https://doi.org/10.1016/j.neuro.2008.11.010 [details]
    • Joëls, M., Krugers, H. J., Lucassen, P. J., & Karst, H. (2009). Corticosteroid effects on cellular physiology of limbic cells. Brain Research, 1293, 91-100. https://doi.org/10.1016/j.brainres.2009.03.036 [details]
    • Lucassen, P. J., & Swaab, D. F. (2009). Endocrine disorders of development and growth. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 1103-1106). Berlin: Springer. [details]
    • Lucassen, P. J., & Swaab, D. F. (2009). Hypothalamo-pituitary-adrenal axis, stress and depression. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 1892-1895). Berlin: Springer. [details]
    • Lucassen, P. J., Boekhoorn, K., & Francis, F. (2009). Cortical development - Disorders. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 894-896). Berlin: Springer. [details]
    • Lucassen, P. J., Bosch, O. J., Jousma, E., Krömer, S. A., Andrew, R., Seckl, J. R., & Neumann, I. D. (2009). Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: Possible key role of placental 11β-hydroxysteroid dehydrogenase type 2. European Journal of Neuroscience, 29(1), 97-103. https://doi.org/10.1111/j.1460-9568.2008.06543.x [details]
    • Lucassen, P. J., Meerlo, P., Naylor, A. S., van Dam, A. M., Dayer, A. G., Czeh, B., & Oomen, C. A. (2009). Do depression, stress, sleep disruption, and inflammation alter hippocampal apoptosis and neurogenesis? In C. M. Pariante (Ed.), Understanding depression: A translational approach (pp. 139-156). Oxford: Oxford University Press. [details]
    • Lucassen, P. J., Scheper, W., & van Someren, E. J. W. (2009). Adult neurogenesis and the unfolded protein response; new cellular and molecular avenues in sleep research. Sleep Medicine Reviews, 13(3), 183-186. https://doi.org/10.1016/j.smrv.2008.12.004 [details]
    • Marlatt, M. W., Hoozemans, J. J. M., Veerhuis, R., & Lucassen, P. J. (2009). Alzheimer’s disease and adult neurogenesis—Are endogenous stem cells part of the solution? US Neurology, 5(1), 12-14. [details]
    • Oomen, C. A., Girardi, C. E. N., Cahyadi, R., Verbeek, E. C., Krugers, H., Joëls, M., & Lucassen, P. J. (2009). Opposite effects of early maternal deprivation on neurogenesis in male versus female rats. PLoS ONE, 4(1), e3675. https://doi.org/10.1371/journal.pone.0003675 [details]
    • Swaab, D. F., & Lucassen, P. J. (2009). Drinking disorders and osmoregulation. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 1010-1014). Berlin: Springer. [details]
    • Swaab, D. F., & Lucassen, P. J. (2009). Hypothalamo-neurohypophysial system. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 1888-1892). Berlin: Springer. [details]
    • Swaab, D. F., & Lucassen, P. J. (2009). Neuroendocrinology of eating disorders. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 2635-2637). Berlin: Springer. [details]
    • Swaab, D. F., & Lucassen, P. J. (2009). Neuroendocrinology of tumors. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 2645-2648). Berlin: Springer. [details]
    • Swaab, D. F., & Lucassen, P. J. (2009). Neuroendocrinology. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 2631-2635). Berlin: Springer. [details]

    2008

    • Boekhoorn, K., Sarabdjitsingh, A., Kommerie, H., de Punder, K., Schouten, T., Lucassen, P. J., & Vreugdenhil, E. (2008). Doublecortin (DCX) and doublecortin-like (DCL) are differentially expressed in the early but not late stages of murine neocortical development. The journal of comparative neurology, 507(4), 1639-1652. https://doi.org/10.1002/cne.21646 [details]
    • Lucassen, P. J., Oomen, C., van Dam, A-M., & Czéh, B. (2008). Regulation of hippocampal neurogenesis by systemic factors including stress, glucocorticoids, sleep, and inflammation. In F. H. Gage, G. Kempermann, & H. Song (Eds.), Adult neurogenesis (pp. 363-396). (Cold Spring Harbor monograph series; Vol. 52). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. [details]
    • Marlatt, M. W., Lucassen, P. J., Perry, G., Smith, M. A., & Zhu, X. (2008). Alzheimer's disease: Cerebrovascular dysfunction, oxidative stress, and advanced clinical therapies. Journal of Alzheimer's Disease, 15(2), 199-210. [details]
    • Simic, G., Mladinov, M., Seso Simic, D., Jovanov Milosevic, N., Islam, A., Pajtak, A., ... Kruslin, B. (2008). Abnormal motoneuron migration, differentiation, and axon outgrowth in spinal muscular atrophy. Acta Neuropathologica, 115(3), 313-326. https://doi.org/10.1007/s00401-007-0327-1 [details]
    • Thompson, A., Boekhoorn, K., van Dam, A-M., & Lucassen, P. J. (2008). Changes in adult neurogenesis in neurodegenerative diseases: Cause or consequence? Genes Brain and Behavior, 7(s1), 28-42. https://doi.org/10.1111/j.1601-183X.2007.00379.x [details]

    2007

    • Czeh, B., & Lucassen, P. J. (2007). What causes the hippocampal volume decrease in depression? : Are neurogenesis, glial changes and apoptosis implicated? European archives of psychiatry and clinical neuroscience, 257, 250-260. https://doi.org/10.1007/s00406-007-0728-0 [details]
    • Joëls, M., Karst, H., Krugers, H., & Lucassen, P. J. (2007). Chronic stress: Implications for neuronal morphology, function and neurogenesis. Frontiers in Neuroendocrinology, 28(2), 72-96. https://doi.org/10.1016/j.yfrne.2007.04.001 [details]
    • Krugers, H., van der Linden, S., van Olst, E., Alfarez, D. N., Maslam, S., Lucassen, P. J., & Joëls, M. (2007). Dissociation between apoptosis, neurogenesis, and synaptic potentiation in the dentate gyrus of adrenalectomized rats. Synapse (New York), 61(4), 221-230. https://doi.org/10.1002/syn.20359 [details]
    • Kuhn, H. G., Cooper-Kuhn, C. M., Boekhoorn, K., & Lucassen, P. J. (2007). Changes in neurogenesis in dementia and Alzheimer mouse models: are they functionally relevant? European archives of psychiatry and clinical neuroscience, 257(5), 281-289. https://doi.org/10.1007/s00406-007-0732-4 [details]
    • Oomen, C. A., Mayer, J. L., de Kloet, E. R., Joëls, M., & Lucassen, P. J. (2007). Brief treatment with the glucocorticoid receptor antagonist mifepristone normalizes the reduction in neurogenesis after chronic stress. European Journal of Neuroscience, 26, 3395-3401. https://doi.org/10.1111/j.1460-9568.2007.05972.x [details]
    • Sennvik, K., Boekhoorn, K., Lasrado, R., Terwel, D., Verhaeghe, S., Korr, H., ... van Leuven, F. (2007). Tau-4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/knockout mice. The FASEB Journal, 21(9), 2149-2161. https://doi.org/10.1096/fj.06-7735com [details]
    • Veenema, A. H., de Kloet, E. R., de Wilde, M. C., Roelofs, A. J., Kawata, M., Buwalda, B., ... Lucassen, P. J. (2007). Differential effects of stress on adult hippocampal cell proliferation in low and high aggressive mice. Journal of Neuroendocrinology, 19(7), 489-498. https://doi.org/10.1111/j.1365-2826.2007.01555.x [details]
    • Verwer, R. W. H., Sluiter, A. A., Balesar, R. A., Baayen, J. C., Noske, D. P., Dirven, C. M., ... Swaab, D. F. (2007). Mature astrocytes in the adult human neocortex express the early neuronal marker doublecortin. Brain, 130, 3321-3335. https://doi.org/10.1093/brain/awm264 [details]
    • Vreugdenhil, E., Kolk, S. H., Boekhoorn, K., Fitzsimons, C. P., Schaaf, M., Schouten, T., ... Lucassen, P. J. (2007). Doublecortin-like, a microtubule-associated protein expressed in radial glia, is crucial for neuronal precursor division and radial process stability. European Journal of Neuroscience, 25(3), 635-648. https://doi.org/10.1111/j.1460-9568.2007.05318.x [details]

