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Prof. dr. M.W.M. (Michiel) van den Brekel

Oncological Voice and Speech Impediments (chair in co-operation with the Netherlands Cancer Institute)
Faculty of Humanities
Capaciteitsgroep Taalwetenschap
Photographer: Jeroen Oerlemans

Visiting address
  • Spuistraat 134
  • Room number: 630
Postal address
  • Postbus 1642
    1000 BP Amsterdam
Contact details
  • Profile

    Interview

    Not only is Michiel van den Brekel professor at the Faculty of Humanities, he is also head of the department of Head and Neck Oncology and Surgery at the Netherlands Cancer Institute and a staff member in the department of Otorhinolaryngology at the Amsterdam Academic Medical Centre. Appointed as Professor of Oncology-Related Voice and Speech Disorders in 2011, Van den Brekel is excited about the prospect of helping to further the cooperative relationship between the humanities and medicine.  A fertile ground for cooperation The idea that a university chair with the medical name 'oncology related voice and speech disorders' could form part of a humanities faculty seems counterintuitive, if not downright absurd. Indeed, thinking of medicine and humanities, one is easily excused for viewing these two disciplines as polar opposites, with little or nothing in common. And yet, on closer inspection, the links between them are as strong as they are beneficial; something to which Van den Brekel's own chair attests. Said Van den Brekel: 'Within the ACLC (Amsterdam Center for Language and Communication) there is substantial knowledge about speech, articulation and language, which can be practically applied within head and neck oncology. One of the goals of the research group is to ascertain whether patients can compensate for changes in voice and speech, and if yes, in what way? The ACLC plays a pivotal role in the linguistic side of the rehabilitation process. With the help of speech technology, our aim is to get a more comprehensive insight into the possible consequences an operation might have on a patient, so that we are able to provide better counseling about the various treatment options that are available.' Linking the fields of humanities and medicine  One of Van den Brekel's research fields is oncology related voice and speech disorders, which is a subject area in which the Faculty of Humanities provides unique expertise. Head and neck cancer is the sixth most common type of cancer in the Netherlands, with approximately 3000 patients treated for this disease annually. Van den Brekel: "Many patients with a tumor in their larynx and throat end up with impairments in speech and have difficulty swallowing partly as a result of the treatment. The research into these impairments can be done from both a medical and academic perspective.'  To illustrate the unique role that the humanities can play in oncology, Van den Brekel mentions a research project currently being carried out by one of the Faculty's PhD candidates, whereby speech technology is used for exploring a patient's comprehensibility and quality of voice after oncological treatment. As yet, patients suffering from voice and speech impairment after an operation usually visit a speech therapist, who then gives them exercises to do. In most cases both speech therapist and patient usually believe they're able to detect improvements after a few months of exercise, which is by no means an objective assumption. In this sense speech therapy is still a relatively young science. It would therefore be advantageous to use voice recognition software that automatically measures such things as speech quality, comprehension and all sorts of aspects surrounding articulation. In using such a device, both patient and speech therapist would be better informed about the current stage of rehabilitation and what still needs to be done. This is a process in which linguistic knowledge and techniques can play a major role.  A stimulating environment It is now almost a year since Van den Brekel started working at the Faculty of Humanities, which begs the question: does he feel like a humanities scholar? 'Although I'm a physician above all, I do enjoy working at the Faculty. As a medical practitioner you're mostly confined to a hospital. It's therefore really refreshing to see people at this Faculty engaged in totally different things. My own chair forms a beneficial link between the Faculty of Humanities and the medical world

    Link
  • Publications

    2021

    • Beck, A. C. C., van Harten, W. H., van den Brekel, M. W. M., Navran, A., & Retèl, V. P. (2021). Cost-effectiveness of surgery versus organ preservation in advanced laryngeal cancer. Laryngoscope, 131(2), E509-E517. https://doi.org/10.1002/lary.28954
    • Bos, P., van den Brekel, M. W. M., Gouw, Z. A. R., Al-Mamgani, A., Taghavi, M., Waktola, S., Aerts, H. J. W. L., Castelijns, J. A., Beets-Tan, R. G. H., & Jasperse, B. (2021). Improved outcome prediction of oropharyngeal cancer by combining clinical and MRI features in machine learning models. European Journal of Radiology, 139, [109701]. https://doi.org/10.1016/j.ejrad.2021.109701
    • Bos, P., van den Brekel, M. W. M., Gouw, Z. A. R., Al-Mamgani, A., Waktola, S., Aerts, H. J. W. L., Beets-Tan, R. G. H., Castelijns, J. A., & Jasperse, B. (2021). Clinical variables and magnetic resonance imaging-based radiomics predict human papillomavirus status of oropharyngeal cancer. Head and Neck, 43(2), 485-495. https://doi.org/10.1002/hed.26505
    • Bos, P., van der Hulst, H. J., van den Brekel, M. W. M., Schats, W., Jasperse, B., Beets-Tan, R. G. H., & Castelijns, J. A. (2021). Prognostic functional MR imaging parameters in head and neck squamous cell carcinoma: A systematic review. European Journal of Radiology, 144, [109952]. https://doi.org/10.1016/j.ejrad.2021.109952
    • Brouwer de Koning, S. G., Schaeffers, A. W. M. A., Schats, W., van den Brekel, M. W. M., Ruers, T. J. M., & Karakullukcu, M. B. (2021). Assessment of the deep resection margin during oral cancer surgery: A systematic review. European Journal of Surgical Oncology, 47(9), 2220-2232. https://doi.org/10.1016/j.ejso.2021.04.016
    • Buckle, T., van Alphen, M., van Oosterom, M. N., van Beurden, F., Heimburger, N., van der Wal, J. E., van den Brekel, M., van Leeuwen, F. W. B., & Karakullukcu, B. (2021). Translation of c‐met targeted image‐guided surgery solutions in oral cavity cancer—initial proof of concept data. Cancers, 13(11), [2674]. https://doi.org/10.3390/cancers13112674
    • Hamming-Vrieze, O., van Kranen, S., Walraven, I., Navran, A., Al-Mamgani, A., Tesselaar, M., van den Brekel, M., & Sonke, J. J. (2021). Deterioration of intended target volume radiation dose due to anatomical changes in patients with head-and-neck cancer. Cancers, 13(17), [4253]. https://doi.org/10.3390/cancers13174253
    • Henneman, R., Schats, W., Karakullukcu, M. B., van den Brekel, M. W. M., Smeele, L. E., Lohuis, P. F. J. M., van der Hage, J. A., Al-Mamgani, A., & Balm, A. J. M. (2021). Surgical site complications of post-chemoradiotherapy neck dissection: Urgent need for standard registration. European Journal of Surgical Oncology, 47(4), 764-771. https://doi.org/10.1016/j.ejso.2020.10.015
    • Karsten, R. T., Chargi, N., van der Molen, L., van Son, R. J. J. H., de Bree, R., Al-Mamgani, A., de Boer, J. P., Hilgers, F. J. M., van den Brekel, M. W. M., Smeele, L. E., & Stuiver, M. M. (2021). Dysphagia, trismus and speech impairment following radiation-based treatment for advanced stage oropharyngeal carcinoma: a one-year prospective evaluation. European Archives of Oto-Rhino-Laryngology. https://doi.org/10.1007/s00405-021-06870-x
    • Leemans, M., Muller, S. H., van Alphen, M. J. A., Vallenduuk, W., Dirven, R., & van den Brekel, M. W. M. (2021). Adjustable breathing resistance for laryngectomized patients: Proof of principle in a novel heat and moisture exchanger cassette. Head and Neck, 43(4), 1073-1087. https://doi.org/10.1002/hed.26571
    • Leemans, M., Van Alphen, M. J. A., Dirven, R., Verkerke, G. J., Hekman, E. E. G., & Van Den Brekel, M. W. M. (2021). Improving hands-free speech rehabilitation in laryngectomized patients: Preliminary results of a novel intratracheal fixation device. In Proceedings of the 2021 Design of Medical Devices Conference, DMD 2021 [V001T12A001] (Proceedings of the 2021 Design of Medical Devices Conference, DMD 2021). American Society of Mechanical Engineers. https://doi.org/10.1115/DMD2021-1009
    • Leemans, M., van Alphen, M. J. A., Dirven, R., Verkerke, G. J., Hekman, E. E. G., & van den Brekel, M. W. M. (2021). Improving hands-free speech rehabilitation in laryngectomized patients – proof of concept of a novel intratracheal fixation device. Otolaryngology-Head and Neck Surgery, 165(2), 317-320. https://doi.org/10.1177/0194599820982634 [details]
    • Succaria, F., Kvistborg, P., Stein, J. E., Engle, E. L., McMiller, T. L., Rooper, L. M., Thompson, E., Berger, A. E., van den Brekel, M., Zuur, C. L., Haanen, J., Topalian, S. L., & Taube, J. M. (2021). Characterization of the tumor immune microenvironment in human papillomavirus-positive and -negative head and neck squamous cell carcinomas. Cancer Immunology, Immunotherapy, 70(5), 1227-1237. https://doi.org/10.1007/s00262-020-02747-w
    • de Koekkoek-Doll, P. K., Maas, M., Vogel, W., Castelijns, J., Smit, L., Zavrakidis, I., Beets-Tan, R., & van den Brekel, M. (2021). Real-time ultrasound image fusion with FDG-PET/CT to perform fused image-guided fine-needle aspiration in neck nodes: Feasibility and diagnostic value. American journal of neuroradiology, 42(3), 566-572. https://doi.org/10.3174/AJNR.A6938
    • de Koekkoek-Doll, P. K., Roberti, S., van den Brekel, M. W., Maas, M., Smit, L., Beets-Tan, R., & Castelijns, J. (2021). Value of assessing peripheral vascularization with micro-flow imaging, resistive index and absent hilum sign as predictor for malignancy in lymph nodes in head and neck squamous cell carcinoma. Cancers, 13(20), [5071]. https://doi.org/10.3390/cancers13205071
    • van Sluis, K. E., van Son, R. J. J. H., van der Molen, L., MCGuinness, A. J., Palme, C. E., Novakovic, D., Stone, D., Natsis, L., Charters, E., Jones, K., Dirven, R., & van den Brekel, M. W. M. (2021). Multidimensional evaluation of voice outcomes following total laryngectomy: a prospective multicenter cohort study. European Archives of Oto-Rhino-Laryngology, 278(4), 1209–1222. https://doi.org/10.1007/s00405-020-06216-z [details]
    • van der Hout, A., Holtmaat, K., Jansen, F., Lissenberg-Witte, B. I., van Uden-Kraan, C. F., Nieuwenhuijzen, G. A. P., Hardillo, J. A., Baatenburg de Jong, R. J., Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J. E., Bosscha, K., van den Brekel, M. W. M., Petersen, J. F., Westerman, M., Honings, J., Takes, R. P., ... Verdonck-de Leeuw, I. M. (2021). The eHealth self-management application ‘Oncokompas’ that supports cancer survivors to improve health-related quality of life and reduce symptoms: which groups benefit most? Acta oncologica, 60(4), 403-411. https://doi.org/10.1080/0284186X.2020.1851764
    • van der Hout, A., Jansen, F., van Uden-Kraan, C. F., Coupé, V. M., Holtmaat, K., Nieuwenhuijzen, G. A., Hardillo, J. A., de Jong, R. J. B., Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J. E., Bosscha, K., van den Brekel, M. W. M., Petersen, J. F., Westerman, M., Honings, J., Takes, R. P., ... Verdonck-de Leeuw, I. M. (2021). Cost-utility of an eHealth application ‘Oncokompas’ that supports cancer survivors in self-management: results of a randomised controlled trial. Journal of Cancer Survivorship, 15(1), 77-86. https://doi.org/10.1007/s11764-020-00912-9
    • van der Hout, A., van Uden-Kraan, C. F., Holtmaat, K., Jansen, F., Lissenberg-Witte, B. I., Nieuwenhuijzen, G. A. P., Hardillo, J. A., Baatenburg de Jong, R. J., Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J. E., Bosscha, K., van den Brekel, M. W. M., Petersen, J. F., Westerman, M., Honings, J., Takes, R. P., ... Verdonck-de Leeuw, I. M. (2021). Reasons for not reaching or using web-based self-management applications, and the use and evaluation of Oncokompas among cancer survivors, in the context of a randomised controlled trial. Internet Interventions, 25, [100429]. https://doi.org/10.1016/j.invent.2021.100429

