Dr. J.D. (Joram) Mul
Faculteit der Natuurwetenschappen, Wiskunde en Informatica
Swammerdam Institute for Life Sciences
Bezoekadres
- Science Park 904
- Kamernummer: C3.268
Postadres
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Postbus 94246
1090 GE Amsterdam
Contactgegevens
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Publicaties
2025
Shiba, A., Hardonk, M. H., Foppen, E., Kool, T., la Fleur, S. E., Lucassen, P. J., Yi, C. X., Stenvers, D. J., Mul, J. D., & Kalsbeek, A. (2025). Voluntary Running and Estrous Cycle Modulate ΔFOSB in the Suprachiasmatic Nucleus of the Wistar Rat. Journal of Circadian Rhythms, 23, Article 7. https://doi.org/10.5334/jcr.257
2024
- Caruso, M. G., Nicolas, S., Lucassen, P. J., Mul, J. D., O'Leary, O. F., & Nolan, Y. M. (2024). Ageing, Cognitive Decline, and Effects of Physical Exercise: Complexities, and Considerations from Animal Models. Brain Plasticity, 9(1-2), 43-73. https://doi.org/10.3233/BPL-230157 [details]
- Shiba, A., de Goede, P., Tandari, R., Foppen, E., Korpel, N. L., Coopmans, T. V., Hellings, T. P., Jansen, M. W., Ruitenberg, A., Ritsema, W. I. G. R., Yi, C.-X., Mul, J. D., Stenvers, D. J., & Kalsbeek, A. (2024). Synergy between time-restricted feeding and time-restricted running is necessary to shift the muscle clock in male wistar rats. Neurobiology of Sleep and Circadian Rhythms, 17, Article 100106. https://doi.org/10.1016/j.nbscr.2024.100106 [details]
2023
- Shemery, A. M., Zendlo, M., Kowalski, J., Gorrell, E., Everett, S., Wagner, J. G., Davis, A. E., Koch, L. G., Britton, S. L., Mul, J. D., & Novak, C. M. (2023). Reduced contextually induced muscle thermogenesis in rats with calorie restriction and lower aerobic fitness but not monogenic obesity. Temperature (Austin, Tex.), 10(3), 379-393. https://doi.org/10.1080/23328940.2023.2171669 [details]
- Slomp, M., de Lange, I. G. S., Mul, J. D., Schrantee, A., & la Fleur, S. E. (2023). Investigating Habenula Functional Connectivity and Reward-Related Activity in Obesity Using Human Connectome Project Data. Brain Connectivity, 13(9), 541-552. https://doi.org/10.1089/brain.2023.0034 [details]
- Ugur, M., Pieterse, I., Meerhoff, G. F., Eggels, L., Lamuadni, K., Unmehopa, U. A., Booij, J., la Fleur, S. E., & Mul, J. D. (2023). Voluntary physical activity modulates self-selection of a high-caloric choice diet in male Wistar rats. Physiology & behavior, 268, Article 114239. https://doi.org/10.1016/j.physbeh.2023.114239 [details]
2022
- Gumbs, M. C. R., Eggels, L., Vuuregge, A. H., Unmehopa, U. A., Mul, J. D., & la Fleur, S. E. (2022). Effects of Neuropeptide Y administration into the lateral hypothalamus on intake of free-choice high-fat high-sucrose diet components of the male Wistar rat. Nutritional Neuroscience, 25(3), 621-630. https://doi.org/10.1080/1028415X.2020.1788774
2021
- Homberg, J. R., Adan, R. A. H., Alenina, N., Asiminas, A., Bader, M., Beckers, T., Begg, D. P., Blokland, A., Burger, M. E., van Dijk, G., Eisel, U. L. M., Elgersma, Y., Englitz, B., Fernandez-Ruiz, A., Fitzsimons, C. P., van Dam, A.-M., Gass, P., Grandjean, J., Havekes, R., ... Genzel, L. (2021). The continued need for animals to advance brain research. Neuron, 109(15), 2374-2379. https://doi.org/10.1016/j.neuron.2021.07.015 [details]
