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NL

dr. R. (Renée) van Amerongen

Faculty of Science
Swammerdam Institute for Life Sciences
Photographer: Liesbeth Dingemans

Visiting address
  • Science Park 904
  • Room number: C2.261
Postal address
  • Postbus 1212
    1000 BE Amsterdam
  • About me

    Work experience

    2017 - present: associate professor (tenured) 

    2013 - 2017: MacGillavry fellow and tenure track assistant professor at the University of Amsterdam

    2011 - 2013: senior postdoc with prof.dr. Daniel Peeper at the Netherlands Cancer Institute

    2008 - 2011: postdoc with prof.dr. Roel Nusse at Stanford University, USA

    1999 - 2005: PhD thesis research with prof.dr. Anton Berns at the Netherlands Cancer Institute 

     

    Education

    2005 PhD (cum laude) from the Universiteit van Amsterdam

    1999 MSc (cum laude) from the  Vrije Universiteit Amsterdam

     

    Honors and Awards

    2014 NWO VIDI grant

    2013 NWO Aspasia (declined)

    2013 KWF persoonsgebonden financiering

    2013  MacGillavry fellowship

    2007 4-year KWF fellowship for fundamental cancer research 

    2007 longterm EMBO fellowship 

  • Research Interests
    Cells are the building blocks of the human body.

     

     

    Development of a multicellular organism requires tight control of cell proliferation, differentiation and polarized cell movements to ensure the correct assembly of cells into complex tissues. But how does a single fertilized oocyte ultimately grow out into a complex animal with billions of specialized cells that carry out very different functions? And how is tissue function and integrity maintained in the adult? These are central questions in biology.

     

     

    The same molecular mechanisms that normally guide these biological processes in the developing embryo, maintain tissue homeostasis in the adult. When disrupted, they are the underlying cause of degenerative diseases, tumor formation and, ultimately, aging.

    My goal is to translate principles of developmental and stem cell biology to cancer research and regenerative medicine. In this, I combine my background in molecular genetics and oncology with my experience in developmental biology and stem cell research. Focusing on Wnt signal transduction in the context of mammary gland development and breast cancer, my research team aims to understand the molecular mechanisms that control complex and dynamic cell behavior in development and disease.

     

    For more information, visit our lab website

    All multicellular animals use Wnt signal transduction as a molecular mechanism to control cell division, differentiation and movement. How this pathway operates at the molecular level to control complex cell behavior in 3D space and time remains incompletely understood.
  • Publications

    2018

    2017

    • van de Moosdijk, A. A. A., Fu, N. Y., Rios, A. C., Visvader, J. E., & van Amerongen, R. (2017). Lineage Tracing of Mammary Stem and Progenitor Cells. In F. Martin, T. Stein, & J. Howlin (Eds.), Mammary Gland Development: Methods and Protocols (pp. 291-308). (Methods in Molecular Biology). New York: Humana Press. https://doi.org/10.1007/978-1-4939-6475-8_15 [details]

    2016

    2015

    • Glukhova, M. A., Hynes, N., Vivanco, DM., van Amerongen, R., Clarke, R. B., & Bentires-Alj, M. (2015). The seventh ENBDC workshop on methods in mammary gland development and cancer. Breast Cancer Research, 17, [119]. https://doi.org/10.1186/s13058-015-0629-5 [details]
    • van Amerongen, R. (2015). Lineage Tracing in the Mammary Gland Using Cre/lox Technology and Fluorescent Reporter Alleles. In M. Vivanco del Mar (Ed.), Mammary Stem Cells: methods and protocols (pp. 187-211). (Methods in Molecular Biology; No. 1293). New York: Humana Press. https://doi.org/10.1007/978-1-4939-2519-3_11 [details]

    2014

    2013

    • Lim, X., Tan, S. H., Koh, W. L. C., Chau, R. M. W., Yan, K. S., Kuo, C. J., ... Nusse, R. (2013). Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling. Science, 342(6163), 1226-1230. https://doi.org/10.1126/science.1239730 [details]
    This list of publications is extracted from the UvA-Current Research Information System. Questions? Ask the library or the Pure staff of your faculty / institute. Log in to Pure to edit your publications. Log in to Personal Page Publication Selection tool to manage the visibility of your publications on this list.
  • Ancillary activities
    • No ancillary activities