    2006

    • Boekhoorn, K., Joëls, M., & Lucassen, P. J. (2006). Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus. Neurobiology of Disease, 24, 1-14. https://doi.org/10.1016/j.nbd.2006.04.017 [details]
    • Boekhoorn, K., Terwel, D., Biemans, B., Borghgraef, P., Wiegert, O., Ramakers, G. J. A., ... Lucassen, P. J. (2006). Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy. The Journal of Neuroscience, 26(13), 3514-3523. https://doi.org/10.1523/JNEUROSCI.5425-05.2006 [details]
    • Lucassen, P. J., Heine, V. M., van der Beek, E., Wiegant, V., de Kloet, E. R., Joëls, M., ... Czeh, B. (2006). Stress, Depression and Hippocampal Apoptosis. CNS & neurological disorders drug targets, 5(5), 531-546. [details]
    • Mayer, J., Klumpers, L., Maslam, S., de Kloet, E. R., Joëls, M., & Lucassen, P. J. (2006). Brief treatment with the glucocorticoid receptor antagonist mifeprestone normalizes the corticosterone-induced reduction of adult hippocampal neurogenesis. Journal of Neuroendocrinology, 18, 1-3. https://doi.org/10.1111/j.1365-2826.2005.01361.x [details]
    • Rodriquez-Contrera, A., de Lange, R. P. J., Lucassen, P. J., & Borst, J. G. G. (2006). Branching of calyceal afferents during postnatal development in the rat auditory brainstem. The journal of comparative neurology, 496, 214-228. https://doi.org/10.1002/cne.20918 [details]

    2005

    • Heine, V. M., Zareno, J., Maslam, S., Joëls, M., & Lucassen, P. J. (2005). Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk-1 protein expression. European Journal of Neuroscience, 21, 1304-1314. https://doi.org/10.1111/j.1460-9568.2005.03951.x [details]
    • Lucassen, P. J. (2005). "Nuclei of the Human Hypothalamus", and "Neuropathology of the Human Hypothalamus and Adjacent Structures". Journal of Neuropathology and Experimental Neurology, 64(3), 260-261. [details]
    • Swaab, D. F., Bao, A. M., & Lucassen, P. J. (2005). The stress system in the human brain in depression and neurodegeneration. Ageing research reviews, 4, 141-194. https://doi.org/10.1016/j.arr.2005.03.003 [details]

    2004

    • Fuchs, E., Czeh, B., Kole, M., Michaelis, T., & Lucassen, P. J. (2004). Alterations of neuroplasticity in depression: the hippocampus and beyond. European Neuropsychopharmacology, 14, 481-490. [details]
    • Heine, V. M., Maslam, S., Joëls, M., & Lucassen, P. J. (2004). Increased P27KIP1 protein expression in the dentate gyrus of chronically stressed rats indicates G(1) arrest involvement. Neuroscience, 129, 593-601. https://doi.org/10.1016/j.neuroscience.2004.07.048 [details]
    • Heine, V. M., Maslam, S., Joëls, M., & Lucassen, P. J. (2004). Prominent decline of newborn of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in the absence of an age-related hypothalamus-pituitary-adrenal axis activation. Neurobiology of Aging, 25(3), 361-375. https://doi.org/10.1016/S0197-4580(03)00090-3 [details]
    • Heine, V. M., Maslam, S., Zareno, J., Joëls, M., & Lucassen, P. J. (2004). Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible. European Journal of Neuroscience, 19(1), 131-144. https://doi.org/10.1046/j.1460-9568.2003.03100.x [details]
    • Joëls, M., Karst, H., Alfarez, D. N., Heine, V. M., Qin, Y. J., van Riel, E., ... Krugers, H. (2004). Effects of chronic stress on structure and cell function in rat hippocampus and hypothalamus. Stress - the International Journal on the Biology of Stress, 7(4), 221-331. https://doi.org/10.1080/10253890500070005 [details]
    • Lucassen, P. J., Fuchs, E., & Czeh, B. (2004). Antidepressant treatment with tianeptine reduces apoptosis in the hippocampal dentate gyrus and temporal cortex. Biological Psychiatry, 15, 789-796. [details]
    • Nair, S. M., Karst, H., Bussemaker, H. J., Maslam, S., van Essen-Rumpf, L., Russell, G., ... Joels, M. (2004). Single Cell Gene Expression Profiles Associated with Apoptosis Resistance in Rat Dentate Gyrus. European Journal of Neuroscience, 20(12), 3233-3234. https://doi.org/10.1111/j.1460-9568.2004.03819.x [details]
    • Nair, S. M., Karst, H., Dumas, T., Philips, R., Sapolsky, R. M., Rumpff-van Essen, L., ... Joëls, M. (2004). Gene expression profiles associated with survival of individual rat dentate cells after endogenous corticosteroid deprivation. European Journal of Neuroscience, 20, 3233-3243. https://doi.org/10.1111/j.1460-9568.2004.03819.x [details]
    • van der Beek, E. M., Wiegant, V. M., Schouten, W. G., van Eerdenburg, F. J. C. M., Loijens, L. W. S., van der Plas, C., ... Lucassen, P. J. (2004). Neuronal number, volume, and apoptosis of the left dentate gyrus of chronically stressed pigs correlate negatively with basal saliva cortisol levels. Hippocampus, 14(6), 688-700. https://doi.org/10.1002/hipo.10213 [details]