    2020

    • Arends, C. R., Petersen, J. F., van der Noort, V., Timmermans, A. J., Leemans, C. R., de Bree, R., van den Brekel, M. W. M., & Stuiver, M. M. (2020). Optimizing Survival Predictions of Hypopharynx Cancer: Development of a Clinical Prediction Model. The Laryngoscope, 130(9), 2166-2172. https://doi.org/10.1002/lary.28345 [details]
    • Baudelet, M., Van Den Steen, L., Duprez, F., De Bodt, M., Deschuymer, S., Goeleven, A., Hutsebaut, I., Mariën, S., Meersschout, S., Nevens, D., Nuyts, S., Peeters, M., Specenier, P., Van den Brekel, M., van der Molen, L., Vandenbruaene, C., Vanderveken, O., Van Dinther, J., Van Laer, C., ... Van Nuffelen, G. (2020). Study protocol for a randomized controlled trial: Prophylactic swallowing exercises in head-and-neck cancer patients treated with (chemo)radiotherapy (PRESTO trial). Trials, 21, [237]. https://doi.org/10.1186/s13063-020-4171-0
    • Beck, A. C. C., Retèl, V. P., Bunting, G., Sethi, R. K. V., Deschler, D. G., van den Brekel, M. W. M., & van Harten, W. H. (2020). Cost-effectiveness analysis of using the heat and moisture exchangers compared with alternative stoma covers in laryngectomy rehabilitation: US perspective. Head and Neck, 42(12), 3720-3734. https://doi.org/10.1002/hed.26442
    • Bogowicz, M., Jochems, A., Deist, T. M., Tanadini-Lang, S., Huang, S. H., Chan, B., Waldron, J. N., Bratman, S., O’Sullivan, B., Riesterer, O., Studer, G., Unkelbach, J., Barakat, S., Brakenhoff, R. H., Nauta, I., Gazzani, S. E., Calareso, G., Scheckenbach, K., Hoebers, F., ... Lambin, P. (2020). Privacy-preserving distributed learning of radiomics to predict overall survival and HPV status in head and neck cancer. Scientific Reports, 10(1), [4542]. https://doi.org/10.1038/s41598-020-61297-4
    • Buiting, H. M., de Bree, R., Brom, L., Mack, J. W., & van den Brekel, M. W. M. (2020). Humour and laughing in patients with prolonged incurable cancer: an ethnographic study in a comprehensive cancer centre. Quality of Life Research, 29(9), 2425-2434. https://doi.org/10.1007/s11136-020-02490-w
    • Elbers, J. B. W., Al-Mamgani, A., Tesseslaar, M. E. T., van den Brekel, M. W. M., Lange, C. A. H., van der Wal, J. E., Verheij, M., Zuur, C. L., & de Boer, J. P. (2020). Immuno-radiotherapy with cetuximab and avelumab for advanced stage head and neck squamous cell carcinoma: Results from a phase-I trial. Radiotherapy and oncology, 142, 79-84. https://doi.org/10.1016/j.radonc.2019.08.007
    • Essers, P. B. M., van der Heijden, M., Vossen, D., de Roest, R. H., Leemans, C. R., Brakenhoff, R. H., van den Brekel, M. W. M., Bartelink, H., Verheij, M., & Vens, C. (2020). Ovarian cancer-derived copy number alterations signatures are prognostic in chemoradiotherapy-treated head and neck squamous cell carcinoma. International journal of cancer, 147(6), 1732-1739. https://doi.org/10.1002/ijc.32962
    • Halpern, B. M., van Son, R., van den Brekel, M., & Scharenborg, O. (2020). Detecting and analysing spontaneous oral cancer speech in the wild. Proceedings of the Annual Conference of the International Speech Communication Association, INTERSPEECH, 21, 4826-4830. https://doi.org/10.21437/Interspeech.2020-1598 [details]
    • Karsten, R. T., van den Brekel, M. W. M., Smeele, L. E., Navran, A., Leary, S., Ingarfield, K., Pawlita, M., Waterboer, T., Thomas, S. J., & Ness, A. R. (2020). Patient-reported swallowing function after treatment for early-stage oropharyngeal carcinoma: Population-based study. Head & Neck, 42(8), 1981-1993. https://doi.org/10.1002/hed.26131
    • Karsten, R. T., van der Molen, L., Hamming-Vrieze, O., van Son, R. J. J. H., Hilgers, F. J. M., van den Brekel, M. W. M., Stuiver, M. M., & Smeele, L. E. (2020). Long-term swallowing, trismus, and speech outcomes after combined chemoradiotherapy and preventive rehabilitation for head and neck cancer; 10-year plus update. Head & Neck, 42(8), 1907-1918. https://doi.org/10.1002/hed.26120
    • Keek, S., Sanduleanu, S., Wesseling, F., De Roest, R., Van Den Brekel, M., Van Der Heijden, M., Vens, C., Giuseppina, C., Licitra, L., Scheckenbach, K., Vergeer, M., René Leemans, C., Brakenhoff, R. H., Nauta, I., Cavalieri, S., Woodruff, H. C., Poli, T., Leijenaar, R., Hoebers, F., & Lambin, P. (2020). Computed tomography-derived radiomic signature of head and neck squamous cell carcinoma (peri)tumoral tissue for the prediction of locoregional recurrence and distant metastasis after concurrent chemoradiotherapy. PLoS ONE, 15(5), [e0232639]. https://doi.org/10.1371/journal.pone.0232639
    • Leemans, M., van Sluis, K. E., van Son, R. J. J. H., & van den Brekel, M. W. M. (2020). Interaction of functional and participation issues on quality of life after total laryngectomy. Laryngoscope Investigative Otolaryngology, 5(3), 453-460. https://doi.org/10.1002/lio2.381 [details]
    • Marchi, F., Missale, F., Sampieri, C., Filauro, M., Iandelli, A., Parrinello, G., Incandela, F., Smeele, L. E., van den Brekel, M. W. M., Del Bon, F., Nicolai, P., Piazza, C., & Peretti, G. (2020). Laryngeal compartmentalization does not affect the prognosis of T3-T4 laryngeal cancer treated by upfront total laryngectomy. Cancers, 12(8), 1-18. [2241]. https://doi.org/10.3390/cancers12082241
    • Nabuurs, C. H., Kievit, W., Labbé, N., Leemans, C. R., Smit, C. F. G. M., van den Brekel, M. W. M., Pauw, R. J., van der Laan, B. F. A. M., Jansen, J. C., Lacko, M., Braunius, W. W., Morita, S., Wierzbicka, M., Matoba, T., Hanai, N., Takes, R. P., & Kunst, H. P. M. (2020). Evaluation of the modified Pittsburgh classification for predicting the disease-free survival outcome of squamous cell carcinoma of the external auditory canal. Head and Neck, 42(12), 3609-3622. https://doi.org/10.1002/hed.26424
    • Van der Laaken, M., Bannink, A., & Van den Brekel, M. (2020). Topicalizing psychosocial distress in cancer follow-up consultations: An exploration of the interactional effects of discussion tools. Cogent Arts & Humanities, 7, [1812866]. https://doi.org/10.1080/23311983.2020.1812866 [details]
    • de Veij Mestdagh, P. D., Walraven, I., Vogel, W. V., Schreuder, W. H., van Werkhoven, E., Carbaat, C., Donswijk, M. L., van den Brekel, M. W. M., & Al-Mamgani, A. (2020). SPECT/CT-guided elective nodal irradiation for head and neck cancer is oncologically safe and less toxic: A potentially practice-changing approach. Radiotherapy and oncology, 147, 56-63. https://doi.org/10.1016/j.radonc.2020.03.012
    • van Sluis, K. E., Kornman, A. F., Groen, W. G., van den Brekel, M. W. M., van der Molen, L., Hoffman-Ruddy, B., & Stuiver, M. M. (2020). Expiratory Muscle Strength Training in patients After Total Laryngectomy; A Feasibility Pilot Study. The Annals of Otology Rhinology & Laryngology, 129(12), 1186-1194. https://doi.org/10.1177/0003489420931889 [details]
    • van Sluis, K. E., Kornman, A. F., van der Molen, L., van den Brekel, M. W. M., & Yaron, G. (2020). Women's perspective on life after total laryngectomy: a qualitative study. International Journal of Language and Communication Disorders, 55(2), 188-199. https://doi.org/10.1111/1460-6984.12511 [details]
    • van der Heijden, M., Essers, P. B. M., Verhagen, C. V. M., Willems, S. M., Sanders, J., de Roest, R. H., Vossen, D. M., Leemans, C. R., Verheij, M., Brakenhoff, R. H., van den Brekel, M. W. M., & Vens, C. (2020). Epithelial-to-mesenchymal transition is a prognostic marker for patient outcome in advanced stage HNSCC patients treated with chemoradiotherapy. Radiotherapy and oncology, 147, 186-194. https://doi.org/10.1016/j.radonc.2020.05.013
    • van der Heijden, M., Essers, P. B. M., de Jong, M. C., de Roest, R. H., Sanduleanu, S., Verhagen, C. V. M., Hamming-Vrieze, O., Hoebers, F., Lambin, P., Bartelink, H., Leemans, C. R., Verheij, M., Brakenhoff, R. H., van den Brekel, M. W. M., & Vens, C. (2020). Biological Determinants of Chemo-Radiotherapy Response in HPV-Negative Head and Neck Cancer: A Multicentric External Validation. Frontiers in Oncology, 9, [1470]. https://doi.org/10.3389/fonc.2019.01470

