dr. R. (Renée) van Amerongen
- Science Park 904
- Room number: C2.261
- Postbus 1212
1000 BE Amsterdam
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About me
Work experience
2017 - present: associate professor (tenured)
2013 - 2017: MacGillavry fellow and tenure track assistant professor at the University of Amsterdam
2011 - 2013: senior postdoc with prof.dr. Daniel Peeper at the Netherlands Cancer Institute
2008 - 2011: postdoc with prof.dr. Roel Nusse at Stanford University, USA
1999 - 2005: PhD thesis research with prof.dr. Anton Berns at the Netherlands Cancer Institute
Education
2005 PhD (cum laude) from the Universiteit van Amsterdam
1999 MSc (cum laude) from the Vrije Universiteit Amsterdam
Honors and Awards
2014 NWO VIDI grant
2013 NWO Aspasia (declined)
2013 KWF persoonsgebonden financiering
2013 MacGillavry fellowship
2007 4-year KWF fellowship for fundamental cancer research
2007 longterm EMBO fellowship
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Research Interests
Cells are the building blocks of the human body. Development of a multicellular organism requires tight control of cell proliferation, differentiation and polarized cell movements to ensure the correct assembly of cells into complex tissues. But how does a single fertilized oocyte ultimately grow out into a complex animal with billions of specialized cells that carry out very different functions? And how is tissue function and integrity maintained in the adult? These are central questions in biology.
The same molecular mechanisms that normally guide these biological processes in the developing embryo, maintain tissue homeostasis in the adult. When disrupted, they are the underlying cause of degenerative diseases, tumor formation and, ultimately, aging.
My goal is to translate principles of developmental and stem cell biology to cancer research and regenerative medicine. In this, I combine my background in molecular genetics and oncology with my experience in developmental biology and stem cell research. Focusing on Wnt signal transduction in the context of mammary gland development and breast cancer, my research team aims to understand the molecular mechanisms that control complex and dynamic cell behavior in development and disease.
For more information, visit our lab website.
All multicellular animals use Wnt signal transduction as a molecular mechanism to control cell division, differentiation and movement. How this pathway operates at the molecular level to control complex cell behavior in 3D space and time remains incompletely understood. -
Publications
2020
- van Amerongen, R. (2020). Celebrating Discoveries in Wnt Signaling: How One Man Gave Wings to an Entire Field. Cell. https://doi.org/10.1016/j.cell.2020.03.033
van Schie, E. H., & van Amerongen, R. (2020). Aberrant WNT/CTNNB1 Signaling as a Therapeutic Target in Human Breast Cancer: Weighing the Evidence. Frontiers in cell and developmental biology, 8, [25]. https://doi.org/10.3389/fcell.2020.00025 [details]- van der Wal, T., Lambooij, J-P., & van Amerongen, R. (2020). TMEM98 is a negative regulator of FRAT mediated Wnt/ß-catenin signalling. PLoS ONE, 15(1), e0227435. https://doi.org/10.1371/journal.pone.0227435
2018
- Wiese, K. E., Nusse, R., & van Amerongen, R. (2018). Wnt signaling: conquering complexity. Development - The Company of Biologists, 145(12), [dev165902]. https://doi.org/10.1242/dev.165902 [details]
2017
- van de Moosdijk, A. A. A., Fu, N. Y., Rios, A. C., Visvader, J. E., & van Amerongen, R. (2017). Lineage Tracing of Mammary Stem and Progenitor Cells. In F. Martin, T. Stein, & J. Howlin (Eds.), Mammary Gland Development: Methods and Protocols (pp. 291-308). (Methods in Molecular Biology). New York: Humana Press. https://doi.org/10.1007/978-1-4939-6475-8_15 [details]
2016