- Joshi, A., Kool, T., Diepenbroek, C., Koekkoek, L. L., Eggels, L., Kalsbeek, A., Mul, J. D., Barrot, M., & la Fleur, S. E. (2021). Dopamine D1 receptor signalling in the lateral shell of the nucleus accumbens controls dietary fat intake in male rats. Appetite, 167, Article 105597. https://doi.org/10.1016/j.appet.2021.105597 [details]
- Koert, A., Ploeger, A., Bockting, C. L. H., Schmidt, M. V., Lucassen, P. J., Schrantee, A., & Mul, J. D. (2021). The social instability stress paradigm in rat and mouse: A systematic review of protocols, limitations, and recommendations. Neurobiology of Stress, 15, Article 100410. https://doi.org/10.1016/j.ynstr.2021.100410 [details]
2020
- Genzel, L., Adan, R., Berns, A., van den Beucken, J. J. J. P., Blokland, A., Boddeke, E. H. W. G. M., Bogers, W. M., Bontrop, R., Bulthuis, R., Bousema, T., Clevers, H., Coenen, T. C. J. J., van Dam, A-M., Deen, P. M. T., van Dijk, K. W., Eggen, B. J. L., Elgersma, Y., Erdogan, I., Englitz, B., ... Homberg, J. R. (2020). How the COVID-19 pandemic highlights the necessity of animal research: correction. Current Biology, 30(21), 4328. https://doi.org/10.1016/j.cub.2020.10.033
- Genzel, L., Adan, R., Berns, A., van den Beucken, J. J. J. P., Blokland, A., Boddeke, E. H. W. G. M., Bogers, W. M., Bontrop, R., Bulthuis, R., Bousema, T., Clevers, H., Coenen, T. C. J. J., van Dam, A.-M., Deen, P. M. T., van Dijk, K. W., Eggen, B. J. L., Elgersma, Y., Erdogan, I., Englitz, B., ... Homberg, J. R. (2020). How the COVID-19 pandemic highlights the necessity of animal research. Current Biology, 30(18), R1014-R1018. https://doi.org/10.1016/j.cub.2020.08.030 [details]
- Gumbs, M. C. R., Eggels, L., Kool, T., Unmehopa, U. A., van den Heuvel, J. K., Lamuadni, K., Mul, J. D., & la Fleur, S. E. (2020). Neuropeptide Y Signaling in the Lateral Hypothalamus Modulates Diet Component Selection and is Dysregulated in a Model of Diet-Induced Obesity. Neuroscience, 447, 28-40. https://doi.org/10.1016/j.neuroscience.2019.12.014 [details]
- Koekkoek, L. L., Unmehopa, U. A., Eggels, L., Kool, T., Lamuadni, K., Diepenbroek, C., Mul, J. D., Serlie, M. J., & la Fleur, S. E. (2020). A free-choice high-fat diet modulates the effects of a sucrose bolus on the expression of genes involved in glucose handling in the hypothalamus and nucleus accumbens. Physiology & behavior, 222, Article 112936. https://doi.org/10.1016/j.physbeh.2020.112936 [details]
- Zheng, J., Alves-Wagner, A. B., Stanford, K. I., Prince, N. B., So, K., Mul, J. D., Dirice, E., Hirshman, M. F., Kulkarni, R. N., & Goodyear, L. J. (2020). Maternal and paternal exercise regulate offspring metabolic health and beta cell phenotype. BMJ Open Diabetes Research and Care, 8(1), Article e000890. https://doi.org/10.1136/bmjdrc-2019-000890
2019
- Chaffin, A. T. B., Fang, Y., Larson, K. R., Mul, J. D., & Ryan, K. K. (2019). Sex-dependent effects of MC4R genotype on HPA axis tone: implications for stress-associated cardiometabolic disease. Stress, 22(5), 571-580. https://doi.org/10.1080/10253890.2019.1610742
