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Dr. J.C. (Hans) van der Spek

Faculty of Science
Swammerdam Institute for Life Sciences
Photographer: onbekend

Visiting address
  • Science Park 904
  • Room number: C3.262
Postal address
  • Postbus 94232
    1090 GE Amsterdam
  • Profile

    General information

    I am assistant professor in the group 'Molecular Biology and Microbial Food Safety' headed by Prof Stanley Brul at the Swammerdam Institute for Life Sciences (SILS) at the University of Amsterdam (UvA). For a general description of the research interests of the group refer to:

    The group: SILS/MB&MFS Staff: Prof. dr Stanley Brul Staff: dr Gertien Smits

    Personal research interest

    My personal research interest is on mitochondrial genetics and function (yeast, man, nematodes), including topics like regulation of translation, respiratory complex assembly and regulation of transcription (mainly in bakers yeast). Recently the focus has shifted to anti-retroviral drug-induced mitochondrial dysfunction that has become apparent in HIV-1 infected patients (see below). To address fundamental questions concerning mitochondrial (dys)function the nematode Caenorhabditis elegans has been introduced in the lab and employed as a  model organism.  For an overview of recent results follow the link to see the poster presented at the SILS researchday in January 2008.
    Additional research activities are supervision of fundamental and applied research projects concerning food spoilage microorganisms such as Bacillus subtilis .

    Student Projects

    Within our 'mitochondrial (dys)function' group (staff, PhD student and a technician) there are possibilities for Bachelor-, Master- and HBO students to perform a research project. For a general description of the research project follow the link. For more information contact Hans van der Spek.

    Publications

    Follow the link to see the publications.

    Publications via DARE (not complete)
  • Publications

    2017

    • Smith, R. L., Tan, J. M. E., Jonker, M. J., Jongejan, A., Buissink, T., Veldhuijzen, S., ... van der Spek, H. (2017). Beyond the polymerase-Ī³ theory: Production of ROS as a mode of NRTI-induced mitochondrial toxicity. PLoS ONE, 12(11), [e0187424]. https://doi.org/10.1371/journal.pone.0187424 [details]

    2015

    2013

    2004

    • Lascaris, R., Piwowarski, J., van der Spek, H., Teixeira de Mattos, J., Grivell, L., & Blom, J. (2004). Overexpression of HAP4 in glucose-derepressed yeast cells reveals respiratory control of glucose-regulated genes. Microbiology - SGM, 150(4), 929-934. https://doi.org/10.1099/mic.0.26742-0
    This list of publications is extracted from the UvA-Current Research Information System. Questions? Ask the library or the Pure staff of your faculty / institute. Log in to Pure to edit your publications. Log in to Personal Page Publication Selection tool to manage the visibility of your publications on this list.
  • Ancillary activities
    • No ancillary activities