- Boelens, M. C., Nethe, M., Klarenbeek, S., de Ruiter, J. R., Schut, E., Bonzanni, N., ... Jonkers, J. (2016). PTEN Loss in E-Cadherin-Deficient Mouse Mammary Epithelial Cells Rescues Apoptosis and Results in Development of Classical Invasive Lobular Carcinoma. Cell Reports, 16(8), 2087-2101. https://doi.org/10.1016/j.celrep.2016.07.059 [details]
- Jacobsen, A., Heijmans, N., Verkaar, F., Smit, M. J., Heringa, J., van Amerongen, R., & Feenstra, K. A. (2016). Construction and Experimental Validation of a Petri Net Model of Wnt/β-Catenin Signaling. PLoS ONE, 11(5), [e0155743]. https://doi.org/10.1371/journal.pone.0155743 [details]
- Lloyd-Lewis, B., van de Moosdijk, A. A. A., Bentires-Alj, M., Clarke, R. B., & van Amerongen, R. (2016). Complexity galore: 3D cultures, biomechanics and systems medicine at the eighth ENBDC workshop "Methods in Mammary Gland Development and Cancer". Breast Cancer Research, 18, [115]. https://doi.org/10.1186/s13058-016-0777-2 [details]
- Loh, K. M., van Amerongen, R., & Nusse, R. (2016). Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals. Developmental Cell, 38(6), 643-655. https://doi.org/10.1016/j.devcel.2016.08.011 [details]
- van de Moosdijk, A. A. A., & van Amerongen, R. (2016). Identification of reliable reference genes for qRT-PCR studies of the developing mouse mammary gland. Scientific Reports, 6, [35595]. https://doi.org/10.1038/srep35595 [details]
2015
- Glukhova, M. A., Hynes, N., Vivanco, DM., van Amerongen, R., Clarke, R. B., & Bentires-Alj, M. (2015). The seventh ENBDC workshop on methods in mammary gland development and cancer. Breast Cancer Research, 17, [119]. https://doi.org/10.1186/s13058-015-0629-5 [details]
- van Amerongen, R. (2015). Lineage Tracing in the Mammary Gland Using Cre/lox Technology and Fluorescent Reporter Alleles. In M. Vivanco del Mar (Ed.), Mammary Stem Cells: methods and protocols (pp. 187-211). (Methods in Molecular Biology; No. 1293). New York: Humana Press. https://doi.org/10.1007/978-1-4939-2519-3_11 [details]
2014
- Green, J., Nusse, R., & van Amerongen, R. (2014). The role of Ryk and Ror receptor tyrosine kinases in Wnt signal transduction. Cold Spring Harbor Perspectives in Biology, 6(2), 009175. https://doi.org/10.1101/cshperspect.a009175 [details]
- Kemper, K., de Goeje, P. L., Peeper, D. S., & van Amerongen, R. (2014). Phenotype switching: tumor cell plasticity as a resistance mechanism and target for therapy. Cancer Research, 74(21), 5937-5941. https://doi.org/10.1158/0008-5472.CAN-14-1174 [details]
- Rinkevich, Y., Montoro, D. T., Contreras-Trujillo, H., Harari-Steinberg, O., Newman, A. M., Tsai, J. M., ... Dekel, B. (2014). In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration. Cell Reports, 7(4), 1270-1283. https://doi.org/10.1016/j.celrep.2014.04.018 [details]
- Shehata, M., van Amerongen, R., Zeeman, A. L., Giraddi, R. R., & Stingl, J. (2014). The influence of tamoxifen on normal mouse mammary gland homeostasis. Breast Cancer Research, 16(4), 411. https://doi.org/10.1186/s13058-014-0411-0 [details]
- van Amerongen, R. (2014). Bipotent mammary stem cells: now in amazing 3D. Breast Cancer Research, 2014(16), 480. https://doi.org/10.1186/s13058-014-0480-0 [details]
2013
- Lim, X., Tan, S. H., Koh, W. L. C., Chau, R. M. W., Yan, K. S., Kuo, C. J., ... Nusse, R. (2013). Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling. Science, 342(6163), 1226-1230. https://doi.org/10.1126/science.1239730 [details]
2015
- van Amerongen, R. (2015). short interview: Biologie was achteraf gezien juiste keuze. Het Parool.
This list of publications is extracted from the UvA-Current Research Information System. Questions? Ask the library or the Pure staff of your faculty / institute. Log in to Pure to edit your publications. Log in to Personal Page Publication Selection tool to manage the visibility of your publications on this list. -
Ancillary activities
- No ancillary activities
van Schie, E. H., & van Amerongen, R. (2020). Aberrant WNT/CTNNB1 Signaling as a Therapeutic Target in Human Breast Cancer: Weighing the Evidence. Frontiers in cell and developmental biology, 8, [25].