    2019

    • Beck, A-JCC., Passchier, E., Retèl, V. P., Stuiver, M. M., van der Molen, L., Klop, W. M. C., Navran, A., van Harten, W. H., & van den Brekel, M. W. M. (2019). Study protocol of a prospective multicenter study comparing (cost-)effectiveness of a tailored interdisciplinary head and neck rehabilitation program to usual supportive care for patients treated with concomitant chemo- or bioradiotherapy. BMC Cancer, 19, [655]. https://doi.org/10.1186/s12885-019-5874-z [details]
    • Beck, A. C. C., Retèl, V. P., Bhairosing, P. A., van den Brekel, M. W. M., & van Harten, W. H. (2019). Barriers and facilitators of patient access to medical devices in Europe: A systematic literature review. Health Policy, 123(12), 1185-1198. https://doi.org/10.1016/j.healthpol.2019.10.002
    • Beck, A. C. C., Retèl, V. P., van den Brekel, M. W. M., & van Harten, W. H. (2019). Patient access to voice prostheses and heat and moisture exchangers: Factors influencing physician's prescription and reimbursement in eight European countries. Oral Oncology, 91, 56-64. https://doi.org/10.1016/j.oraloncology.2019.02.017 [details]
    • Beck, A. J. C. C., Kieffer, J. M., Retèl, V. P., van Overveld, L. F. J., Takes, R. P., van den Brekel, M. W. M., van Harten, W. H., & Stuiver, M. M. (2019). Mapping the EORTC QLQ-C30 and QLQ-H&N35 to the EQ-5D for head and neck cancer: Can disease-specific utilities be obtained? PLoS ONE, 14(12), [e0226077]. https://doi.org/10.1371/journal.pone.0226077
    • De Haan, R., Van Werkhoven, E., Van Den Heuvel, M. M., Peulen, H. M. U., Sonke, G. S., Elkhuizen, P., Van Den Brekel, M. W. M., Tesselaar, M. E. T., Vens, C., Schellens, J. H. M., Van Triest, B., & Verheij, M. (2019). Study protocols of three parallel phase 1 trials combining radical radiotherapy with the PARP inhibitor olaparib. BMC Cancer, 19(1), [901]. https://doi.org/10.1186/s12885-019-6121-3
    • De Veij Mestdagh, P. D., Schreuder, W. H., Vogel, W. V., Donswijk, M. L., Van Werkhoven, E., Van Der Wal, J. E., Dirven, R., Karakullukcu, B., Sonke, J. J., Van Den Brekel, M. W. M., Marijnen, C. A. M., & Al-Mamgani, A. (2019). Mapping of sentinel lymph node drainage using SPECT/CT to tailor elective nodal irradiation in head and neck cancer patients (SUSPECT-2): a single-center prospective trial. BMC Cancer, 19(1), [1110]. https://doi.org/10.1186/s12885-019-6331-8
    • Elbers, J. B. W., Al-Mamgani, A., van den Brekel, M. W. M., Jóźwiak, K., de Boer, J. P., Lohuis, P. J. F. M., Willems, S. M., Verheij, M., & Zuur, C. L. (2019). Salvage surgery for recurrence after radiotherapy for squamous cell carcinoma of the head and neck. Otolaryngology-Head and Neck Surgery, 160(6), 1023-1033. https://doi.org/10.1177/0194599818818443 [details]
    • Elbers, J. B. W., Veldhuis, L. I., Bhairosing, P. A., Smeele, L. E., Jóźwiak, K., van den Brekel, M. W. M., ... Zuur, C. L. (2019). Salvage surgery for advanced stage head and neck squamous cell carcinoma following radiotherapy or chemoradiation. European Archives of Oto-Rhino-Laryngology, 276(3), 647-655. https://doi.org/10.1007/s00405-019-05292-0 [details]
    • Essers, P. B. M., Van Der Heijden, M., Verhagen, C. V. M., Ploeg, E. M., De Roest, R. H., Leemans, C. R., Brakenhoff, R. H., Van Den Brekel, M. W. M., Bartelink, H., Verheij, M., & Vens, C. (2019). Drug sensitivity prediction models reveal a link between DNA repair defects and poor prognosis in HNSCC. Cancer Research, 79(21), 5597-5611. https://doi.org/10.1158/0008-5472.CAN-18-3388
    • Karsten, R. T., Al-Mamgani, A., Bril, S. I., Tjon-A-Joe, S., van der Molen, L., de Boer, J. P., Hilgers, F. J. M., Smeele, L. E., van den Brekel, M. W. M., & Stuiver, M. M. (2019). Sarcopenia, a strong determinant for prolonged feeding tube dependency after chemoradiotherapy for head and neck cancer. Head and Neck, 41(11), 4000-4008. https://doi.org/10.1002/hed.25938 [details]
    • Kraaijenga, S. A., Hamming-Vrieze, O., Verheijen, S., Lamers, E., van der Molen, L., Hilgers, F. J., van den Brekel, M. W., & Heemsbergen, W. D. (2019). Radiation dose to the masseter and medial pterygoid muscle in relation to trismus after chemoradiotherapy for advanced head and neck cancer. Head and Neck, 41(5), 1387-1394. https://doi.org/10.1002/hed.25573
    • Navran, A., Heemsbergen, W. D., Janssen, T., Hamming-Vrieze, O., Jonker, M., Zuur, C., Verheij, M., Remeijer, P., Sonke, J. J., van den Brekel, M., & Al-Mamgani, A. (2019). The impact of margin reduction on outcome and toxicity in head and neck cancer patients treated with image-guided volumetric modulated arc therapy (VMAT). Radiotherapy and oncology, 130, 25-31. https://doi.org/10.1016/j.radonc.2018.06.032
    • Petersen, J. F., Arends, C. R., van der Noort, V., Al-Mamgani, A., de Boer, J. P., Stuiver, M. M., & van den Brekel, M. W. M. (2019). Laryngo-esophageal dysfunction free survival and propensity score matched analysis comparing organ preservation and total laryngectomy in hypopharynx cancer. Oral Oncology, 95, 143-149. https://doi.org/10.1016/j.oraloncology.2019.06.018
    • Petersen, J. F., Berlanga, A., Stuiver, M. M., Hamming-Vrieze, O., Hoebers, F., Lambin, P., & van den Brekel, M. W. M. (2019). Improving decision making in larynx cancer by developing a decision aid: A mixed methods approach. Laryngoscope, 129(12), 2733-2739. https://doi.org/10.1002/lary.27800
    • Petersen, J. F., Lansaat, L., Hilgers, F., & van den Brekel, M. (2019). Solving periprosthetic leakage with a novel prosthetic device. Laryngoscope, 129(10), 2299-2302. https://doi.org/10.1002/lary.27645
    • Petersen, J. F., Lansaat, L., Timmermans, A. J., van der Noort, V., Hilgers, F. J. M., & van den Brekel, M. W. M. (2019). Postlaryngectomy prosthetic voice rehabilitation outcomes in a consecutive cohort of 232 patients over a 13-year period. Head & Neck, 41(3), 623-631. https://doi.org/10.1002/hed.25364 [details]
    • Petersen, J. F., Pézier, T. F., van Dieren, J. M., van der Noort, V., van Putten, T., Bril, S. I., Janssen, L., Dirven, R., van den Brekel, M. W. M., & de Bree, R. (2019). Dilation after laryngectomy: Incidence, risk factors and complications. Oral Oncology, 91, 107-112. https://doi.org/10.1016/j.oraloncology.2019.02.025
    • Ratnayake, C. B. B., Fles, R., Tan, I. B., Baijens, L. W. J., Pilz, W., Meeuwis, C. A., Janssen-van Det, P. H. E., van Son, R., & Van den Brekel, M. W. M. (2019). Multicenter randomized crossover trial evaluating the provox luna in laryngectomized subjects. Laryngoscope, 129(10), 2354-2360. https://doi.org/10.1002/lary.27839
    • Vaarwerk, B., Hol, M. L. F., Schoot, R. A., Breunis, W. B., de Win, M. M. L., Westerveld, H., Fajardo, R. D., Saeed, P., van den Brekel, M. W., Pieters, B. R., Strackee, S. D., Smeele, L. E., & Merks, J. H. M. (2019). AMORE treatment as salvage treatment in children and young adults with relapsed head-neck rhabdomyosarcoma. Radiotherapy and oncology, 131, 21-26. https://doi.org/10.1016/j.radonc.2018.10.036
    • Vaarwerk, B., Schoot, R. A., Maurice-Stam, H., Slater, O., Hartley, B., Saeed, P., Gajdosova, E., van den Brekel, M. W., Balm, A. J. M., Hol, M. L. F., van Jaarsveld, S., Kremer, L. C. M., Ronckers, C. M., Mandeville, H. C., Pieters, B. R., Gaze, M. N., Davila Fajardo, R., Strackee, S. D., Dunaway, D., ... Merks, J. H. M. (2019). Psychosocial well-being of long-term survivors of pediatric head-neck rhabdomyosarcoma. Pediatric Blood & Cancer, 66(2), [e27498]. https://doi.org/10.1002/pbc.27498 [details]
    • Van Der Heijden, M., De Jong, M. C., Verhagen, C. V. M., De Roest, R. H., Sanduleanu, S., Hoebers, F., Leemans, C. R., Brakenhoff, R. H., Vens, C., Verheij, M., & Van Den Brekel, M. W. M. (2019). Acute hypoxia profile is a stronger prognostic factor than chronic hypoxia in advanced stage head and neck cancer patients. Cancers, 11(4), [583]. https://doi.org/10.3390/CANCERS11040583
    • Vossen, D. M., Verhagen, C. V. M., Van Der Heijden, M., Essers, P. B. M., Bartelink, H., Verheij, M., Wessels, L. F. A., Van Den Brekel, M. W. M., & Vens, C. (2019). Genetic factors associated with a poor outcome in head and neck cancer patients receiving definitive chemoradiotherapy. Cancers, 11(4), [445]. https://doi.org/10.3390/cancers11040445
    • Willems, S. M., Abeln, S., Feenstra, K. A., de Bree, R., van der Poel, E. F., Baatenburg de Jong, R. J., Heringa, J., & van den Brekel, M. W. M. (2019). The potential use of big data in oncology. Oral Oncology, 98, 8-12. https://doi.org/10.1016/j.oraloncology.2019.09.003
    • de Ridder, M., Gouw, Z. A. R., Navran, A., Hamming-Vrieze, O., Jasperse, B., van den Brekel, M. W. M., Vogel, W. V., & Al-Mamgani, A. (2019). FDG-PET/CT improves detection of residual disease and reduces the need for examination under anaesthesia in oropharyngeal cancer patients treated with (chemo-)radiation. European Archives of Oto-Rhino-Laryngology, 276(5), 1447-1455. https://doi.org/10.1007/s00405-019-05340-9