    2003

    • Gorter, J. A., Goncalves Pereira, P. M., van Vliet, E. A., Aronica, E. M. A., Lopes da Silva, F. H., & Lucassen, P. J. (2003). Neuronal cell death in a rat model for mesial temporal lobe epilepsy is induced by the initial status epilepticus and not by later repeated spontaneous seizures. Epilepsia, 44, 647-658. https://doi.org/10.1046/j.1528-1157.2003.53902.x [details]
    • Qin, Y. J., Heine, V. M., Karst, H., Lucassen, P. J., & Joëls, M. (2003). Gene expression patterns in rat dentate granule cells: comparison between fresh and fixed tissue. Journal of Neuroscience Methods, 131, 205-211. https://doi.org/10.1016/j.jneumeth.2003.08.010 [details]
    • Rijk de, R. H., Schaaf, M., Stam, F. J., de Jong, I. M. E., Swaab, D. F., Ravid, R., ... Lucassen, P. J. (2003). Very low levels of the glucocorticoid receptor beta isoform in the human hippocampus as shown by Taqman RT-PCR and immunocytochemistry. Molecular Brain Research, 116, 17-26. https://doi.org/10.1016/S0169-328X(03)00209-2 [details]

    2002

    • Grootendorst, J., Kempes, M. M., Lucassen, P. J., Dalm, S., de Kloet, E. R., & Oitzl, M. S. (2002). Differential effect of corticosterone on spatial learning abilities in apolipoprotein E knockout and C57BL/6J mice. Brain Research, 953, 281-285. https://doi.org/10.1016/S0006-8993(02)03399-1 [details]
    • Lucassen, P. J., Heine, V. M., Boekhoorn, K., & Krugers, H. (2002). Neural Degeneration. In L. Nadel (Ed.), Encyclopedia of Cognitive Science (pp. 246-252). London: Nature Publishing Group. [details]

    2001

    • Fuchs, E., Flugge, G., Ohl, F., Lucassen, P. J., Vollmann-Honsdorf, G. K., & Michaelis, T. (2001). Psychosocial stress, glucocorticoids and structural alterations in the tree shrew hippocampus. Physiology & behavior, 73(3), 285-291. https://doi.org/10.1016/S0031-9384(01)00497-8 [details]
    • Karssen, A. M., Meijer, O. C., van der Sant, I. C., Lucassen, P. J., de Lange, E. C. M., de Boer, A. G. E. M., & de Kloet, E. R. (2001). Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain. Endocrinology, 142(6), 2686-2686. https://doi.org/10.1210/en.142.6.2686 [details]
    • Lucassen, P. J., & de Kloet, E. R. (2001). Glucocorticoids and the aging brain; cause or consequence? In P. Hof, & C. Mobbs (Eds.), Functional Neurobiology of Aging (pp. 883-905). Academic Press. [details]
    • Lucassen, P. J., Muller, M. B., Holsboer, F., Bauer, J., Holtrop, A., Wouda, J., ... Swaab, D. F. (2001). Hippocampal apoptosis in major depression in a minor event and absent from subareas at risk for glucocorticoid overexposure. The American Journal of Pathology, 158(2), 453-468. https://doi.org/10.1016/S0002-9440(10)63988-0 [details]
    • Lucassen, P. J., Vollmann-Honsdorf, G. K., Gleisberg, M., Czeh, B., de Kloet, E. R., & Fuchs, E. (2001). Chronic psichosocial stress differentially affects in hippocampal subregions and cortex of the adult tree shrew. European Journal of Neuroscience, 14(1), 161-166. https://doi.org/10.1046/j.0953-816x.2001.01629.x [details]
    • Müller, M. B., Lucassen, P. J., Yassouridis, A., Hoogendijk, W. J. G., Holsboer, F., & Swaab, D. F. (2001). Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus. European Journal of Neuroscience, 14, 1603-1612. https://doi.org/10.1046/j.0953-816x.2001.01784.x [details]

    2000

    • Simic, G., Lucassen, P. J., Krsnik, Z., Kruslin, B., Kostovic, I., Winblad, B., & Bogdanovi, N. (2000). NOS expression in reactive astrocytes correlates with increased cell death related DNA damage in the hippocampus and entorhinal cortex in Alzheimer's disease. Experimental Neurology, 165, 12-26. https://doi.org/10.1006/exnr.2000.7448 [details]
    • Simic, G., Seso-Simic, D., Lucassen, P. J., Islam, A., Krsnik, Z., Cviko, A., ... Kruslin, B. (2000). Ultrastructural analysis and TUNEL demonstrate motor neuron apoptosis in Werdnig-Hoffmann disease. Journal of Neuropathology and Experimental Neurology, 59, 398-407. https://doi.org/10.1093/jnen/59.5.398 [details]

    1997

    2019

    2015

    • Kanatsou, S., Fearey, B. C., Kuil, L. E., Lucassen, P. J., Harris, A. P., Seckl, J. R., ... Joels, M. (2015). Correction: Overexpression of Mineralocorticoid Receptors Partially Prevents Chronic Stress-Induced Reductions in Hippocampal Memory and Structural Plasticity. PLoS ONE, 10(12), [e0145706]. https://doi.org/10.1371/journal.pone.0145706

    2014

    • Kuipers, S. D., Bramham, C. R., Cameron, H. A., Fitzsimons, C. P., Korosi, A., & Lucassen, P. J. (2014). Environmental Control of Adult Neurogenesis: From Hippocampal Homeostasis to Behavior and Disease. Neural Plasticity, 2014, 808643. https://doi.org/10.1155/2014/808643 [details]

    2004

    2015

    2008

    • Lucassen, P. J., Verbeek, E. C., & Oomen, C. A. (2008). Wat doen die nieuwe hersencellen daar? Neurogenese en celdood in volwassen hersenen. BLIND : Interdisciplinair Tijdschrift, 15. [details]

    2000

    • Lucassen, P. J., Negoescou, A., Labat-Moleur, F., & van Lookeren Campagne, M. (2000). Microwave enhanced in situ end labelling of apoptotic cells in tissue sections; pitfalls and possibilities. In J. G. C.R. Taylor S.R. Shi (Ed.), Antigen Retrieval Techniques (Biotechniques series Natick: Eaton Publishing.

    Lidmaatschap

    • Lucassen, P. J. (2017). Invited international Faculty Opponent for the PhD thesis of C Von Lindow, promotor; Prof.dr. B. Finsen and Prof.Dr. M West, Aarhus University.
    • Lucassen, P. J. (2016-). Fellow and Programme committee member ECNP, ECNP.
    • Lucassen, P. J. (2016-). Review panel member for Research Council Norway ., Research Council Norway.
    • Lucassen, P. J. (2016-). Review panel member for Donders Institute, Donders Institute.
    • Lucassen, P. J. (2016-). Review panel member for ABC, Amsterdam Brain and Cognition UvA.
    • Lucassen, P. J. (2016-). Review panel member for ANR, ANR.
    • Lucassen, P. J. (2016-). Review panel member for SFI, SFI.
    • Lucassen, P. J. (2016-2017). Chairman of the Scientific Advisory Board of the Campagneteam Huntington, Huntington.
    • Lucassen, P. J. (2016-2017). Chairman of the Scientific Advisory Board, Alzheimer Nederland.

    Mediaoptreden

    • Lucassen, P. J. (08-02-2017). plastic adult brain [Radio] Radio 1 NOS. plastic adult brain.
    • Lucassen, P. J. (27-07-2016). Neurogenesis and Exercise [Radio] http://www.nporadio1.nl/sportzomer-2016/onderwerpen/367580-bewegen-stimuleert-aanmaak-hersencellen. Neurogenesis and Exercise.
    • Lucassen, P. J. (01-01-2015). Nieuwe cellen, nieuwe verbindingen [Print]. Nieuwe cellen, nieuwe verbindingen.