- Gumbs, M. C. R., Vuuregge, A. H., Eggels, L., Unmehopa, U. A., Lamuadni, K., Mul, J. D., & la Fleur, S. E. (2019). Afferent neuropeptide Y projections to the ventral tegmental area in normal-weight male Wistar rats. Journal of Comparative Neurology, 527(16), 2659-2674. https://doi.org/10.1002/cne.24698
- Slomp, M., Belegri, E., Blancas-Velazquez, A. S., Diepenbroek, C., Eggels, L., Gumbs, M. C. R., Joshi, A., Koekkoek, L. L., Lamuadni, K., Ugur, M., Unmehopa, U. A., la Fleur, S. E., & Mul, J. D. (2019). Stressing the importance of choice: Validity of a preclinical free-choice high-caloric diet paradigm to model behavioural, physiological and molecular adaptations during human diet-induced obesity and metabolic dysfunction. Journal of Neuroendocrinology, 31(5), Article e12718. https://doi.org/10.1111/jne.12718
- Takahashi, H., Alves, C. R. R., Stanford, K. I., Middelbeek, R. J. W., Nigro, P., Ryan, R. E., Xue, R., Sakaguchi, M., Lynes, M. D., So, K., Mul, J. D., Lee, M. Y., Balan, E., Pan, H., Dreyfuss, J. M., Hirshman, M. F., Azhar, M., Hannukainen, J. C., Nuutila, P., ... Goodyear, L. J. (2019). TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism. Nature Metabolism, 1(2), 291-303. https://doi.org/10.1038/s42255-018-0030-7
2018
- Belegri, E., Eggels, L., Unmehopa, U. A., Mul, J. D., Boelen, A., & la Fleur, S. E. (2018). The effects of overnight nutrient intake on hypothalamic inflammation in a free-choice diet-induced obesity rat model. Appetite, 120, 527-535. https://doi.org/10.1016/j.appet.2017.10.006
- Mul, J. D. (2018). Voluntary exercise and depression-like behavior in rodents: Are we running in the right direction? Journal of molecular endocrinology, 60(3), R77-R95. https://doi.org/10.1530/JME-17-0165
- Mul, J. D., Soto, M., Cahill, M. E., Ryan, R. E., Takahashi, H., So, K., Zheng, J., Croote, D. E., Hirshman, M. F., La Fleur, S. E., Nestler, E. J., & Goodyear, L. J. (2018). Voluntary wheel running promotes resilience to chronic social defeat stress in mice: A role for nucleus accumbens ΔfosB. Neuropsychopharmacology, 43(9), 1934-1942. https://doi.org/10.1038/s41386-018-0103-z
2017
- Koekkoek, L. L., Mul, J. D., & la Fleur, S. E. (2017). Glucose-sensing in the reward system. Frontiers in Neuroscience, 11, Article 716. https://doi.org/10.3389/fnins.2017.00716
2016
- Mul, J. D., & La Fleur, S. E. (2016). Nutritional and behavioral regulators of choice behavior. Current Opinion in Behavioral Sciences, 9, 61-65. https://doi.org/10.1016/j.cobeha.2016.01.009
- Mul, J. D., Zheng, J., & Goodyear, L. J. (2016). Validity assessment of 5 day repeated forced-swim stress to model human depression in young-adult C57BL/6J and BALB/CJ mice. eNeuro, 3(6), Article e0201. https://doi.org/10.1523/ENEURO.0201-16.2016
- Zheng, J., Zhang, Q., Mul, J. D., Yu, M., Xu, J., Qi, C., Wang, T., & Xiao, X. (2016). Maternal high-calorie diet is associated with altered hepatic microRNA expression and impaired metabolic health in offspring at weaning age. Endocrine, 54(1), 70-80. https://doi.org/10.1007/s12020-016-0959-9