    2018

    • Boon, E., Bel, M., van Boxtel, W., van der Graaf, W. T. A., van Es, R. J. J., Eerenstein, S. E. J., Baatenburg de Jong, R. J., van den Brekel, M. W. M., van der Velden, L-A., Witjes, M. J. H., Hoeben, A., Willems, S. M., Bloemena, E., Smit, L. A., Oosting, S. F., PALGA Group, Jonker, M. A., Flucke, U. E., & van Herpen, C. M. L. (2018). A clinicopathological study and prognostic factor analysis of 177 salivary duct carcinoma patients from The Netherlands. International journal of cancer, 143(4), 758-766. https://doi.org/10.1002/ijc.31353 [details]
    • Buffart, L. M., de Bree, R., Altena, M., van der Werff, S., Drossaert, C., Speksnijder, C. M., van den Brekel, M. W., Jager-Wittenaar, H., Aaronson, N. K., & Stuiver, M. M. (2018). Demographic, clinical, lifestyle-related, and social-cognitive correlates of physical activity in head and neck cancer survivors. Supportive Care in Cancer, 26(5), 1447–1456. https://doi.org/10.1007/s00520-017-3966-3
    • Dohmen, A. J. C., Sanders, J., Canisius, S., Jordanova, E. S., Aalbersberg, E. A., van den Brekel, M. W. M., Neefjes, J., & Zuur, C. L. (2018). Sponge-supported cultures of primary head and neck tumors for an optimized preclinical model. Oncotarget, 9(38), 25034-25047. https://doi.org/10.18632/oncotarget.25244 [details]
    • Gouw, Z. A. R., de Boer, J. P., Navran, A., van den Brekel, M. W. M., Sonke, J. J., & Al-Mamgani, A. (2018). Baseline peripheral blood leukocytosis: Biological marker predicts outcome in oropharyngeal cancer, regardless of HPV-status. Oral Oncology, 78, 200-206. https://doi.org/10.1016/j.oraloncology.2018.02.003 [details]
    • Karsten, R. T., Timmermans, A. J., ten Cate, J., Stuiver, M. M., & van den Brekel, M. W. M. (2018). Direct complications and routine ICU admission after total laryngectomy. Acta Oto-Laryngologica, 138(12), 1128-1135. https://doi.org/10.1080/00016489.2018.1515497
    • Kleijn, G., Lissenberg-Witte, B. I., Bohlmeijer, E. T., Steunenberg, B., Knipscheer-Kuijpers, K., Willemsen, V., Becker, A., Smit, E. F., Eeltink, C. M., Bruynzeel, A. M. E., van der Vorst, M., de Bree, R., René Leemans, C., van den Brekel, M. W. M., Cuijpers, P., & Verdonck-de Leeuw, I. M. (2018). The efficacy of Life Review Therapy combined with Memory Specificity Training (LRT-MST) targeting cancer patients in palliative care: A randomized controlled trial. PLoS ONE, 13(5), [e0197277]. https://doi.org/10.1371/journal.pone.0197277
    • Langhout, G. C., Kuhlmann, K. F. D., Schreuder, P., Bydlon, T., Smeele, L. E., van den Brekel, M. W. M., Sterenborg, H. J. C. M., Hendriks, B. H. W., & Ruers, T. J. M. (2018). In vivo nerve identification in head and neck surgery using diffuse reflectance spectroscopy. Laryngoscope Investigative Otolaryngology, 3(5), 349-355. https://doi.org/10.1002/lio2.174
    • Lansaat, L., de Kleijn, B., Hilgers, F., van der Laan, B., & van den Brekel, M. (2018). Comparative Study Between Peristomal Patches in Patients with Definitive Tracheostomy. International Archives of Otorhinolaryngology, 22(2), 130-135. https://doi.org/10.1055/s-0037-1603921 [details]
    • Lansaat, L., van der Noort, V., Bernard, S. E., Eerenstein, S. E. J., Plaat, B. E. C., Langeveld, T. A. P. M., Lacko, M., Hilgers, F. J. M., de Bree, R., Takes, R. P., van den Brekel, M. W. M., & Dutch Head and Neck Society (2018). Predictive factors for pharyngocutaneous fistulization after total laryngectomy: a Dutch Head and Neck Society audit. European Archives of Oto-Rhino-Laryngology, 275(3), 783-794. https://doi.org/10.1007/s00405-017-4861-8 [details]
    • Petersen, J. F., Stuiver, M. M., Timmermans, A. J., Chen, A., Zhang, H., O'Neill, J. P., Deady, S., Vander Poorten, V., Meulemans, J., Wennerberg, J., Skroder, C., Day, A. T., Koch, W., & van den Brekel, M. W. M. (2018). Development and external validation of a risk-prediction model to predict 5-year overall survival in advanced larynx cancer. The Laryngoscope, 128(5), 1140-1145. https://doi.org/10.1002/lary.26990 [details]
    • Petersen, J. F., Timmermans, A. J., van Dijk, B. A. C., Overbeek, L. I. H., Smit, L. A., Hilgers, F. J. M., Stuiver, M. M., & van den Brekel, M. W. M. (2018). Trends in treatment, incidence and survival of hypopharynx cancer: a 20-year population-based study in the Netherlands. European Archives of Oto-Rhino-Laryngology, 275(1), 181-189. https://doi.org/10.1007/s00405-017-4766-6 [details]
    • Verhagen, C. V. M., Vossen, D. M., Borgmann, K., Hageman, F., Grénman, R., Verwijs-Jansen, M., Mout, L., Kluin, R. J. C., Nieuwland, M., Severson, T. M., Velds, A., Kerkhoven, R., O'Connor, M. J., van der Heijden, M., van Velthuysen, M-L., Verheij, M., Wreesmann, V. B., Wessels, L. F. A., van den Brekel, M. W. M., & Vens, C. (2018). Fanconi anemia and homologous recombination gene variants are associated with functional DNA repair defects in vitro and poor outcome in patients with advanced head and neck squamous cell carcinoma. Oncotarget, 9(26), 18198-18213. https://doi.org/10.18632/oncotarget.24797 [details]
    • Vossen, D. M., Verhagen, C. V. M., Grénman, R., Kluin, R. J. C., Verheij, M., van den Brekel, M. W. M., Wessels, L. F. A., & Vens, C. (2018). Role of variant allele fraction and rare SNP filtering to improve cellular DNA repair endpoint association. PLoS ONE, 13(11), [e0206632]. https://doi.org/10.1371/journal.pone.0206632 [details]
    • Vossen, D. M., Verhagen, C. V. M., Verheij, M., Wessels, L. F. A., Vens, C., & van den Brekel, M. W. M. (2018). Comparative genomic analysis of oral versus laryngeal and pharyngeal cancer. Oral Oncology, 81, 35-44. https://doi.org/10.1016/j.oraloncology.2018.04.006 [details]
    • van Sluis, K. E., van der Molen, L., van Son, R. J. J. H., Hilgers, F. J. M., Bhairosing, P. A., & van den Brekel, M. W. M. (2018). Objective and subjective voice outcomes after total laryngectomy: a systematic review. European Archives of Oto-Rhino-Laryngology, 275(1), 11-26. https://doi.org/10.1007/s00405-017-4790-6 [details]

    2017

    • Al-Mamgani, A., Verheij, M., & van den Brekel, M. W. M. (2017). Elective unilateral nodal irradiation in head and neck squamous cell carcinoma: A paradigm shift. European Journal of Cancer, 82, 1-5. https://doi.org/10.1016/j.ejca.2017.05.035 [details]
    • De Bree, R., Willems, S. M., Janssen, L. M., & Van Den Brekel, M. W. M. (2017). Doorsnijden van tumor bij hoofd-halskanker: een taboe? Nederlands Tijdschrift voor Geneeskunde, 161(46).
    • Dohmen, A. J. C., Qiao, X., Duursma, A., Wijdeven, R. H., Lieftink, C., Hageman, F., Morris, B., Halonen, P., Vens, C., van den Brekel, M. W. M., Ovaa, H., Neefjes, J., & Zuur, C. L. (2017). Identification of a novel ATM inhibitor with cancer cell specific radiosensitization activity. Oncotarget, 8(43), 73925-73937. https://doi.org/10.18632/oncotarget.18034 [details]
    • Duinkerken, C. W., Lohuis, P. J. F. M., Crijns, M. B., Navran, A., Haas, R. L. M., Hamming-Vrieze, O., Klop, W. M. C., van den Brekel, M. W. M., & Al-Mamgani, A. (2017). Orthovoltage X-rays for postoperative treatment of resected basal cell carcinoma in the head and neck area. Journal of cutaneous medicine and surgery, 21(3), 243-249. https://doi.org/10.1177/1203475416687268
    • Elbers, J. B. W., Al-Mamgani, A., Paping, D., van den Brekel, M. W. M., Jóźwiak, K., de Boer, J. P., Karakullukcu, B., Verheij, M., & Zuur, C. L. (2017). Definitive (chemo)radiotherapy is a curative alternative for standard of care in advanced stage squamous cell carcinoma of the oral cavity. Oral Oncology, 75, 163-168. https://doi.org/10.1016/j.oraloncology.2017.11.006 [details]
    • Gouw, Z. A. R., Jasperse, B., Sonke, J. J., Heemsbergen, W. D., Navran, A., Hamming-Vrieze, O., Paul de Boer, J., van den Brekel, M. W. M., & Al-Mamgani, A. (2017). A predictive model for residual disease after (chemo) radiotherapy in oropharyngeal carcinoma: Combined radiological and clinical evaluation of tumor response. Clinical and Translational Radiation Oncology, 6, 1-6. https://doi.org/10.1016/j.ctro.2017.07.002
    • Hamming-Vrieze, O., van Kranen, S. R., Heemsbergen, W. D., Lange, C. A. H., van den Brekel, M. W. M., Verheij, M., Rasch, C. R. N., & Sonke, J. J. (2017). Analysis of GTV reduction during radiotherapy for oropharyngeal cancer: Implications for adaptive radiotherapy. Radiotherapy and oncology, 122(2), 224-228. https://doi.org/10.1016/j.radonc.2016.10.012
    • Kraaijenga, S. A. C., van der Molen, L., Heemsbergen, W. D., Remmerswaal, G. B., Hilgers, F. J. M., & van den Brekel, M. W. M. (2017). Hyoid bone displacement as parameter for swallowing impairment in patients treated for advanced head and neck cancer. European Archives of Oto-Rhino-Laryngology, 274(2), 597-606. https://doi.org/10.1007/s00405-016-4029-y [details]
    • Kraaijenga, S. A. C., van der Molen, L., Stuiver, M. M., Takes, R. P., Al-Mamgani, A., van den Brekel, M. W. M., & Hilgers, F. J. M. (2017). Efficacy of a novel swallowing exercise program for chronic dysphagia in long-term head and neck cancer survivors. Head & Neck, 39(10), 1943-1961. https://doi.org/10.1002/hed.24710 [details]
    • Lansaat, L., de Kleijn, B. J., Hilgers, F. J. M., van der Laan, B. F. A. M., & van den Brekel, M. W. M. (2017). A prospective multicenter clinical feasibility study of a new automatic speaking valve for postlaryngectomy voice rehabilitation. European Archives of Oto-Rhino-Laryngology, 274(2), 1005-1013. https://doi.org/10.1007/s00405-016-4304-y [details]
    • Lansaat, L., van den Boer, C., Muller, S. H., van der Noort, V., van den Brekel, M. W. M., & Hilgers, F. J. M. (2017). Ex vivo humidifying capacity and patient acceptability of stoma cloths in laryngectomized individuals. Head & Neck, 39(5), 921-931. https://doi.org/10.1002/hed.24708 [details]
    • Leemans, M., van Alphen, M. J. A., van den Brekel, M. W. M., & Hekman, E. E. G. (2017). Analysis of tracheostoma morphology. Acta Oto-Laryngologica, 137(9), 997-1001. https://doi.org/10.1080/00016489.2017.1306880
    • Yaron, G., Meershoek, A., Widdershoven, G., van den Brekel, M., & Slatman, J. (2017). Facing a Disruptive Face: Embodiment in the Everyday Experiences of “Disfigured” Individuals. Human Studies, 40(2), 285-307. https://doi.org/10.1007/s10746-017-9426-8
    • de Ridder, M., Gouw, Z. A. R., Sonke, J. J., Navran, A., Jasperse, B., Heukelom, J., Tesselaar, M. E. T., Klop, W. M. C., van den Brekel, M. W. M., & Al-Mamgani, A. (2017). Recurrent oropharyngeal cancer after organ preserving treatment: pattern of failure and survival. European Archives of Oto-Rhino-Laryngology, 274(3), 1691-1700. https://doi.org/10.1007/s00405-016-4413-7
    • de Ridder, M., Klop, M., Hamming-Vrieze, O., de Boer, J. P., Jasperse, B., Smit, L., Vogel, W., van den Brekel, M., & Al-Mamgani, A. (2017). Unknown primary head and neck squamous cell carcinoma in the era of fluorodeoxyglucose-positron emission tomography/CT and intensity-modulated radiotherapy. Head & Neck, 39(7), 1382-1391. https://doi.org/10.1002/hed.24762 [details]