    Tijdschriftredactie

    • Lucassen, P. J. (editor) (2016-2017). Stress - the International Journal on the Biology of Stress (Journal).
    • Lucassen, P. J. (editor) (2016-2017). PLoS ONE (Journal).
    • Lucassen, P. J. (editor) (2016-2017). Neuroscience (Journal).
    • Lucassen, P. J. (editor) (2016-). Brain Plasticity (Journal).
    • Lucassen, P. J. (editor) (2015). Stress - the International Journal on the Biology of Stress (Journal).
    • Lucassen, P. J. (editor) (2015). Neuroscience (Journal).
    • Lucassen, P. J. (editor) (2015). PLoS ONE (Journal).
    • Lucassen, P. J. (editor) (2014). Neuroscience (Journal).
    • Lucassen, P. J. (editor) (2014). Stress - the International Journal on the Biology of Stress (Journal).
    • Lucassen, P. J. (editor) (2014). Neural Plasticity (Journal).
    • Lucassen, P. J. (editor) (2010). Translational Neuroscience (Journal).
    • Lucassen, P. J. (editor) (2010). Frontiers in Neuroscience (Journal).
    • Lucassen, P. J. (editor) (2009). Frontiers in Neuroscience (Journal).

    Spreker

    • Lucassen, P. J. (speaker) (28-1-2019). Brain plasticity in relation to early life stress, nutrition and major depression’, University College Cork.
    • Lucassen, P. J. (speaker) (8-10-2018). The latest developments in Alzheimer’s research in his Highlight on Dementia., 31st ECNP Congress - Barcelona 2018, Barcelona, Spain.
    • Lucassen, P. J. (invited speaker) (7-6-2018). Neurogenesis, (early) stress and depression, Dutch Neuroscience Meeting, Lunteren, Netherlands.
    • Lucassen, P. J. (invited speaker) (17-5-2018). Brain plasticity in relation to (early) stress, nutrition and depression’, Institute Italiano di Tecnologica in Genova.
    • Lucassen, P. J. (invited speaker) (2-2-2018). Effects of early life stress and nutrition on later brain plasticity and disease vulnerability., MQ mental health meeting, London, 2 feb 2018, Londen, United Kingdom.
    • Lucassen, P. J. (speaker) (31-10-2017). Our brain under stress., Academic Medical Center (AMC).
    • Lucassen, P. J. (speaker) (25-10-2017). Stem cells, hippocampal neurogenesis, stress and depression., Department of Psychiatry Athens.
    • Lucassen, P. J. (speaker) (24-10-2017). New neurons in, and for, adult brains; environmental regulation and functional roles., Athens University.
    • Lucassen, P. J. (speaker) (5-9-2017). 'Exercise and psychiatric disease; should patients take the challenge?, 30th ECNP Congress - Paris 2017, Paris, France.
    • Lucassen, P. J. (speaker) (30-5-2017). Stress effects on the brain, Pawlik Congres – 'Presteren onder Druk', Amsterdam, Netherlands.
    • Lucassen, P. J. (speaker) (20-5-2017). Regulation of neurogenesis by stress and antidepressants., Adult primate neurogenesis, Varna, Bulgaria.
    • Lucassen, P. J. (speaker) (9-3-2017). Structural plasticity in relation to depression and dementia., Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark.
    • Lucassen, P. J. (speaker) (7-2-2017). An overview of Alzheimer research; the state of the affairs, Netherlands Institute for Neuroscience NIN - KNAW.
    • Lucassen, P. J. (speaker) (20-1-2017). Structural hippocampal plasticity and neurogenesis in relation to dementia, Alzheimer Center, Free University Medical Center, Amsterdam.
    • Lucassen, P. J. (speaker) (2-12-2016). Neurogenesis and Alzheimer, Neurodegeneration symposium, Maastricht, Netherlands.
    • Lucassen, P. J. (invited speaker) (10-9-2016). Hippocampal plasticity, (early) stress and depression., Invited lecture at ISPNE meeting ., Miami USA.
    • Lucassen, P. J. (invited speaker) (19-7-2016). (Early) stress effects on neurogenesis and plasticity., Invited lecture at the the meeting of the British Psychopharmacology Association (BAP),, Brighton, United Kingdom.
    • Lucassen, P. J. (invited speaker) (13-7-2016). Structural plasticity changes in relation to (early) stress, nutrition and depression, Invited lecture at 3rd Eurogenesis conference in Bordeaux, Bordeaux, France.
    • Lucassen, P. J. (invited speaker) (4-6-2016). Nieuwe zenuwcellen voor het volwassen brein., Invited University of Amsterdam lecture at the Universiteitsdag, location Oudemanhuispoort, Amsterdam, The Netherlands.
    • Lucassen, P. J. (invited speaker) (13-5-2016). New neurons in adult brains; an emerging substrate for brain plasticity programmed during early life., Invited plenary lecture at at the Spring conference on 'Neuroplasticity & Cognitive Reserve' of the Dutch Association for NeuroPsychology, (host; Prof.Dr. B. Schmand), Utrecht, The Netherlands.
    • Lucassen, P. J. (invited speaker) (25-4-2016). Structural plasticity and neurogenesis in relation to (early) stress, depression and dementia., Invited lecture at Department of Neuroscience, Universitat de Valencia, (host; Dr. J. Nacher)., Valencia, Spain.
    • Lucassen, P. J. (invited speaker) (13-4-2016). Round-Table Discussion on Chronic Early-Life Stress modelling, Invited participant/discussant Round Table Expert meeting on Early Life Stress, at the 'Neurobiology of Stress' conference, 12-14 April, Newport Beach, Irvine, USA.
    • Lucassen, P. J. (invited speaker) (15-3-2016). Ins and outs of Adult Neurogenesis., Invited lecture at 5th Biennial ICCTF Meeting, Netherlands Cancer Institute Amsterdam, (host; Dr. S. Schagen)., Amsterdam, The Netherlands.
    • Lucassen, P. J. (invited speaker) (22-1-2016). Hippocampal plasticity in relation to early stress, nutrition and depression., Invited lecture at 2016 IBRO Workshop, organized by the Hungarian Academy of Sciences., Budapest, Hungary.
    • Lucassen, P. J. (invited speaker) (14-1-2016). Plasticity changes in relation to (early) stress, depression and dementia., Invited lecture at Danish Academy, Aarhus University, Aarhuis, Denmark.
    • Lucassen, P. J. (speaker) (15-12-2015). Nieuwe cellen in het volwassen brein; stamcellen en sport., Invited lecture at at the Opening Symposium of the "Exercise and the brain" week (supported by the Cruyff foundation) at the Amstelveen College highschool, Amstelveen, The Netherlands.
    • Lucassen, P. J. (invited speaker) (16-11-2015). Early life stress, neurogenesis and behaviour., Invited lecture at the Colston Research Society Symposium 2015 on PTSD. Hosts; Prof.Dr. Hans Reul, prof.Dr. Astrid Linthorst, Bristol, United Kingdom.
    • Lucassen, P. J. (invited speaker) (1-10-2015). Structural plasticity in relation to early stress, nutrition and depression., Plenary lecture ECNP supported at the 8th Symposium Psiquiatria de Braga at the University of Minho, Braga, Portugal.