2015
- Begg, D. P., May, A. A., Mul, J. D., Liu, M., D'Alessio, D. A., Seeley, R. J., & Woods, S. C. (2015). InsulinDetemir is transported fromblood to cerebrospinal fluid and has prolonged central anorectic action relative to NPH Insulin. Diabetes, 64(7), 2457-2466. https://doi.org/10.2337/db14-1364
- Mul, J. D., Stanford, K. I., Hirshman, M. F., & Goodyear, L. J. (2015). Exercise and Regulation of Carbohydrate Metabolism. In C. Bouchard (Ed.), Molecular and Cellular Regulation of Adaptation to Exercise, 2015 (pp. 17-37). (Progress in Molecular Biology and Translational Science; Vol. 135). Elsevier B.V. https://doi.org/10.1016/bs.pmbts.2015.07.020
- Obici, S., Magrisso, I. J., Ghazarian, A. S., Shirazian, A., Miller, J. R., Loyd, C. M., Begg, D. P., Krawczewski Carhuatanta, K. A., Haas, M. K., Davis, J. F., Woods, S. C., Sandoval, D. A., Seeley, R. J., Goodyear, L. J., Pothos, E. N., & Mul, J. D. (2015). Moderate voluntary exercise attenuates the metabolic syndrome in melanocortin-4 receptor-deficient rats showing central dopaminergic dysregulation. Molecular Metabolism, 4(10), 692-705. https://doi.org/10.1016/j.molmet.2015.07.003
- Yu, H., Fujii, N. L., Toyoda, T., An, D., Farese, R. V., Leitges, M., Hirshman, M. F., Mul, J. D., & Goodyear, L. J. (2015). Contraction stimulates muscle glucose uptake independent of atypical PKC. Physiological Reports, 3(11), Article e12565. https://doi.org/10.14814/phy2.12565
2014
- Begg, D. P., Steinbrecher, K. A., Mul, J. D., Chambers, A. P., Kohli, R., Haller, A., Cohen, M. B., Woods, S. C., & Seeley, R. J. (2014). Effect of guanylate cyclase-C activity on energy and glucose homeostasis. Diabetes, 63(11), 3798-3804. https://doi.org/10.2337/db14-0160
- Mul, J. D., Begg, D. P., Haller, A. M., Pressler, J. W., Sorrell, J., Woods, S. C., Farese, R. V., Seeley, R. J., & Sandoval, D. A. (2014). MGAT2 deficiency and vertical sleeve gastrectomy have independent metabolic effects in the mouse. American Journal of Physiology - Endocrinology and Metabolism, 307(11), E1065-E1072. https://doi.org/10.1152/ajpendo.00376.2014
- Ryan, K. K., Mul, J. D., Clemmensen, C., Egan, A. E., Begg, D. P., Halcomb, K., Seeley, R. J., Herman, J. P., & Ulrich-Lai, Y. M. (2014). Loss of melanocortin-4 receptor function attenuates HPA responses to psychological stress. Psychoneuroendocrinology, 42, 98-105. https://doi.org/10.1016/j.psyneuen.2014.01.010
2013
- Begg, D. P., Mul, J. D., Liu, M., Reedy, B. M., D'Alessio, D. A., Seeley, R. J., & Woods, S. C. (2013). Reversal of diet-induced obesity increases insulin transport into cerebrospinal fluid and restores sensitivity to the anorexic action of central insulin in male rats. Endocrinology, 154(3), 1047-1054. https://doi.org/10.1210/en.2012-1929
- Mul, J. D., & Adan, R. A. H. (2013). Melanocortins. In Handbook of Biologically Active Peptides (pp. 1135-1142). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-385095-9.00153-6