    2016

    • Clapham, R. P., Martens, J-P., van Son, R. J. J. H., Hilgers, F. J. M., van den Brekel, M. W. M., & Middag, C. (2016). Computing scores of voice quality and speech intelligibility in tracheoesophageal speech for speech stimuli of varying lengths. Computer Speech and Language, 37, 1-10. https://doi.org/10.1016/j.csl.2015.10.001 [details]
    • Clement, S. C., Schoot, R. A., Slater, O., Chisholm, J. C., Abela, C., Balm, A. J. M., Van Den Brekel, M. W., Breunis, W. B., Chang, Y. C., Davila Fajardo, R., Dunaway, D., Gajdosova, E., Gaze, M. N., Gupta, S., Hartley, B., Kremer, L. C. M., Van Lennep, M., Levitt, G. A., Mandeville, H. C., ... Merks, J. H. M. (2016). Endocrine disorders among long-term survivors of childhood head and neck rhabdomyosarcoma. European Journal of Cancer, 54, 1-10. https://doi.org/10.1016/j.ejca.2015.10.064
    • Jacobi, I., Navran, A., van der Molen, L., Heemsbergen, W. D., Hilgers, F. J. M., & van den Brekel, M. W. M. (2016). Radiation dose to the tongue and velopharynx predicts acoustic-articulatory changes after chemo-IMRT treatment for advanced head and neck cancer. European Archives of Oto-Rhino-Laryngology, 273(2), 487-494. https://doi.org/10.1007/s00405-015-3526-8 [details]
    • Jacobi, I., Timmermans, A. J., Hilgers, F. J. M., & van den Brekel, M. W. M. (2016). Voice quality and surgical detail in post-laryngectomy tracheoesophageal speakers. European Archives of Oto-Rhino-Laryngology, 273(9), 2669-2679. https://doi.org/10.1007/s00405-015-3777-4 [details]
    • Kraaijenga, S. A. C., Lapid, O., van der Molen, L., Hilgers, F. J. M., Smeele, L. E., & van den Brekel, M. W. M. (2016). Feasibility and potential value of lipofilling in post-treatment oropharyngeal dysfunction. The Laryngoscope, 126(12), 2672-2678. https://doi.org/10.1002/lary.26003 [details]
    • Kraaijenga, S. A. C., Oskam, I. M., van Son, R. J. J. H., Hamming-Vrieze, O., Hilgers, F. J. M., van den Brekel, M. W. M., & van der Molen, L. (2016). Assessment of voice, speech, and related quality of life in advanced head and neck cancer patients 10-years+ after chemoradiotherapy. Oral Oncology, 55, 24-30. https://doi.org/10.1016/j.oraloncology.2016.02.001 [details]
    • Passchier, E., Stuiver, M. M., van der Molen, L., Kerkhof, S. I. C., van den Brekel, M. W. M., & Hilgers, F. J. M. (2016). Feasibility and impact of a dedicated multidisciplinary rehabilitation program on health-related quality of life in advanced head and neck cancer patients. European Archives of Oto-Rhino-Laryngology, 273(6), 1577-1587. https://doi.org/10.1007/s00405-015-3648-z [details]
    • Rebers, S., Vermeulen, E., Brandenburg, A. P., Stoof, T. J., Zupan-Kajcovski , B., Bos, W. J. W., Jonker, M. J., Bax, C. J., van Driel, W. J., Verwaal, V. J., van den Brekel, M. W., Grutters, J. C., Tupker, R. A., Plusjé, L., de Bree, R., Schagen van Leeuwen, J. H., Vermeulen, E. G. J., de Leeuw, R. A., Brohet, R. M., ... Schmidt, M. K. (2016). A randomised controlled trial of consent procedures for the use of residual tissues for medical research: Preferences of and implications for patients, research and clinical practice. PLoS ONE, 11(3), [e0152509]. https://doi.org/10.1371/journal.pone.0152509 [details]
    • Samuels, S. E., Eisbruch, A., Beitler, J. J., Corry, J., Bradford, C. R., Saba, N. F., van den Brekel, M. W. M., Smee, R., Strojan, P., Suarez, C., Mendenhall, W. M., Takes, R. P., Rodrigo, J. P., Haigentz, M., Rapidis, A. D., Rinaldo, A., & Ferlito, A. (2016). Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: Where are we? European Archives of Oto-Rhino-Laryngology, 273(10), 2877-2894. https://doi.org/10.1007/s00405-015-3771-x [details]
    • Timmer, F. C. A., Klop, W. M. C., Relyveld, G. N., Crijns, M. B., Balm, A. J. M., van den Brekel, M. W. M., & Lohuis, P. J. F. M. (2016). Merkel cell carcinoma of the head and neck: emphasizing the risk of undertreatment. European Archives of Oto-Rhino-Laryngology, 273(5), 1243-1251. https://doi.org/10.1007/s00405-015-3558-0 [details]
    • Timmermans, A. J., Harmsen, H. J. M., Bus-Spoor, C., Buijssen, K. J. D. A., van As-Brooks, C., de Goffau, M. C., Tonk, R. H., van den Brekel, M. W. M., Hilgers, F. J. M., & van der Laan, B. F. A. M. (2016). Biofilm formation on the Provox ActiValve: Composition and ingrowth analyzed by Illumina paired-end RNA sequencing, fluorescence in situ hybridization, and confocal laser scanning microscopy. Head & Neck, 38(S1), E432-E440. https://doi.org/10.1002/hed.24014 [details]
    • Timmermans, A. J., Lange, C. A. H., de Bois, J. A., van Werkhoven, E., Hamming-Vrieze, O., Hilgers, F. J. M., & van den Brekel, M. W. M. (2016). Tumor volume as a prognostic factor for local control and overall survival in advanced larynx cancer. The Laryngoscope, 126(2), E60-E67. https://doi.org/10.1002/lary.25567 [details]
    • Timmermans, A. J., van Dijk, B. A. C., Overbeek, L. I. H., Velthuysen, M-LF., van Tinteren, H., Hilgers, F. J. M., & van den Brekel, M. W. M. (2016). Trends in treatment and survival for advanced laryngeal cancer: a 20-year population-based study in The Netherlands. Head & Neck, 38(S1), E1247-E1255. https://doi.org/10.1002/hed.24200 [details]
    • Wondergem, M., Lieben, G., Bouman, S., van den Brekel, M. W. M., & Lohuis, P. J. F. M. (2016). Patients' satisfaction with facial prostheses. British Journal of Oral & Maxillofacial Surgery, 54(4), 394-399. https://doi.org/10.1016/j.bjoms.2015.09.011 [details]
    • Zuur, C. L., Dohmen, A. J. C., van den Brekel, M. W., Wang, X. J., & Malkosky, S. (2016). Preclinical models of head and neck squamous cell carcinoma. In Head and Neck Cancer: Multimodality Management, Second Edition (pp. 205-213). Springer International Publishing. https://doi.org/10.1007/978-3-319-27601-4_10
    • de Bree, R., van der Putten, L., van Tinteren, H., Wedman, J., Oyen, W. J. G., Janssen, L. M., van den Brekel, M. W. M., Comans, E. F. I., Pruim, J., Takes, R. P., Hobbelink, M. G. G., Valdés Olmos, R., van der Laan, B. F. A. M., Boers, M., Hoekstra, O. S., & Leemans, C. R. (2016). Effectiveness of an 18F-FDG-PET based strategy to optimize the diagnostic trajectory of suspected recurrent laryngeal carcinoma after radiotherapy: The RELAPS multicenter randomized trial. Radiotherapy and oncology, 118(2), 251-256. https://doi.org/10.1016/j.radonc.2015.10.010 [details]
    • de Ridder, M., Marres, C. C. M., Smeele, L. E., van den Brekel, M. W. M., Hauptmann, M., Balm, A. J. M., & van Velthuysen, M. L. F. (2016). A critical evaluation of lymph node ratio in head and neck cancer. Virchows Archiv, 469(6), 635-641. https://doi.org/10.1007/s00428-016-2015-9
    • van Monsjou, H. S., Schaapveld, M., Hamming-Vrieze, O., de Boer, J. P., van den Brekel, M. W. M., & Balm, A. J. M. (2016). Cause-specific excess mortality in patients treated for cancer of the oral cavity and oropharynx: a population-based study. Oral Oncology, 52, 37-44. https://doi.org/10.1016/j.oraloncology.2015.10.013 [details]
    • van Sluis, K. E., van den Brekel, M. W. M., Hilgers, F. J. M., & van Son, R. J. J. H. (2016). Long-Term Stability of Tracheoesophageal Voices. Interspeech, 17, 102-116. https://doi.org/10.21437/Interspeech.2016-114 [details]