    • Lucassen, P. J. (invited speaker) (17-9-2015). Hippocampal plasticity in relation to (early) stress, nutrition and depression., Invited lecture at the Adult Neurogenesis meeting., Sernhac, France.
    • Lucassen, P. J. (invited speaker) (1-7-2015). Science matters; stress & stem cells., Invited lecture at the Biomedical Symposium Radboud Universiteit Nijmegen., Nijmegen, The Netherlands.
    • Lucassen, P. J. (invited speaker) (1-6-2015). Application of MRS as tool to measure adult neurogenesis in the live human brain., Invited lecture at ABC conference., Amsterdam, The Netherlands.
    • Lucassen, P. J. (invited speaker) (28-5-2015). Structural plasticity, (early) stress, antidepressants and major depression., Invited lecture at the symposium on the occasion of Dr Snezana Milanovic at the AMC., Amsterdam, The Netherlands.
    • Lucassen, P. J. (invited speaker) (10-4-2015). Structural plasticity in relation to (early) stress and depression., Invited lecture at the session on "Structural dynamics of adult neurogenesis" at the 17th International Neuroscience Winter Conference (host; Dr. S. Schwarzarcher), Solden, Switzerland.
    • Lucassen, P. J. (invited speaker) (4-3-2015). Hippocampal plasticity in relation to early stress, nutrition and depression., Invited lecture at the Department of Anatomy, ETH (hosts; Dr I Amrein, M Van Dijk, Zurich, Switzerland.
    • Lucassen, P. J. (invited speaker) (4-3-2015). Structural plasticity in relation to (early) stress, depression and dementia., Invited lecture at the Department of Fundamental Neurosciences, University of Lausanne (host; Dr. N. Toni), Lausanne, Switzerland.
    • Lucassen, P. J. (invited speaker) (17-2-2015). Plasticity in relation to stress and neurogenesis., Invited lecture at the King's College London, Host; Dr Sandrine Thuret, London, United Kingdom.
    • Lucassen, P. J. (invited speaker) (16-2-2015). Effects of early life stress and nutrition on adult hippocampal plasticity and function., Invited lecture at the MRCSocial, Genetic and Developmental Psychiatry Centre (host; Dr Geoff Bird), Institute of Psychiatry, King's College, London, United Kingdom.
    • Lucassen, P. J. (invited speaker) (28-1-2015). Trends in Alzheimer's disease research, a personal perspective., Invited lecture at the ISAO Meet and Greet meeting, Utrecht, The Netherlands.
    • Lucassen, P. J. (invited speaker) (15-1-2015). Structural plasticity in relation to (early) stress, nutrition and depression., Invited lecture at the department of Klinische NeuroAnatomie, Goethe Universitat, Host Dr. S. Schwarzacher, Frankfurt am Main, Germany.
    • Lucassen, P. J. (invited speaker) (15-12-2014). Alzheimer onderzoek, de stand van zaken, Invited lecture at the Board of Advisors meeting of the Internationale Stichting Alzheimer Onderzoek ISAO, Breda, The Netherlands.
    • Lucassen, P. J. (invited speaker) (6-11-2014). Addressing pressing neurobiological questions using postmortem human brain tissue, Invited lecture at Netherlands Brain Bank Psychiatry consortium meeting, NIN Amsterdam, Amsterdam, The Netherlands.
    • Lucassen, P. J. (invited speaker) (6-10-2014). State of the affairs in Alzheimer research, Invited lecture at the ISAO board meeting, Utrecht, The Netherlands.
    • Lucassen, P. J. (invited speaker) (19-9-2014). Changes in neurogenesis in relation to ritalin, fluoxetine and the 1.28 ppm MRS peak., Invited lecture at PRIOMED meeting, Rome, Italy.
    • Lucassen, P. J. (invited speaker) (7-9-2014). Food and stress effects during brain development., Invited lecture at the Route28 meeting, Chiemsee, Germany.
    • Lucassen, P. J. (invited speaker) (16-6-2014). Brain Development., Opening lecture at the Summer School on 'Early life; genes and brain development UvA/IIS, Amsterdam, The Netherlands.
    • Lucassen, P. J. (invited speaker) (14-6-2014). Plasticity changes in the brain following stress., Invited lecture Dutch Biomedical Student Conference; BIC Lecture, UMC Utrecht, Utrecht, The Netherlands.
    • Lucassen, P. J. (invited speaker) (10-6-2014). Alzheimer research, stam cells, exercise and vaccination., Invited lectureat the Alzheimer Cafe Voorburg, Voorburg, The Netherlands.
    • Lucassen, P. J. (invited speaker) (21-5-2014). Neurogenesis in the live human brain; possibilities for detection by Magnetic Resonance Spectroscopy., Invited lecture at the Netherlands Cancer Institute, Amsterdam, The Netherlands.
    • Lucassen, P. J. (invited speaker) (30-4-2014). Plasticity changes in relation to early nutrition, exercise and Alzheimer's disease., Invited lecture Dept Anatomy, University of Munich, Munich, Germany.
    • Lucassen, P. J. (invited speaker) (30-4-2014). Plasticity changes in relation to (early life) stress, nutrition and depression., Invited lecture for the Department of Molecular Neurology of the University Hospital Erlangen, Erlangen, Germany.
    • Lucassen, P. J. (invited speaker) (29-4-2014). Doublecortin and doublecortin-like as important players in early cortical development., Invited 'GrassRoot' lecture at the University of Erlangen; Host; Prof.Dr. J Winkler., Erlangen, Germany.
    • Lucassen, P. J. (invited speaker) (10-2-2014). Structural plasticity in relation to (early life) stress, nutrition and depression., Invited lecture at the 5th Brain Behav Society "Good stress, bad stress and very bad stress", Haifa, Israel.
    • Lucassen, P. J. (invited speaker) (22-1-2014). Effects of early stress and food on adult hippocampal plasticity and function., Invited Lecture at at the Netherlands Institute for the Advancement of Social and Humanities Science (NIAS), Wassenaar, The Netherlands.
    • Lucassen, P. J. (invited speaker) (16-12-2013). Plasticity changes in relation to early life stress and depression., Invited lecture at the Instututo Superior de Sanita, Rome, Rome, Italy.
    • Lucassen, P. J. (invited speaker) (18-11-2013). Plasticity changes in relation to early stress, depression and dementia., Invited Lecture at ETH Swiss Institute for Brain Research, Zurich, Host; Prof.Dr. Isabelle Mansuy, Zurich, Switzerland.
    • Lucassen, P. J. (invited speaker) (22-9-2013). Introductory lecture for the movie "Vergiss mich nicht"., Introductory lecture for the movie "Vergiss mich nicht" on the occasion of World Alzheimer day, Ketelhuis Cinema, Amsterdam, Amsterdam, The Netherlands.
