Sohn, J., Suzuki, M., Youssef, M., Hatada, S., Larkum, M.E., Kawaguchi, Y. & Kubota, Y. (2022)
Presynaptic supervision of cortical spine dynamics in motor learning.
Science Advances 8(30):eabm0531. https://doi.org/10.1126/sciadv.abm0531
Suzuki, M., Aru, J. & Larkum, M.E. (2021) Double-µPeriscope, a tool for multi-layer optical recordings, optogenetic stimulations or both.
eLife 10:e72894. https://doi.org/10.7554/eLife.72894
Aru, J., Suzuki, M. & Larkum, M.E. (2020) Cellular mechanisms of conscious processing.
Trends in Cognitive Sciences 24(10):814-825. https://doi.org/10.1016/j.tics.2020.07.006
Suzuki, M. & Larkum, M.E. (2020) General anesthesia decouples cortical pyramidal neurons.
Cell 180(4):666-676. https://doi.org/10.1016/j.cell.2020.01.024
Suzuki, M. & Larkum, M.E. (2017) Dendritic calcium spikes are clearly detectable at the cortical surface.
Nature Communications 8(1):276. http://doi.org/10.1038/s41467-017-00282-4
Suzuki, M. & Gottlieb, J. (2013) Distinct neural mechanisms of distractor suppression in the frontal and parietal lobe.
Nature Neuroscience 16(1):98-104. http://dx.doi.org/10.1038/nn.3282
In 2020 Jaan Aru, Matthew Larkum and I formulated the Dendritic Integration Theory (DIT; Aru, Suzuki & Larkum, Trends Cogn Sci 2020). The theory posits that apical dendrites of cortical layer 5 pyramidal neurons play a central role in integrating large-scale cortico-cortical and thalamo-cortical loops that are essential for conscious perception. Unlike many abstract theories previously proposed, a distinguishing feature of DIT is that the theory spotlights a specific cellular mechanism—pyramidal cell dendrites—as the fulcrum at which these two apparently-orthogonal loops intersect.
DIT makes a lot of testable predictions and my team will experimentally test these predictions using novel micro-optical tools (see below). The research questions of particular relevance to DIT include, but not limited to:
My previous studies demonstrated that novel micro-optical tools enabled unprecedented experiments and led to unexpected findings (Suzuki & Larkum, Nat Commun 2017; Suzuki & Larkum, Cell 2020; Suzuki et al., eLife 2021). My team aims to further develop novel tools that have the potential to enable us to make ground-breaking discoveries.
With Prof. Cyriel Pennartz and Dr. Jaan Aru, I am currently developing a new theory based on our previous research findings. The paper is expected to be published in 2023. Experiments driven by the new theory will follow. Prof. Pennartz and I also collaborate in the Zwaartekracht (Gravitation) grant for holographic imaging and stimulation. With Dr. Umberto Olcese, we aim to understand the large-scale thalamo-cortical network while animals are engaged in a multimodal sensory integration task. Another topic of interest for our collaboration is the cellular mechanisms of sleep. With Dr. Conrado Bosman, the cross-species analysis of cortical layer 5 pyramidal neurons and their dendritic calcium spikes as well as the application of the micro-optical probe I have recently developed to the ferret cortex in vivo is the current target. With computational neuroscientist Dr. Jorge Mejias, we combine experimental and computational approaches to study dendritic calcium spikes and cortico-thalamic interactions. With Dr. Jan Willem de Gee, neuromodulators are one of our common interests for collaborations. With him, clinical translation of my basic research findings will be sought.