    2015

    • Clapham, R. P., van As-Brooks, C. J., van Son, R. J. J. H., Hilgers, F. J. M., & van den Brekel, M. W. M. (2015). The Relationship Between Acoustic Signal Typing and Perceptual Evaluation of Tracheoesophageal Voice Quality for Sustained Vowels. Journal of Voice, 29(4), 517.e23-517.e29. https://doi.org/10.1016/j.jvoice.2014.10.002 [details]
    • Dohmen, A. J. C., Swartz, J. E., Van Den Brekel, M. W. M., Willems, S. M., Spijker, R., Neefjes, J., & Zuur, C. L. (2015). Feasibility of primary tumor culture models and preclinical prediction assays for head and neck cancer: A narrative review. Cancers, 7(3), 1716-1742. https://doi.org/10.3390/cancers7030858 [details]
    • Henneman, R., van Monsjou, H. S., Verhagen, C. V. M., van Velthuysen, M-LF., ter Haar, N. T., Osse, E. M., Lopes-Yurda, M. I., Balm, A. J. M., & van den Brekel, M. W. M. (2015). Incidence Changes of Human Papillomavirus in Oropharyngeal Squamous Cell Carcinoma and Effects on Survival in the Netherlands Cancer Institute, 1980-2009. Anticancer research, 35(7), 4015-4022. http://ar.iiarjournals.org/content/35/7/4015.abstract [details]
    • Hilgers, F. J. M., Dirven, R., Jacobi, I., & van den Brekel, M. W. M. (2015). Physiology and prospects of bimanual tracheoesophageal brass instrument play. Acta Otorhinolaryngologica Italica, 35(3), 202-207. http://www.actaitalica.it/issues/2015/3-2015/10%20Hilgers-ABS.html [details]
    • Kraaijenga, S. A. C., Oskam, I. M., van der Molen, L., Hamming-Vrieze, O., Hilgers, F. J. M., & van den Brekel, M. W. M. (2015). Evaluation of long term (10-years+) dysphagia and trismus in patients treated with concurrent chemo-radiotherapy for advanced head and neck cancer. Oral Oncology, 51(8), 787-794. https://doi.org/10.1016/j.oraloncology.2015.05.003 [details]
    • Kraaijenga, S. A. C., van der Molen, L., Jacobi, I., Hamming-Vrieze, O., Hilgers, F. J. M., & van den Brekel, M. W. M. (2015). Prospective clinical study on long-term swallowing function and voice quality in advanced head and neck cancer patients treated with concurrent chemoradiotherapy and preventive swallowing exercises. European Archives of Oto-Rhino-Laryngology, 272(11), 3521-3531. https://doi.org/10.1007/s00405-014-3379-6 [details]
    • Kraaijenga, S. A. C., van der Molen, L., Stuiver, M. M., Teertstra, H. J., Hilgers, F. J. M., & van den Brekel, M. (2015). Effects of strengthening exercises on swallowing musculature and function in senior healthy subjects; a prospective effectiveness and feasibility study. Dysphagia, 30(4), 392-403. https://doi.org/10.1007/s00455-015-9611-8 [details]
    • Lodder, W. L., Vogel, W. V., Lange, C. A., Hamming-Vrieze, O., van Velthuysen, M. L., Pameijer, F. A., Balm, A. J., & van den Brekel, M. W. (2015). Detection of extranodal spread in head and neck cancer with [18F]FDG PET and MRI: improved accuracy? The Quarterly Journal of Nuclear Medicine and Molecular Imaging, 59(3), 327-335. http://www.minervamedica.it/en/journals/nuclear-med-molecular-imaging/article.php?cod=R39Y2015N03A0327&acquista=1
    • Retèl, V. P., van den Boer, C., Steuten, L. M. G., Okła, S., Hilgers, F. J., & van den Brekel, M. W. (2015). Cost-effectiveness of heat and moisture exchangers compared to usual care for pulmonary rehabilitation after total laryngectomy in Poland. European Archives of Oto-Rhino-Laryngology, 272(9), 2381-2388. https://doi.org/10.1007/s00405-015-3618-5 [details]
    • Retèl, V. P., van der Molen, L., Steuten, L. M. G., van den Brekel, M. W., & Hilgers, F. J. M. (2015). A cost-effectiveness analysis of using TheraBite in a preventive exercise program for patients with advanced head and neck cancer treated with concomitant chemo-radiotherapy. European Archives of Oto-Rhino-Laryngology, 273(3), 709-718. https://doi.org/10.1007/s00405-015-3541-9 [details]
    • Schoot, R. A., Slater, O., Ronckers, C. M., Zwinderman, A. H., Balm, A. J. M., Hartley, B., van den Brekel, M. W., Gupta, S., Saeed, P., Gajdosova, E., Pieters, B. R., Gaze, M. N., Mandeville, H. C., Davila Fajardo, R., Chang, Y. C., Gains, J. E., Strackee, S. D., Dunaway, D., Abela, C., ... Merks, J. H. M. (2015). Adverse events of local treatment in long term head and neck rhabdomyosarcoma survivors after external beam radiotherapy or AMORE treatment. European Journal of Cancer, 51(11), 1424-1434. https://doi.org/10.1016/j.ejca.2015.02.010 [details]
    • Timmermans, A. J., de Gooijer, C. J., Hamming-Vrieze, O., Hilgers, F. J. M., & van den Brekel, M. W. M. (2015). T3-T4 laryngeal cancer in The Netherlands Cancer Institute: 10-year results of the consistent application of an organ preserving/-sacrificing protocol. Head & Neck, 37(10), 1495-1503. https://doi.org/10.1002/hed.23789 [details]
    • Verhagen, C. V. M., de Haan, R., Hageman, F., Oostendorp, T. P. D., Carli, A. L. E., O'Connor, M. J., Jonkers, J., Verheij, M., van den Brekel, M. W., & Vens, C. (2015). Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of tumor cells. Radiotherapy and oncology, 116(3), 358-365. https://doi.org/10.1016/j.radonc.2015.03.028 [details]
    • Zerp, S. F., Stoter, T. R., Hoebers, F. J., van den Brekel, M. W. M., Dubbelman, R., Kuipers, G., Lafleur, M. V. M., Slotman, B. J., & Verheij, M. (2015). Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancer. Radiation Oncology, 10, [158]. https://doi.org/10.1186/s13014-015-0474-9 [details]
    • de Bree, R., & van den Brekel, M. W. M. (2015). Elective neck dissection versus observation in the clinically node negative neck in early oral cancer: Do we have the answer yet? Oral Oncology, 51(11), 963-965. https://doi.org/10.1016/j.oraloncology.2015.08.013 [details]
    • de Jong, M. C., ten Hoeve, J. J., Grénman, R., Wessels, L. F., Kerkhoven, R., te Riele, H., van den Brekel, M. W. M., Verheij, M., & Begg, A. C. (2015). Pretreatment microRNA Expression Impacting on Epithelial-to-Mesenchymal Transition Predicts Intrinsic Radiosensitivity in Head and Neck Cancer Cell Lines and Patients. Clinical Cancer Research, 21(4), 5630-5638. https://doi.org/10.1158/1078-0432.CCR-15-0454 [details]
    • de Veij Mestdagh, P. D., van den Brekel, M. W. M., & Smeele, L. E. (2015). Robotchirurgie bij hoofd-halskanker. Nederlands tijdschrift voor oncologie, 12(4), 141-147. https://www.ntvo.nl/journal-article/robotchirurgie-bij-hoofd-halskanker/ [details]
    • van Harten, M. C., Hoebers, F. J. P., Kross, K. W., van Werkhoven, E. D., van den Brekel, M. W. M., & van Dijk, B. A. C. (2015). Determinants of treatment waiting times for head and neck cancer in the Netherlands and their relation to survival. Oral Oncology, 51(3), 272-278. https://doi.org/10.1016/j.oraloncology.2014.12.003 [details]
    • van Loon, J. W. L., Smeele, L. E., Hilgers, F. J. M., & van den Brekel, M. W. M. (2015). Outcome of transoral robotic surgery for stage I-II oropharyngeal cancer. European Archives of Oto-Rhino-Laryngology, 272(1), 175-183. https://doi.org/10.1007/s00405-014-2939-0 [details]
    • van Monsjou, H. S., Schaapveld, M., van den Brekel, M. W. M., & Balm, A. J. M. (2015). The epidemiology of head and neck squamous cell carcinoma in The Netherlands during the era of HPV-related oropharyngeal squamous cell carcinoma: Is there really evidence for a change? Oral Oncology, 51(10), 901-907. https://doi.org/10.1016/j.oraloncology.2015.06.011 [details]
    • van den Boer, C., Lansaat, L., Muller, S. H., van den Brekel, M. W. M., & Hilgers, F. J. M. (2015). Comparative ex vivo study on humidifying function of three speaking valves with integrated heat and moisture exchanger for tracheotomised patients. Clinical Otolaryngology, 40(6), 616-621. https://doi.org/10.1111/coa.12426 [details]
    • van den Boer, C., Muller, S. H., van der Noort, V., Valdés Olmos, R. A., Minni, A., Parilla, C., Hilgers, F. J. M., van den Brekel, M. W. M., & van der Baan, S. (2015). Effects of heat and moisture exchangers on tracheal mucociliary clearance in laryngectomized patients: a multi-center case-control study. European Archives of Oto-Rhino-Laryngology, 272(11), 3439-3450. https://doi.org/10.1007/s00405-014-3336-4 [details]