    • Lucassen, P. J. (invited speaker) (17-9-2013). Structural plasticity in relation to early life stress., invited lecture at at the PRIOMED meeting, Amsterdam, The Netherlands.
    • Lucassen, P. J. (invited speaker) (4-9-2013). Structural plasticity in the adult brain in relation to (early) stress and disease., invited lecture at the VUMC Amsterdam, host Dr M. Huizinga, Amsterdam, The Netherlands.
    • Lucassen, P. J. (invited speaker) (26-6-2013). Structural and functional plasticity in relation to early stress and Alzheimer's disease., invited lecture at the EUROGENESIS meeting in Bordeaux, Bordeaux, France.
    • Lucassen, P. J. (invited speaker) (28-2-2013). Nieuwe cellen van, en voor, het oude brein., invited lectureSPUI 25, Amsterdam, The Netherlands.
    • Lucassen, P. J. (invited speaker) (21-11-2012). Neurobiological insight in Alzheimer's disease; one step forward, two steps back., invited lecture at the University Groningen, Groningen, The Netherlands.
    • Lucassen, P. J. (invited speaker) (24-10-2012). Lasting effects of early and later stress on structural plasticity., invited talk at the EUROGENESIS meeting, Paris, France.
    • Lucassen, P. J. (invited speaker) (14-10-2012). Neurogenesis, major depression and antidepressants; a relevant link?, invited lecture at the Brainstorming session, ECNP meeting, Wien, Austria.
    • Lucassen, P. J. (invited speaker) (2-10-2012). Nieuwe cellen voor het oudere brein; effecten van stress en sport, invited public lecture Alzheimer Meeting, Wijchen, The Netherlands.
    • Lucassen, P. J. (invited speaker) (18-9-2012). Structural and functional plasticity in relation to Alzheimer's disease., invited lecture at the Fall Global Discovery Meeting at Johnson&Johnson, Beersum, Belgium.
    • Lucassen, P. J. (invited speaker) (13-7-2012). Structural plasticity in relation to early life stress., invited lecture at the EBBS satelite "Stress and our social lives", Barcelona, Spain.
    • Lucassen, P. J. (invited speaker) (4-7-2012). Effects of early stress and food on adult hippocampal plasticity and function., invited lecture at the Danone Nutricials, Ede, The Netherlands.
    • Lucassen, P. J. (invited speaker) (22-6-2012). Structural plasticity changes in relation to early stress or psychoactive drug treatment., invited lecture at the European PRIOMED meeting, Caen, France.
    • Lucassen, P. J. (invited speaker) (7-5-2012). Animal models for Alzheimer's disease; where have we come from and are we there yet ?, invited lecture at the Neurodegeneration ONWA meeting, Amsterdam, The Netherlands.
    • Lucassen, P. J. (invited speaker) (19-4-2012). Structural plasticity in relation to stress, age, dementia and depression, invited lecture at the EURON Neuroscience Meeting, Braha, Portugal.
    • Lucassen, P. J. (invited speaker) (19-4-2012). Structural plasticity in relation to stress, age, dementia and depression, invited lecture at the EURON Neuroscience Meeting, Braha, Portugal.
    • Lucassen, P. J. (invited speaker) (9-3-2012). Neurogenesis in depression?, invited lecture at the International Conference Controverses in Neuroscience CONY, Wien, Austria.
    • Lucassen, P. J. (invited speaker) (25-2-2012). Adult neurogenesis, stress and depression, invited lecture at the Karolinska Institute, Stockholm, Sweden.
    • Lucassen, P. J. (invited speaker) (6-2-2012). New neurons in old brains., invited lecture at the Faculty Colloquiem Universiteit van Amsterdam, Amsterdam, The Netherlands.
    • Lucassen, P. J. (invited speaker) (31-1-2012). Early stress and neurogenesis, invited lecture at the University Maastricht, Maastricht, The Netherlands.
    • Lucassen, P. J. (invited speaker) (28-1-2012). Adult structural plasticity in relation to stress, depression and dementia, invited lecture at Eurogenesis meeting, Les Diablerets, Switzerland.
    • Lucassen, P. J. (speaker) (11-11-2010). Mouse models for Alzheimer; where have we come from and are we there yet?, Invited Lecture at the ISAO workshop., San Diego, USA.
    • Lucassen, P. J. (speaker) (10-11-2010). "Alzheimer's disease 2011; the state of affairs"., Plenary introductory lecture for the ISAO Alzheimer workshop, San Dïego, USA.
    • Lucassen, P. J. (speaker) (14-10-2010). Stress and new brain cells., Invited Lecture at the Dutch Publieksdag of the Dutch Brain Foundation., Utrecht, The Netherlands.
    • Lucassen, P. J. (speaker) (30-9-2010). Neurogenesis in Alzheimer (models), Invited Lecture at the INSERM Neurogenesis Meeting, Bordeaux, France.
    • Lucassen, P. J. (speaker) (31-8-2010). Alzheimer’s disease: neurogenesis and enriched environment; promising avenues?, Lecture at the ECNP Brain stoming session, Amsterdam, The Netherlands.
    • Lucassen, P. J. (speaker) (20-5-2010). Structural plasticity in relation to (early) stress and depression., Invited lecture at the Institute for Neuroscience and Academic Psychiatry, Medical School, New Castle, U.K.
    • Lucassen, P. J. (speaker) (15-3-2010). Structural plasticity in dementia., Lecture at the International NEURAD meeting, Amsterdam, the Netherlands.
    • Lucassen, P. J. (speaker) (25-1-2010). Stem cells in the adult brain., invited lecture Graduate School BCN, Groningen, The Netherlands.
    • Lucassen, P. J. (speaker) (2-12-2009). Structural plasticity in dementia (models)., NEURAD Meeting, Leuven, Belgium.
    • Lucassen, P. J. (speaker) (29-7-2009). Structural plasticity and neurogenesis in relation to stress and depression., The British Association for Psychopharmacology Meeting, Oxford, UK.
    • Lucassen, P. J. (speaker) (5-6-2009). Doublecortin-like proteins during development and in developmental pathologies., ENP Meeting, Doorwerth, the Netherlands.
    • Lucassen, P. J. (speaker) (4-6-2009). Changes in neurogenesis in Alzheimer (models)., EndoNeuroPsycho ENP Meeting, Doorwerth, the Netherlands.
    • Lucassen, P. J. (speaker) (26-1-2009). Neurogenesis in relation to Alzheimer’s disease and mouse models for dementia., Winterschool on Neuroscience, Colorado, USA.
    • Lucassen, P. J. (speaker) (22-1-2009). Neurogenesis, stress and depression., Winter Conference on Neuroscience, Virgin Islands, USA.
    • Lucassen, P. J. (speaker) (12-1-2009). Stem cells in the adult brain., Graduate School BCN, Groningen, the Netherlands.
    • Lucassen, P. J. (speaker) (3-12-2008). Expression of doublecortin and doublecortin-like during early cortical development and in human brain., NCMLS, University of Nijmegen, Nijmegen, The Netherlands.
