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Dr. C.J. (Caitrín) Crudden PhD

Universitair Docent
Faculteit der Natuurwetenschappen, Wiskunde en Informatica
Swammerdam Institute for Life Sciences
Bezoekadres
  • Science Park 904
  • Kamernummer: C2.103
Postadres
Contactgegevens
  • Publicaties

    2025

    • Mobach, S., Bergkamp, N. D., Ma, Z., Haselager, M. V., Anbuhl, S. M., Jurriens, D., van den Bor, J., Wang, Z., Crudden, C., Roos, J. L., Perez Almeria, C. V., Boergonje, R. A., Lohse, M. J., Bosma, R., Eldering, E., Siderius, M., Wu, W., Spaargaren, M., Tonino, S. H., ... Heukers, R. (2025). Disruption of constitutive CXCR4 oligomers impairs oncogenic properties in lymphoid neoplasms. Proceedings of the National Academy of Sciences, 122(24), Article e2424186122. https://doi.org/10.1073/pnas.2424186122
    • Perez Almeria, C. V., Otun, O., Schlimgen, R., Lamme, T. D., Di Niro, L., Crudden, C., Bebelman, J. P., Youssef, N., Musli, L., Jenjak, S., Bobkov, V., Drube, J., Hoffmann, C., Volkman, B. F., Granier, S., Bechara, C., Siderius, M., Heukers, R., Schafer, C. T., & Smit, M. J. (2025). Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies. Nature Communications, 16, Article 10828. https://doi.org/10.1038/s41467-025-65858-x

    2024

    • Di Niro, L., Linders, A. C., Glynn, T., Pegtel, D. M., Siderius, M., Crudden, C., & Smit, M. J. (2024). G protein-coupled receptors: a gateway to targeting oncogenic EVs? Extracellular Vesicles and Circulating Nucleic Acids, 5(2), 233-248. https://doi.org/10.20517/evcna.2024.10

    2023

    • Bebelman, M. P., Setiawan, I. M., Bergkamp, N. D., van Senten, J. R., Crudden, C., Bebelman, J. P. M., Verweij, F. J., van Niel, G., Siderius, M., Pegtel, D. M., & Smit, M. J. (2023). Exosomal release of the virus-encoded chemokine receptor US28 contributes to chemokine scavenging. iScience, 26(8), Article 107412. https://doi.org/10.1016/j.isci.2023.107412
    • Cismas, S., Pasca, S., Crudden, C., Trocoli Drakensjo, I., Suleymanova, N., Zhang, S., Gebhard, B., Song, D., Neo, S., Shibano, T., Smith, T. J., Calin, G. A., Girnita, A., & Girnita, L. (2023). Competing Engagement of β-arrestin Isoforms Balances IGF1R/p53 Signaling and Controls Melanoma Cell Chemotherapeutic Responsiveness. Molecular Cancer Research, 21(12), 1288-1302. https://doi.org/10.1158/1541-7786.MCR-22-0871
    • Song, D., Cismas, S., Crudden, C., Trocme, E., Worrall, C., Suleymanova, N., Lin, T., Zheng, H., Seregard, S., Girnita, A., & Girnita, L. (2023). Correction: IGF-1R is a molecular determinant for response to p53 reactivation therapy in conjunctival melanoma. Oncogene, 42(11), 858. https://doi.org/10.1038/s41388-023-02607-8

    2022

    • Song, D., Cismas, S., Crudden, C., Trocme, E., Worrall, C., Suleymanova, N., Lin, T., Zheng, H., Seregard, S., Girnita, A., & Girnita, L. (2022). IGF-1R is a molecular determinant for response to p53 reactivation therapy in conjunctival melanoma. Oncogene, 41(4), 600-611. https://doi.org/10.1038/s41388-021-02111-x

    2021

    • Bebelman, M. P., Janssen, E., Pegtel, D. M., & Crudden, C. (2021). The forces driving cancer extracellular vesicle secretion. Neoplasia, 23(1), 149-157. https://doi.org/10.1016/j.neo.2020.11.011
    • Crudden, C., Shibano, T., Song, D., Dragomir, M. P., Cismas, S., Serly, J., Nedelcu, D., Fuentes-Mattei, E., Tica, A., Calin, G. A., Girnita, A., & Girnita, L. (2021). Inhibition of G Protein-Coupled Receptor Kinase 2 Promotes Unbiased Downregulation of IGF1 Receptor and Restrains Malignant Cell Growth. Cancer Research, 81(2), 501-514. https://doi.org/10.1158/0008-5472.CAN-20-1662

    2020

    2019

    • Crudden, C., Song, D., Cismas, S., Trocmé, E., Pasca, S., Calin, G. A., Girnita, A., & Girnita, L. (2019). Below the Surface: IGF-1R Therapeutic Targeting and Its Endocytic Journey. Cells, 8(10). https://doi.org/10.3390/cells8101223