    2014

    • Clapham, R., Middag, C., Hilgers, F., Martens, J-P., van den Brekel, M., & van Son, R. (2014). Developing automatic articulation, voice quality and accent assessment techniques for speakers treated for advanced head and neck cancer. Speech Communication, 59, 44-54. https://doi.org/10.1016/j.specom.2014.01.003 [details]
    • Hilgers, F. J. M., van den Boer, C., van den Brekel, M. W. M., & Muller, S. H. (2014). Pulmonary function and rehabilitation. In E. C. Ward, & C. J. van As-Brooks (Eds.), Head and Neck Cancer: Treatment, Rehabilitation and Outcomes. - 2nd ed. (pp. 401-420). Plural Publishing. [details]
    • Kraaijenga, S. A. C., Van Der Molen, L., Van Den Brekel, M. W. M., & Hilgers, F. J. M. (2014). Current assessment and treatment strategies of dysphagia in head and neck cancer patients: A systematic review of the 2012/13 literature. Current Opinion in Supportive and Palliative Care, 8(2), 152-163. https://doi.org/10.1097/SPC.0000000000000050
    • Paleri, V., Drinnan, M., Van Den Brekel, M. W. M., Hinni, M. L., Bradley, P. J., Wolf, G. T., De Bree, R., Fagan, J. J., Hamoir, M., Strojan, P., Rodrigo, J. P., Olsen, K. D., Pellitteri, P. K., Shaha, A. R., Genden, E. M., Silver, C. E., Suárez, C., Takes, R. P., Rinaldo, A., & Ferlito, A. (2014). Vascularized tissue to reduce fistula following salvage total laryngectomy: A systematic review. Laryngoscope, 124(8), 1848-1853. https://doi.org/10.1002/lary.24619
    • Timmermans, A. J., Lansaat, L., Kroon, G. V. J., Hamming-Vrieze, O., Hilgers, F. J. M., & van den Brekel, M. W. M. (2014). Early oral intake after total laryngectomy does not increase pharyngocutaneous fistulization. European Archives of Oto-Rhino-Laryngology, 271(2), 353-358. https://doi.org/10.1007/s00405-013-2524-y [details]
    • Timmermans, A. J., Lansaat, L., Theunissen, E. A. R., Hamming-Vrieze, O., Hilgers, F. J. M., & van den Brekel, M. W. M. (2014). Predictive factors for pharyngocutaneous fistulization after total laryngectomy. The Annals of Otology Rhinology & Laryngology, 123(3), 153-161. https://doi.org/10.1177/0003489414522972 [details]
    • Van Den Boer, C., Vas Nunes, J. H., Muller, S. H., Van Der Noort, V., Van Den Brekel, M. W. M., & Hilgers, F. J. M. (2014). Water uptake performance of hygroscopic heat and moisture exchangers after 24-hour tracheostoma application. Otolaryngology - Head and Neck Surgery (United States), 150(6), 999-1004. https://doi.org/10.1177/0194599814527420
    • de Ridder, M., Smeele, L. E., van den Brekel, M. W. M., van Harten, M. C., Wouters, M. W. J. M., & Balm, A. J. M. (2014). Volume criteria for the treatment of head and neck cancer: are they evidence based? Head & Neck, 36(5), 760-762. https://doi.org/10.1002/hed.23555 [details]
    • van Harten, M. C., de Ridder, M., Hamming-Vrieze, O., Smeele, L. E., Balm, A. J. M., & van den Brekel, M. W. M. (2014). The association of treatment delay and prognosis in head and neck squamous cell carcinoma (HNSCC) patients in a Dutch comprehensive cancer center. Oral Oncology, 50(4), 282-290. https://doi.org/10.1016/j.oraloncology.2013.12.018 [details]
    • van den Boer, C., Muller, S. H., Vincent, A. D., Züchner, K., van den Brekel, M., & Hilgers, F. J. M. (2014). Ex vivo water exchange performance and short-term clinical feasibility assessment of newly developed heat and moisture exchangers for pulmonary rehabilitation after total laryngectomy. European Archives of Oto-Rhino-Laryngology, 271(2), 359-366. https://doi.org/10.1007/s00405-013-2528-7 [details]
    • van den Boer, C., Muller, S. H., Vincent, A. D., van den Brekel, M. W. M., & Hilgers, F. J. M. (2014). Ex vivo assessment and validation of water exchange performance of 23 heat and moisture exchangers for laryngectomized patients. Respiratory Care, 59(8), 1161-1171. https://doi.org/10.4187/respcare.02840
    • van den Boer, C., van Harten, M. C., Hilgers, F. J. M., van den Brekel, M. W. M., & Retèl, V. P. (2014). Incidence of severe tracheobronchitis and pneumonia in laryngectomized patients: a retrospective clinical study and a European-wide survey among head and neck surgeons. European Archives of Oto-Rhino-Laryngology, 271(12), 3297-3303. https://doi.org/10.1007/s00405-014-2927-4

    2013

    • Clapham, R. P., Van As-Brooks, C. J., Van den Brekel, M. W. M., Hilgers, F. J. M., & Van Son, R. J. J. H. (2013). Automatic tracheoesophageal voice typing using acoustic parameters. Interspeech, 14, 2162-2166. http://www.isca-speech.org/archive/interspeech_2013/i13_2162.html [details]
    • Heukelom, J., Hamming, O., Bartelink, H., Hoebers, F., Giralt, J., Herlestam, T., Verheij, M., van den Brekel, M., Vogel, W., Slevin, N., Deutsch, E., Sonke, J. J., Lambin, P., & Rasch, C. (2013). Adaptive and innovative Radiation Treatment FOR improving Cancer treatment outcomE (ARTFORCE); a randomized controlled phase II trial for individualized treatment of head and neck cancer. BMC Cancer, 13. https://doi.org/10.1186/1471-2407-13-84
    • Hilgers, F. J. M., Lorenz, K. J., Maier, H., Meeuwis, C. A., Kerrebijn, J. D. F., Vander Poorten, V., Vinck, A. S., Quer, M., & van den Brekel, M. W. M. (2013). Development and (pre-) clinical assessment of a novel surgical tool for primary and secondary tracheoesophageal puncture with immediate voice prosthesis insertion, the Provox Vega Puncture Set. European Archives of Oto-Rhino-Laryngology, 270(1), 255-262. https://doi.org/10.1007/s00405-012-1976-9 [details]
    • Jacobi, I., van Rossum, M. A., van der Molen, L., Hilgers, F. J. M., & van den Brekel, M. W. M. (2013). Acoustic Analysis of Changes in Articulation Proficiency in Patients With Advanced Head and Neck Cancer Treated With Chemoradiotherapy. The Annals of Otology Rhinology & Laryngology, 122(12), 754-762. https://doi.org/10.1177/000348941312201205 [details]
    • Lodder, W. L., Gilhuijs, K. G. A., Lange, C. A. H., Pameijer, F. A., Balm, A. J. M., & Van Den Brekel, M. W. M. (2013). Semi-automated primary tumor volume measurements by dynamic contrast-enhanced MRI in patients with head and neck cancer. Head and Neck, 35(4), 521-526. https://doi.org/10.1002/hed.22988
    • Lodder, W. L., Lange, C. A. H., Teertstra, H. J., Pameijer, F. A., Van Den Brekel, M. W. M., & Balm, A. J. M. (2013). Value of MR and CT imaging for assessment of internal carotid artery encasement in head and neck squamous cell carcinoma. International Journal of Surgical Oncology, 2013, [968758]. https://doi.org/10.1155/2013/968758
    • Lodder, W. L., Lange, C. A. H., Van Velthuysen, M. L. F., Hauptmann, M., Balm, A. J. M., Van Den Brekel, M. W. M., & Pameijer, F. A. (2013). Can extranodal spread in head and neck cancer be detected on MR imaging. Oral Oncology, 49(6), 626-633. https://doi.org/10.1016/j.oraloncology.2013.02.010
    • Remmelts, A. J., Hoebers, F. J. P., Klop, W. M. C., Balm, A. J. M., Hamming-Vrieze, O., & van den Brekel, M. W. M. (2013). Evaluation of lasersurgery and radiotherapy as treatment modalities in early stage laryngeal carcinoma: tumour outcome and quality of voice. European Archives of Oto-Rhino-Laryngology, 270(7), 2079-2087. https://doi.org/10.1007/s00405-013-2460-x [details]
    • Timmermans, A. J., Brandsma, D., Smeele, L. E., Rosingh, A. W., van den Brekel, M. W. M., & Lohuis, P. J. F. M. (2013). Cervical osteomyelitis after carbon dioxide laser excision of recurrent carcinoma of the posterior pharyngeal wall. The Annals of Otology Rhinology & Laryngology, 122(4), 273-276. https://doi.org/10.1177/000348941312200410 [details]
    • Van Monsjou, H. S., Lopez-Yurda, M. I., Hauptmann, M., Van Den Brekel, M. W. M., Balm, A. J. M., & Wreesmann, V. B. (2013). Oral and oropharyngeal squamous cell carcinoma in young patients: The Netherlands Cancer Institute experience. Head and Neck, 35(1), 94-102. https://doi.org/10.1002/hed.22935
    • Van Monsjou, H. S., Wreesmann, V. B., Van Den Brekel, M. W. M., & Balm, A. J. M. (2013). Head and neck squamous cell carcinoma in young patients. Oral Oncology, 49(12), 1097-1102. https://doi.org/10.1016/j.oraloncology.2013.09.001
    • van den Boer, C., Muller, S. H., Vincent, A. D., Züchner, K., van den Brekel, M. W. M., & Hilgers, F. J. M. (2013). A novel, simplified ex vivo method for measuring water exchange performance of Heat and Moisture Exchangers for postlaryngectomy pulmonary rehabilitation. Respiratory Care, 58(9), 1449-1458. https://doi.org/10.4187/respcare.02369 [details]
    • van der Molen, L., Kornman, A. F., Latenstein, M. N., van den Brekel, M. W. M., & Hilgers, F. J. M. (2013). Practice of laryngectomy rehabilitation interventions: a perspective from Europe/the Netherlands. Current Opinion in Otalaryngology & Head and Neck Surgery, 21(3), 230-238. https://doi.org/10.1097/MOO.0b013e3283610060 [details]

    2012

    • Clapham, R. P., van der Molen, L., van Son, R. J. J. H., van den Brekel, M., & Hilgers, F. J. M. (2012). NKI-CCRT corpus: speech intelligibility before and after advanced head and neck cancer treated with concomitant chemoradiotherapy. In N. Calzolari, K. Choukri, T. Declerck, M. Uğur Doğan, B. Maegaard, J. Mariani, J. Odijk, & S. Piperidis (Eds.), Proceedings of the Eighth International Conference on Language Resources and Evaluation (LREC'12): 23-25 May, 2012, Istanbul, Turkey (pp. 3350-3355). European Language Resources Association (ELRA). [details]
    • Graveland, A. P., Braakhuis, B. J. M., Eerenstein, S. E. J., de Bree, R., Bloemena, E., de Maaker, M., van den Brekel, M. W. M., Dijk, F., Mesker, W. E., Tanke, H. J., Leemans, C. R., & Brakenhoff, R. H. (2012). Molecular diagnosis of minimal residual disease in head and neck cancer patients. Cellular Oncology, 35(5), 367-375. https://doi.org/10.1007/s13402-012-0097-1 [details]
    • Hilgers, F. J. M., Dirven, R., Wouters, Y., Jacobi, I., Marres, H. A. M., & van den Brekel, M. W. M. (2012). A multicenter, prospective, clinical trial evaluating a novel adhesive baseplate (Provox StabiliBase) for peristomal attachment of postlaryngectomy pulmonary and voice rehabilitation devices. The Laryngoscope, 122(11), 2447-2453. https://doi.org/10.1002/lary.23469 [details]
    • Theunissen, E. A. R., Timmermans, A. J., Zuur, C. L., Hamming-Vrieze, O., de Boer, J. P., Hilgers, F., & van den Brekel, M. W. M. (2012). Total laryngectomy for a dysfunctional larynx after (chemo)radiotherapy. Archives of Otolaryngology Head&Neck Surgery, 138(6), 548-555. https://doi.org/10.1001/archoto.2012.862 [details]
    • van den Brekel, M. W. M., Lodder, W. L., Stel, H. V., Bloemena, E., Leemans, C. R., & van der Waal, I. (2012). Observer variation in the histopathologic assessment of extranodal tumor spread in lymph node metastases in the neck. Head & Neck, 34(6), 840-845. https://doi.org/10.1002/hed.21823 [details]