    • Lucassen, P. J. (speaker) (13-11-2008). Update on Alzheimer’s disease, EURON PhD Workshop on “Animal models to mimic and understand Alzheimer’s disease etiology” at the Society for Neuroscience premeeting, Washington, USA.
    • Lucassen, P. J. (speaker) (18-9-2008). Structural plasticity during early development and in the Alzheimer brain, 2nd NEURAD Summer School, Leuven, Belgium.
    • Lucassen, P. J. (speaker) (1-9-2008). Neurogenesis in relation to aging and dementia, ECNP Meeting, Barcelona, Spain.
    • Lucassen, P. J. (speaker) (5-6-2008). Doublecortin proteins in human brain, EndoNeuroPsycho Meeting, Doorwerth, The Netherlands.
    • Lucassen, P. J. (speaker) (21-5-2008). Voor- en nadelen van een demente muis, ISAO Meeting, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.
    • Lucassen, P. J. (speaker) (21-4-2008). Alzheimer Mouse models; where have we come from and are we there yet ?, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.
    • Lucassen, P. J. (speaker) (14-4-2008). Neurogenesis in relation to dementia, Bilateral Paris-Amsterdam NEURAD Meeting, Paris, France.
    • Lucassen, P. J. (speaker) (3-4-2008). Zit stress tussen de oren ?, lezing bij het proefstuderen, Amsterdam, the Netherlands.
    • Lucassen, P. J. (speaker) (28-3-2008). Structural hippocampal plasticity in relation to dementia, Bilateral Amsterdam-Gottingen NEURAD meeting, Dept Psychiatry, Gottingen University, Gottingen, Germany.
    • Lucassen, P. J. (speaker) (14-3-2008). "Effects of perinatal stress exposure on behaviour, endocrinology and adult neurogenesis in 2 rat lines that differ in stress coping style and anxiety related behaviour, VW Statussymposium, Tubingen, Germany.
    • Lucassen, P. J. (speaker) (10-3-2008). Nieuwe ontwikkelingen in het hersenonderzoek naar stress en stam cellen, the Dutch Brain Awareness week at the Jac.P. Thijsse college, Castricum, the Netherlands.
    • Lucassen, P. J. (speaker) (29-2-2008). Can we determine neurogenesis in the human brain, Stem cell meeting at the Netherland Institute for Neuroscience, Amsterdam, the Netherlands.
    • Lucassen, P. J. (speaker) (22-2-2008). Neurogenesis in relation to stress, depression and dementia, Amsterdam-Groningen bilateral meeting, Amsterdam, The Netherlands.
    • Lucassen, P. J. (speaker) (22-1-2008). Neurogenesis, Stress and Depression, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
    • Lucassen, P. J. (speaker) (21-1-2008). Neurogenesis and hippocampal function in Alzheimer’s disease, Wuhan Institute for Neuroscience and Neuroengineering (WINN), South-center University for Nationalities, Wuhan, China.
    • Lucassen, P. J. (speaker) (4-12-2007). Cellular plasticity changes in relation to stress and dementia., Invited Lecture at the Department of Psychiatry, Gottingen University, host: Prof.Dr. T. Bayer, Gottingen in Duitsland.
    • Lucassen, P. J. (speaker) (28-11-2007). Structural plasticity and neurogenesis in relation to stress and depression., Emile Kraepelin Professorship to Marian Joels bij het Max Planck Inst. for Psychiatry, Munchen, Duitsland.
    • Lucassen, P. J. (speaker) (10-10-2007). The role of neurogenesis in antidepressant action., invited discussant at the Targeted Expert Meeting preceding the ECNP stress meeting, Wenen Oostenrijkk.
    • Lucassen, P. J. (speaker) (10-10-2007). Neurogenesis in neuropsychiatric disorders., Invited lecture at the Targeted Expert Meeting prior to the ECNP meeting in Vienna, Wenen, Oostenrijk.
    • Lucassen, P. J. (speaker) (21-9-2007). Regulation of cellular plasticity by stress and dementia., 1st NEURAD summer school, Gottingen, Duitsland.
    • Lucassen, P. J. (speaker) (4-6-2007). Changes in neurogenesis in dementia; are they functionally relevant?, BCN International Stem cell symposium, Groningen.
    • Lucassen, P. J. (speaker) (21-5-2007). Increases in LTP and learning but not neurogenesis in young P301L tau mutant mice., Talk at the symposium "Modeling neuro-degeneration: causes and consequences", of the 9th Annual Genes, Brain and Behavior Meeting - IBANGS 2007, Doorwerth.
    • Lucassen, P. J. (speaker) (14-5-2007). Alzheimer mouse models; where have come from and are we there yet?, Meeting: the Internationale Stichting Alzheimer Onderzoek in Bad Honnef, Bonn, Duitsland.
    • Lucassen, P. J. (speaker) (2-4-2007). Does depression damage the brain?, Conference on Depression: Causes in the Brain, Consequences on the Body. Organized by the Institute of Psychiatry, King's College London, Royal Society of Medicine, London Engeland.
    • Lucassen, P. J. (speaker) (12-1-2007). Changes in neurogenesis in relation to dementia., NEURAD Kick off symposium, Berlijn Duitsland.
    • Lucassen, P. J. (speaker) (1-11-2006). Changes in neurogenesis and hippocampal function in tau transgenic mice, lezing geven op uitnodiging van Dr. Kempermann bij het Max-Delbrück-Centrum für Molekulare Medizin (MDC) Berlin-Buch, Germany, Berlijn, Duitsland.
    • Lucassen, P. J. (speaker) (1-11-2006). Doublecortin-like; a microtubule associated protein involved in mitotic spindle and radial fiber stability of radial glia cells during early cortical development., Invited lecture at the Max Delbruck Centre for Molecular MedicineDr. G. Kempermann, Berlin Duitsland.
    • Lucassen, P. J. (speaker) (1-11-2006). Structural plasticity in the adult brain in relation to stress and disease., lezing geven op uitnodiging van Prof. Heuser bij de Klinik und Hochschulambulanz für Psychiatrie und Psychotherapie, Charite Campus Benjamin Franklin, University Berlin, Berlijn, Duitsland.
    • Lucassen, P. J. (speaker) (11-10-2006). Doublecortin-like; a novel microtubule associated protein involved in mitotic spindle and radial fiber stability., lezing bij Stem Cell Cluster Groningen, Groningen University, Groningen.
    • Lucassen, P. J. (speaker) (29-9-2006). Structural plasticity in the adult brain in relation to stress and disease., lezing bij Department of Molecular Neurobiology University of Groningen, Groningen.
    • Lucassen, P. J. (speaker) (27-9-2006). Increases in LTP and learning but not neurogenesis in young P301L tau mutant mice, ISPNE meeting, Leiden.
    • Lucassen, P. J. (speaker) (4-9-2006). Structural plasticity and adult neurogenesis in relation to stress and dementia., the Route 28 Summit in Neurobiology, Chiemfrausee, Duitsland.
    • Lucassen, P. J. (speaker) (9-7-2006). Structural hippocampal plasticity in relation to stress and depression", FENS meeting, Wenen Oostenrijk.