- Mul, J. D., Begg, D. P., Barrera, J. G., Li, B., Matter, E. K., D'Alessio, D. A., Woods, S. C., Seeley, R. J., & Sandoval, D. A. (2013). High-fat diet changes the temporal profile of GLP-1 receptor-mediated hypophagia in rats. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 305(1), R68-R77. https://doi.org/10.1152/ajpregu.00588.2012
- Mul, J. D., O'Duibhir, E., Shrestha, Y. B., Koppen, A., Vargoviç, P., Toonen, P. W., Zarebidaki, E., Kvetnansky, R., Kalkhoven, E., Cuppen, E., & Bartness, T. J. (2013). Pmch-Deficiency in Rats Is Associated with Normal Adipocyte Differentiation and Lower Sympathetic Adipose Drive. PLoS ONE, 8(3), Article e60214. https://doi.org/10.1371/journal.pone.0060214
- Mul, J. D., Seeley, R. J., Woods, S. C., & Begg, D. P. (2013). Angiotensin-converting enzyme inhibition reduces food intake and weight gain and improves glucose tolerance in melanocortin-4 receptor deficient female rats. Physiology and Behavior, 121, 43-48. https://doi.org/10.1016/j.physbeh.2013.01.013
- Mul, J. D., Spruijt, B. M., Brakkee, J. H., & Adan, R. A. H. (2013). Melanocortin MC4 receptor-mediated feeding and grooming in rodents. European Journal of Pharmacology, 719(1-3), 192-201. https://doi.org/10.1016/j.ejphar.2013.04.060
2012
- Davis, J. F., Schurdak, J. D., Magrisso, I. J., Mul, J. D., Grayson, B. E., Pfluger, P. T., Tschöp, M. H., Seeley, R. J., & Benoit, S. C. (2012). Gastric bypass surgery attenuates ethanol consumption in ethanol-preferring rats. Biological Psychiatry, 72(5), 354-360. https://doi.org/10.1016/j.biopsych.2012.01.035
- Mul, J. D., Begg, D. P., Alsters, S. I. M., van Haaften, G., Duran, K. J., D'Alessio, D. A., le Roux, C. W., Woods, S. C., Sandoval, D. A., Blakemore, A. I. F., Cuppen, E., van Haelst, M. M., & Seeley, R. J. (2012). Effect of Vertical sleeve gastrectomy in melanocortin receptor 4-deficient rats. American Journal of Physiology - Endocrinology and Metabolism, 303(1), E103-E110. https://doi.org/10.1152/ajpendo.00159.2012
- Mul, J. D., Van Boxtel, R., Bergen, D. J. M., Brans, M. A. D., Brakkee, J. H., Toonen, P. W., Garner, K. M., Adan, R. A. H., & Cuppen, E. (2012). Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat. Obesity, 20(3), 612-621. https://doi.org/10.1038/oby.2011.81
- Nadra, K., Médard, J. J., Mul, J. D., Han, G. S., Grès, S., Pende, M., Metzger, D., Chambon, P., Cuppen, E., Saulnier-Blache, J. S., Carman, G. M., Desvergne, B., & Chrast, R. (2012). Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue. Molecular and Cellular Biology, 32(23), 4794-4810. https://doi.org/10.1128/MCB.00512-12
2011
- Mul, J. D., Nadra, K., Jagalur, N. B., Nijman, I. J., Toonen, P. W., Médard, J. J., Grès, S., De Bruin, A., Han, G. S., Brouwers, J. F., Carman, G. M., Saulnier-Blache, J. S., Meijer, D., Chrast, R., & Cuppen, E. (2011). A hypomorphic mutation in Lpin1 induces progressively improving neuropathy and lipodystrophy in the rat. Journal of Biological Chemistry, 286(30), 26781-26793. https://doi.org/10.1074/jbc.M110.197947
- Mul, J. D., la Fleur, S. E., Toonen, P. W., Afrasiab-Middelman, A., Binnekade, R., Schetters, D., Verheij, M. M. M., Sears, R. M., Homberg, J. R., Schoffelmeer, A. N. M., Adan, R. A. H., DiLeone, R. J., de Vries, T. J., & Cuppen, E. (2011). Chronic loss of melanin-concentrating hormone affects motivational aspects of feeding in the rat. PLoS ONE, 6(5), Article e19600. https://doi.org/10.1371/journal.pone.0019600