    2010

    • Hilgers, F. J. M., & van den Brekel, M. W. M. (2010). Vocal and speech rehabilitation following laryngectomy. In P. W. Flint, B. H. Haughey, V. J. Lund, J. K. Niparko, M. A. Richardson, K. T. Robbins, & J. R. Thomas (Eds.), Cummings otolaryngology: head & neck surgery. - 5th ed. (pp. 1594-1610). Mosby Elsevier. [details]
    • Hilgers, F. J. M., Ackerstaff, A. H., Jacobi, I., Balm, A. J. M., Tan, I. B., & van den Brekel, M. W. M. (2010). Prospective clinical phase II study of two new indwelling voice prostheses (Provox Vega 22.5 and 20 Fr) and a novel anterograde insertion device (Provox Smart Inserter). The Laryngoscope, 120(6), 1135-1143. https://doi.org/10.1002/lary.20925 [details]
    • Hilgers, F. J. M., Ackerstaff, A. H., van Rossum, M., Jacobi, I., Balm, A. J. M., Tan, I. B., & van den Brekel, M. W. M. (2010). Clinical phase I/feasibility study of the next generation indwelling Provox voice prosthesis (Provox Vega). Acta Oto-Laryngologica, 130(4), 511-519. https://doi.org/10.3109/00016480903283766 [details]
    • Hilgers, F. J. M., Balm, A. J. M., van den Brekel, M. W. M., & Tan, I. B. (2010). Voice restoration. In M. Remacle, & H. E. Eckel (Eds.), Surgery of larynx and trachea (pp. 245-256). Springer. [details]
    • Karakullukcu, M. B., Lohuis, P. J., van den Brekel, M. W. M., & Hilgers, F. J. M. (2010). Sealing of small postlaryngectomy pharyngocutaneous fistulas with voice prosthesis. The Laryngoscope, 120(10), 1971-1973. https://doi.org/10.1002/lary.21071 [details]

    2008

    • Hilgers, F. J. M., & van den Brekel, M. (2008). Practical tips for voice rehabilitation after pharyngolaryngectomy. In C. R. Cernea, F. L. Dias, D. Fliss, R. A. Lima, E. N. Myers, & W. I. Wei (Eds.), Pearls and pitfalls in head and neck surgery: practical tips to minimize complications (pp. 96-97). Karger. [details]
    • Hilgers, F. J. M., Soolsma, J., Ackerstaff, A. H., Balm, F. J. M., Tan, I. B., & van den Brekel, M. W. M. (2008). A thin tracheal silicone washer to solve periprosthetic leakage in laryngectomies: direct results and long-term clinical effects. The Laryngoscope, 118(4), 640-645. https://doi.org/10.1097/MLG.0b013e31816067d5 [details]
    • Soolsma, J., van den Brekel, M. W., Ackerstaff, A. H., Balm, A. J., Tan, B., & Hilgers, F. J. (2008). Long-term results of Provox ActiValve, solving the problem of frequent Candida - and 'underpressure'-related voice prosthesis replacements. The Laryngoscope, 118(2), 252-257. https://doi.org/10.1097/MLG.0b013e318159ebde [details]
    • van den Brekel, M., & Hilgers, F. J. M. (2008). Preoperative workup of the neck in Head and Neck Squamous Cell Carcinoma. In C. R. Cernea, F. L. Dias, D. Fliss, R. A. Lima, E. N. Myers, & W. I. Wei (Eds.), Pearls and pitfalls in head and neck surgery: practical tips to minimize complications (pp. 34-35). Karger. [details]

    2007

    • Menger, D. J., van den Brekel, M. W. M., & Hilgers, F. J. M. (2007). Een bijzonder beloop van een glottisch larynxcarcinoom. Nederlands tijdschrift voor Keel- Neus- en Oorheelkunde, 2007(13), 151-154. [details]

    2006

    • Hilgers, F. J. M., Balm, A. J. M., van den Brekel, M. W. M., & Tan, I. B. (2006). Problembehandlung bei der prothetischen Stimmrehabilitation nach (totaler) Laryngektomie. Journal der Deutschen Gesellschaft für Plastische und Wiederherstellungschirurgie, 33, 41-51. [details]

    2016

    • Muller, S. H., van den Brekel, M. W. M., & Hilgers, F. J. M. (2016). Letter to the editor regarding: The effect of cloth stoma covers on tracheal climate of laryngectomy patients. Head & Neck, 38(2), 330-331. https://doi.org/10.1002/hed.24251 [details]

    2015

    • Paleri, V., Drinnan, M., van den Brekel, M. W. M., Takes, R. P., Rinaldo, A., & Ferlito, A. (2015). In response to Vascularized tissue to reduce fistula following salvage total laryngectomy: A systematic review. The Laryngoscope, 125(4), E156. https://doi.org/10.1002/lary.25018 [details]

    2011

    • Balm, A. J. M., van den Brekel, M. W. M., Tan, I. B., & Hilgers, F. J. M. (2011). The indwelling voice prosthesis for speech rehabilitation after total laryngectomy: a safe approach. Otolaryngologia polska = Polish journal of otolaryngology, 65(6), 402-409. [details]
    • Clapham, R., Hilgers, F., van den Brekel, M., & van Son, R. (2011). An exploration into automatic phonological feature evaluation of tracheoesophageal speech. In W. Zonneveld, H. Quené, & W. Heeren (Eds.), Sound and sounds: studies presented to M.E.H. (Bert) Schouten on the occasion of his 65th birthday (pp. 69-79). Utrecht Institute of Linguistics OTS. [details]

    2008

    • Hilgers, F. J. M., Pols, L. C. W., van Rossum, M., & van den Brekel, M. W. M. (2008). Proceedings Invitational Round Table "Evidence-based Voice and Speech Rehabilitation in Head and Neck Cancer" : May 15-16, 2008, Amsterdam. Netherlands Cancer Institute. [details]

    2021

    • Berger, D. M. S., van den Berg, N. S., van der Noort, V., van der Hiel, B., Valdés Olmos, R. A., Buckle, T., KleinJan, G. H., Brouwer, O. R., Vermeeren, L., Karakullukçu, B., van den Brekel, M. W. M., van de Wiel, B. A., Nieweg, O. E., Balm, A. J. M., van Leeuwen, F. W. B., & Klop, W. M. C. (2021). Technologic (r)evolution leads to detection of more sentinel nodes in patients with melanoma in the head and neck region. The Journal of Nuclear Medicine, 62(10), 1357-1362. https://doi.org/10.2967/jnumed.120.246819

    2015

    • Hilgers, F. J. M., & van den Brekel, M. W. M. (2015). Vocal and Speech Rehabilitation Following Laryngectomy. In P. W. Flint, B. H. Haughey, V. Lund, J. K. Niparko, K. T. Robbins, J. Regan Thomas, & M. M. Lesperance (Eds.), Cummings Otolaryngology - Head & neck surgery. - 6th ed. - Vol. 2 (pp. 1732-1750). Elsevier. [details]
    • Kraaijenga, S. A. C., van den Brekel, M. W. M., Smeele, L. E., & Lapid, O. (2015). Herstel van slik- en stemfunctie met behulp van lipofilling in de mond- of keelholte na behandeling voor hoofd- halskanker. Nederlands Tijdschrift voor Plastische Chirurgie, 6(1), 31-36. http://www.nvpc.nl/uploads/nummer_file/file-190NTPC_2015__6(1)_p31-6_Kraaijenga.pdf [details]

    2014

    • Hilgers, F. J. M., Tan, I. B., & van den Brekel, M. W. M. (2014). Comprehensive (prosthetic) voice, pulmonary and olfaction rehabilitation after total laryngectomy. In Head and Neck Surgery. - 2nd ed. Chris de Souza,Jaypee Brothers Medical Publishers (P) LTD.

    2013

    • Hilgers, F. M., Muller, S. H., Scheenstra, R. J., & van den Brekel, M. (2013). Aktuelle Forschung zur Verbesserung der Wärme und Feuchtigkeitskapazität von HME. In K. Lorenz (Ed.), Pulmonale Rehabilitation nach Laryngektomie (pp. 43-52). (UNI-MED science). UNI-MED-Verlag. [details]

    2012

    • Ackerstaff, A., Hilgers, F. M., & van den Brekel, M. (2012). Bedeutung von HME für die ganzheitliche Rehabilitation nach LE. In K. J. Lorenz (Ed.), Pulmonale Rehabilitation nach Laryngektomie (pp. 35-41). (UNI-MED science). UNI-MED-Verlag. [details]
    • Hilgers, F. J. M., & van den Brekel, M. (2012). Practical tips for voice rehabilitation after pharyngolaryngectomy. In R. C. Claudio (Ed.), Pearls and pitfalls in head and neck surgery: practical tips to minimize complications. - 2nd ed. (pp. 94-95). Karger. [details]
    • Timmermans, A. J., Krap, M., Hilgers, F. J. M., & van den Brekel, M. W. M. (2012). Spraakrevalidatie na een totale laryngectomie. Nederlands Tijdschrift voor Tandheelkunde, 119(7-8), 357-361. https://doi.org/10.5177/ntvt.2012.07/08.12132 [details]
    • Timmermans, A. J., van den Brekel, M. W. M., van der Molen, L., Navran, A., Nijssen, T. F., & Hilgers, F. J. M. (2012). Nieuwe ontwikkelingen in behandeling en revalidatie bij hoofd-halskanker. Nederlands Tijdschrift voor Geneeskunde, 156(41), 1719-1724. [A5059]. [details]
    • van den Brekel, M. (2012). Hoofd-hals oncologie onder spanning. Amsterdam: University of Amsterdam, Amsterdam Center for Language and Communication. [details]

    2015

    • Zaim, R., van der Putten, L., de Groot, S., van Tinteren, H., Boers, M., Comans, E. F., Laan, B., Janssen, L., Takes, R. P., van den Brekel, M. W. M., Oyen, W., Valdes-Olmos, R. A., Hobbelink, M. G., Wedman, J., Leemans, C. R., Hoekstra, O., de Bree, R., & Uyl-de Groot, C. A. (2015). Recurrent laryngeal carcinoma Pet study (Relaps): Cost analysis of 18f-Fdg Pet in patients with suspected recurrent laryngeal cancer previously treated with radiotherapy. Value in Health, 18(7), [A353]. https://doi.org/10.1016/j.jval.2015.09.652

    2017

    • Clapham, R. P. (2017). Automatic evaluation of voice and speech intelligibility after treatment of head and neck cancer. [details]
    This list of publications is extracted from the UvA-Current Research Information System. Questions? Ask the library or the Pure staff of your faculty / institute. Log in to Pure to edit your publications. Log in to Personal Page Publication Selection tool to manage the visibility of your publications on this list.
  • Ancillary activities
    • KNO Vereniging Nederland
      Bestuurslid, portefeuille wetenschap
    • AMC Amsterdam
      KNO arts
    • NKL-AVL Amsterdam
      Hoofd-hals chirurg