    2018

    • Crudden, C., Shibano, T., Song, D., Suleymanova, N., Girnita, A., & Girnita, L. (2018). Blurring Boundaries: Receptor Tyrosine Kinases as functional G Protein-Coupled Receptors. International review of cell and molecular biology, 339, 1-40. https://doi.org/10.1016/bs.ircmb.2018.02.006
    • Lohcharoenkal, W., Das Mahapatra, K., Pasquali, L., Crudden, C., Kular, L., Akkaya Ulum, Y. Z., Zhang, L., Xu Landén, N., Girnita, L., Jagodic, M., Ståhle, M., Sonkoly, E., & Pivarcsi, A. (2018). Genome-Wide Screen for MicroRNAs Reveals a Role for miR-203 in Melanoma Metastasis. Journal of Investigative Dermatology, 138(4), 882-892. https://doi.org/10.1016/j.jid.2017.09.049

    2017

    • Suleymanova, N., Crudden, C., Shibano, T., Worrall, C., Oprea, I., Tica, A., Calin, G. A., Girnita, A., & Girnita, L. (2017). Functional antagonism of β-arrestin isoforms balance IGF-1R expression and signalling with distinct cancer-related biological outcomes. Oncogene, 36(41), 5734-5744. https://doi.org/10.1038/onc.2017.179
    • Suleymanova, N., Crudden, C., Worrall, C., Dricu, A., Girnita, A., & Girnita, L. (2017). Enhanced response of melanoma cells to MEK inhibitors following unbiased IGF-1R down-regulation. Oncotarget, 8(47), 82256-82267. https://doi.org/10.18632/oncotarget.19286
    • Worrall, C., Suleymanova, N., Crudden, C., Trocoli Drakensjö, I., Candrea, E., Nedelcu, D., Takahashi, S. I., Girnita, L., & Girnita, A. (2017). Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma. Oncogene, 36(23), 3274-3286. https://doi.org/10.1038/onc.2016.472

    2016

    • Girnita, L., Girnita, A., & Crudden, C. (2016). Differential Regulation of IGF-1 and Insulin Signaling by GRKs. In G Protein-Coupled Receptor Kinases (pp. 151-171). (Methods in Pharmacology and Toxicology). Humana Press. https://doi.org/10.1007/978-1-4939-3798-1_7
    • Girnita, L., Takahashi, S. I., Crudden, C., Fukushima, T., Worrall, C., Furuta, H., Yoshihara, H., Hakuno, F., & Girnita, A. (2016). Chapter Seven - When Phosphorylation Encounters Ubiquitination: A Balanced Perspective on IGF-1R Signaling. In S. K. Shenoy (Ed.), Ubiquitination and Transmembrane Signaling (pp. 277-311). (Progress in Molecular Biology and Translational Science; Vol. 141). Elsevier B.V. https://doi.org/10.1016/bs.pmbts.2016.04.001

    2015

    • Crudden, C., Girnita, A., & Girnita, L. (2015). Targeting the IGF-1R: The Tale of the Tortoise and the Hare. Frontiers in Endocrinology, 6, 64. https://doi.org/10.3389/fendo.2015.00064
    • Crudden, C., Ilic, M., Suleymanova, N., Worrall, C., Girnita, A., & Girnita, L. (2015). The dichotomy of the Insulin-like growth factor 1 receptor: RTK and GPCR: friend or foe for cancer treatment? Growth Hormone & IGF Research, 25(1), 2-12. https://doi.org/10.1016/j.ghir.2014.10.002

    2024

    • Perez Almeria, C. V., Otun, O., Schlimgen, R., Lamme, T. D., Crudden, C., Youssef, N., Musli, L., Jenjak, S., Bobkov, V., Drube, J., Hoffmann, C., Volkman, B. F., Granier, S., Bechara, C., Siderius, M., Heukers, R., Schafer, C. T., & Smit, M. J. (2024). Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies. BioRxiv. https://doi.org/10.1101/2024.11.04.621790

    2023

    • Crudden, C. J. (2023). Luminescence-based screening for extracellular vesicle release modulators reveals a role for PI4KIIIβ in exosome biogenesis upon lysosome inhibition. https://doi.org/10.1101/2023.02.23.529257

    Prijs / subsidie

    • Crudden, C. (2022). ZonMw Off-Road Grant.
    • Crudden, C. (2021). ZonMw Veni Fellowship; 09150162010212.
    • Crudden, C. (2018). Marie Skłodowska-Curie Fellowship; 845391.
    This list of publications is extracted from the UvA-Current Research Information System. Questions? Ask the library or the Pure staff of your faculty / institute. Log in to Pure to edit your publications. Log in to Personal Page Publication Selection tool to manage the visibility of your publications on this list.
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