2010
- Mul, J. D., Yi, C. X., Van Den Berg, S. A. A., Ruiter, M., Toonen, P. W., Van Der Elst, M. C. J., Voshol, P. J., Ellenbroek, B. A., Kalsbeek, A., La Fleur, S. E., & Cuppen, E. (2010). Pmch expression during early development is critical for normal energy homeostasis. American Journal of Physiology - Endocrinology and Metabolism, 298(3), E477-E488. https://doi.org/10.1152/ajpendo.00154.2009
2009
- Homberg, J. R., Mul, J. D., de Wit, E., & Cuppen, E. (2009). Complete knockout of the nociceptin/orphanin FQ receptor in the rat does not induce compensatory changes in μ, δ and κ opioid receptors. Neuroscience, 163(1), 308-315. https://doi.org/10.1016/j.neuroscience.2009.06.021
2008
- Boxem, M., Maliga, Z., Klitgord, N., Li, N., Lemmens, I., Mana, M., de Lichtervelde, L., Mul, J. D., van de Peut, D., Devos, M., Simonis, N., Yildirim, M. A., Cokol, M., Kao, H. L., de Smet, A. S., Wang, H., Schlaitz, A. L., Hao, T., Milstein, S., ... Vidal, M. (2008). A Protein Domain-Based Interactome Network for C. elegans Early Embryogenesis. Cell, 134(3), 534-545. https://doi.org/10.1016/j.cell.2008.07.009
2007
- Homberg, J. R., Olivier, J. D. A., Smits, B. M. G., Mul, J. D., Mudde, J., Verheul, M., Nieuwenhuizen, O. F. M., Cools, A. R., Ronken, E., Cremers, T., Schoffelmeer, A. N. M., Ellenbroek, B. A., & Cuppen, E. (2007). Characterization of the serotonin transporter knockout rat: A selective change in the functioning of the serotonergic system. Neuroscience, 146(4), 1662-1676. https://doi.org/10.1016/j.neuroscience.2007.03.030
2005
- Smits, B. M. G., Peters, T. A., Mul, J. D., Croes, H. J., Fransen, J. A. M., Beynon, A. J., Guryev, V., Plasterk, R. H. A., & Cuppen, E. (2005). Identification of a rat model for Usher syndrome type 1B by N-ethyl-N-nitrosourea mutagenesis-driven forward genetics. Genetics, 170(4), 1887-1896. https://doi.org/10.1534/genetics.105.044222
2024
2023
- Shemery, A. M., Zendlo, M., Kowalski, J., Gorrell, E., Everett, S., Wagner, J. G., Davis, A. E., Koch, L. G., Britton, S. L., Mul, J. D., Novak, C. M. & Koch, L. (2023). Reduced contextually induced muscle thermogenesis in rats with calorie restriction and lower aerobic fitness but not monogenic obesity. Taylor & Francis. https://doi.org/10.6084/m9.figshare.21967502.v1
- Shemery, A. M., Zendlo, M., Kowalski, J., Gorrell, E., Everett, S., Wagner, J. G., Davis, A. E., Koch, L. G., Britton, S. L., Mul, J. D. & Novak, C. M. (2023). Reduced contextually induced muscle thermogenesis in rats with calorie restriction and lower aerobic fitness but not monogenic obesity. Taylor & Francis. https://doi.org/10.6084/m9.figshare.21967502.v2
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Shiba, A., Hardonk, M. H., Foppen, E., Kool, T., la Fleur, S. E., Lucassen, P. J., Yi, C. X., Stenvers, D. J., Mul, J. D., & Kalsbeek, A. (2025). Voluntary Running and Estrous Cycle Modulate ΔFOSB in the Suprachiasmatic Nucleus of the Wistar Rat. Journal of Circadian Rhythms, 23, Article 7.