    • Lucassen, P. J. (speaker) (26-6-2006). Structural plasticity in relation to stress and depression., lezing bij The University of Bristol, United Kingdom, Bristol Engeland.
    • Lucassen, P. J. (speaker) (19-5-2006). Doublecortin-like, a novel microtubule associated protein expressed in radial glia is crucial for neuronal precursor division and radial process stability during early corticogenesis, Neuronal Developmental Disorders meeting, Doorwerth.
    • Lucassen, P. J. (speaker) (20-1-2006). Alzheimer’s disease; the state-of-affairs., NIBI meeting on The Biology of Memory, Lunteren.
    • Lucassen, P. J. (speaker) (16-1-2006). Neurogenesis and stem cells in the adult brain., lezing bij Department of Medical Physiology, University Medical Centre Groningen, Groningen.
    • Lucassen, P. J. (speaker) (26-9-2005). Changes in neurogenesis, LTP and memory function in tau transgenic mice, symposium celebrating 10 years of AFI / ISAO, Frankfurt.
    • Lucassen, P. J. (speaker) (16-9-2005). Structural dynamic plasticity in the hippocampus in relation to stress and depression, Psychopharmacology, Utrecht.
    • Lucassen, P. J. (speaker) (14-6-2005). Changes in neurogenesis, LTP and memory function in tau transgenic mice, Netherlands Institute for Brain Research, Amsterdam.
    • Lucassen, P. J. (speaker) (7-6-2005). Stress and hippocampal structural plasticity; possible mechanisms, INSERM U.588, Institut François Magendie, Bordeaux.
    • Lucassen, P. J. (speaker) (29-3-2005). A novel Doublecortin-Like Protein, Expressed in Radial Glia of the Early Neocortex is Critical for Mitotic Spindle Stability of Neural Precursors, Rudolf Magnus Institute for Neuroscience, University of Utrecht, Utrecht.
    • Lucassen, P. J. (speaker) (18-2-2005). Live and let die: neurogenesis and apoptosis in the stressed and depressed brain, 6th International Meeting of the German Neuroscience Society, 30th Göttingen Neurobiology Conference, Göttingen.
    • Lucassen, P. J. (speaker) (22-11-2004). Structural dynamic changes in the hippocampus in relation to stress and depression., invited lecture at the Dep. Cellular Animal Physiology of the Radboud University, Nijmegen (Hosts: Dr. Tamas Kozicz, Prof.Dr. E. Roubos), Nijmegen.
    • Lucassen, P. J. (speaker) (23-9-2004). Adult neurogenesis in relation to stress and depression, Invited Lecture at the FOS Master Course 2004 in Leiden (host; Dr E. Vreugdenhil), Leiden.
    • Lucassen, P. J. (speaker) (3-9-2004). Structural dynamic changes in the hippocampus of tau mice; consequences for function ?, Invited Lecture at the Department of Psychiatry and Neuropsychology, University of Maastricht (Hosts: Dr. C. Schmitz and Prof.Dr. H.W. Steinbusch), Maastricht.
    • Lucassen, P. J. (speaker) (31-8-2004). Functional roles of neurogenesis in the adult brain, Genomics for Our World" Program; Workshop on Neurogenesis & Neurogenomics, organized by the UK/Dutch Ambassy, Rotterdam.
    • Lucassen, P. J. (speaker) (3-6-2004). Structural plasticity changes in major depression, lezing bij de sessie Adult neurogenesis and depression bij de EndoNeuroPsycho vergadering, Doorwerth.
    • Lucassen, P. J. (speaker) (22-4-2004). New neurons in the adult brain; a possible role in learning ?, lezing bij de vereniging Studenten Psychologie Amsterdam VSPA lecture, Amsterdam.
    • Lucassen, P. J. (speaker) (13-12-2003). Adult neurogenesis and apoptosis, FENS Winterschool 2003, Kitzbuhel.
    • Lucassen, P. J. (speaker) (17-11-2003). Adult neurogenesis in relation to stress and depression, FOS symposium, Leiden.
    • Lucassen, P. J. (speaker) (10-9-2003). Glucocorticoid receptor beta expression in the human hippocampus, NIBR, Amsterdam.
    • Lucassen, P. J. (speaker) & Neumann, I. (speaker) (7-9-2003). Effects of pre- and postnatal environmental factors on cognitive function, hippocampal neurogenesis and emotionality; vulnerability to early life events., the 2nd Symposium of the Volkswagen Stiftung, Magdeburg.
    • Lucassen, P. J. (speaker) (16-12-2002). Hippocampal neurogenesis in the adult brain: a function in learning processes, Neurofederation Automn Symposium, Amsterdam.
    • Lucassen, P. J. (speaker) (13-11-2002). New cells in adult brains; a role in Alzheimer, International Stichting Alzheimar Onderzoek (ISAO), Rotterdam.
    • Lucassen, P. J. (speaker) (22-10-2002). Adult neurogenesis and apoptosis in relation to early steroid exposure, stress and ageing, VW Stiftung symposium, Regensburg, Germany.
    • Lucassen, P. J. (speaker) (26-9-2002). Stem cells in the adult brain; a functional role in learning?, Learning Processes Conference, Haren.
    • Lucassen, P. J. (speaker) (21-5-2002). Adult neurogenisis and apoptosis in the hippocampus in relation to age, stress and disease, Centre Human Genetics, Leuven, Belgium.
    • Lucassen, P. J. (speaker) (11-5-2002). Stem cells in the adult brain; (im)possibilities and applications, Ataxia Patients Society, Bunnik.
    • Lucassen, P. J. (speaker) (8-5-2002). Apoptosis and Neurogenesis in the hippocampus, Elba Summer School, Italy.
    • Lucassen, P. J. (speaker) (9-4-2002). Neurogenesis and apoptosis in the hippocampus, Capita Selecta, Leiden.
    • Lucassen, P. J. (speaker) (30-1-2002). An overview and update on adult neurogenesis, Biological Centre, Haren.
    • Lucassen, P. J. (speaker) (24-1-2002). Stem cells in the adult mammalian CNS, changes with aging and possible functional applications, EURON Winter school, Kerkrade.
    • Lucassen, P. J. (speaker) (18-10-2001). New cells in old brains, Nationale Publieksdag Hersenonderzoek, Utrecht, The Netherlands.
    • Lucassen, P. J. (speaker) (27-4-2001). Hippocampal apoptosis in major depression, Master Class SPINOZA chair to Prof.Dr.Dr. F. Holsboer, Amsterdam, The Netherlands.
    • Lucassen, P. J. (speaker) (25-1-2001). Young and old cells in young and old brains: changes in hippocampal apoptosis and neurogenesis with aging, Hungarian Neuroscience Society Conference, Szeged, Hungary.

    Andere

    • Lucassen, P. J. (participant) (10-2018). 31st ECNP Congress - Barcelona 2018, Barcelona, Spain. sessions organized and chaired by Paul Lucassen on 'New advances in the therapy of Huntington’s and Parkinson’s disease’. (participating in a conference, workshop, ...).
    • Lucassen, P. J. (other) (1-1-2016). a novel Erasmus training program with University Athens (other).

    2019

    2018

    2016

    2015

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