I am assistant professor in the group 'Molecular Biology and Microbial Food Safety' headed by Prof Stanley Brul at the Swammerdam Institute for Life Sciences (SILS) at the University of Amsterdam (UvA). For a general description of the research interests of the group refer to:
My personal research interest is on mitochondrial genetics
and function (yeast, man, nematodes), including topics like
regulation of translation, respiratory complex assembly and
regulation of transcription (mainly in bakers yeast). Recently
the focus has shifted to anti-retroviral drug-induced
mitochondrial dysfunction that has become apparent in HIV-1
infected patients (see below). To address fundamental questions
concerning mitochondrial (dys)function the nematode
Caenorhabditis elegans has been introduced in the lab
and employed as a model organism. For an overview of recent
results follow the link to see the poster presented at the SILS
researchday in January 2008.
Additional research activities are supervision of fundamental and applied research projects concerning food spoilage microorganisms such as Bacillus subtilis .
Within our 'mitochondrial (dys)function' group (staff, PhD student and a technician) there are possibilities for Bachelor-, Master- and HBO students to perform a research project. For a general description of the research project follow the link. For more information contact Hans van der Spek.
Follow the link to see the publications.