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NL

dr. L.M. (Lucia) Talamini

Faculty of Social and Behavioural Sciences
Programme group Brain and Cognition
Photographer: onbekend

Visiting address
  • Nieuwe Achtergracht 129
  • Room number: 0.08
Postal address
  • Postbus 15915
    1001 NK Amsterdam
  • Profile

    Biographical Sketch

    I received my master's degree in Biology in 1991 (Univ. of Leiden; specializations in Medical Biology and Neurobiology). Over the following 3 years I worked on growth factor-induced neural plasticity (Inst. of Neurobiology, Rome, with L. Aloe and R. Levi-Montalcini) and NMDA receptor plasticity (Univ. of Amsterdam, with W. Kamphuis and F. Lopez Da Silva). I obtained my PhD in 2000 (Univ. of Groningen), developing an animal model that implicates abnormal mediotemporal lobe (MTL) development in the pathogenesis of schizophrenia, and links cognitive symptomatology to MTL pathology (with J. Korf).

    In 1999, I joined the Brain and Cognition dept. at the University of Amsterdam, to further investigate the relation between MTL structure and function through neural network modelling (with J. Murre and M. Meeter). These models were, moreover, used to assess the relation between MTL abnormalities and cognitive dysfunction in several disorders, including schizophrenia, depression and amnesia.

    In 2002 I left the department, to work as team leader and cognition specialist in schizophrenia drug discovery, at Johnson & Johnson Pharmaceutical R&D. In 2004 I returned to my present affiliation and memory research, using imaging techniques to probe the human brain.

    I have been awarded several personal research grants, including a VIDI grant, and have published widely in the fields of memory, schizophrenia, neural network modelling and the role of sleep in memory reorganisation.

     

    Research theme

    The main goal of the 'Memory and Sleep' group is to understand memory processes and their neural underpinnings. We study these processes not only in the awake brain, but also during sleep. Indeed, it appears that when the brain is asleep, and relatively insensitive to external stimuli, processing of stored memories continues. Such 'offline' processing is of great importance to awake functioning.

     

    Specific research topics

    A long-time topic concerns the reorganisation of memory over time and sleep. Within this program we investigate post-encoding memory processes (e.g. consolidation, generalisation, recombination, emotional down-tuning), their neural underpinnings, and their differential dependence on sleep and wake states. Clinically oriented studies concern the characterization of memory processing deficits or sleep problems in psychological and neurological disorders. Furthermore, we investigate sleep problems as a risk factor in the aetiology of affective disorders, including post-traumatic stress disorder (PTSD) and depression. We adopt a multi-disciplinary approach, involving experimentation supported by cutting edge electrophysiological and MRI-based techniques, as well as computational modelling, to bridge the gap between brain and behaviour.

    Fundamental topics

    - Mediotemporal lobe computations underlying memory function

    - From episodic memories to general knowledge

    - Tracing memory reactivation in the sleeping brain

    - Memory implantation during sleep

    - Oscillatory dynamics of the sleeping brain

    - Local sleep phenomena and twilight states

    - Constructive (i.e. creative) processing and problem solving during sleep

    - Interplay between sleep and emotion

    Clinical topics

    - Role of sleep problems in PTSD and other affective disorders

    - Characterising sleep abnormalities in post-traumatic stress disorder

    - Are sleep problems related to maladaptive emotional memory processing?

    - Are sleep problems related to maladaptive emotional regulation?

     

    Selected publications

    Roy Cox, Joram van Driel, Marieke de Boer & Lucia M Talamini. Slow oscillations during sleep coordinate interregional communication in cortical networks. J. Neurosci, 2014, 34(50):16890 –16901.

    Carly C. G. Sweegers & Lucia M. Talamini. Generalization from episodic memories across time: a route for semantic knowledge acquisition. Cortex, 2014, 59C:49-61.

    Roy Cox, Winni F. Hofman, Marieke de Boer & Lucia M. Talamini. (2014) Local sleep spindle modulations in relation to specific memory cues. Neuroimage, Oct;99: 103–110.

    Cox R, Korjoukov I, de Boer M & Talamini LM (2014). Sound asleep: Processing and retention of slow oscillation phase-targeted stimuli. PLoS One 9(7), e101567.

    Carly C.G. Sweegers, Atsuko Takashima, Guillén Fernández & Lucia M. Talamini. (2014) Neural mechanisms supporting the extraction of general knowledge across episodic memories. NeuroImage Feb 15;87:138-46.

    Lucia M. Talamini, Laura F. Bringmann, Marieke de Boer & Winni F. Hofman. (2013) Sleeping worries away or worrying away sleep? Physiological evidence on sleep-emotion interactions. PLoS ONE 8(5): e62480.

    Roy Cox, Winni F. Hofman & Lucia M. Talamini (2012). Involvement of spindles in memory consolidation is slow wave sleep-specific. Learn Mem. 19(7):264-7.

    Lucia M. Talamini and Eva Gorree (2012). Ageing memories: differential decay of episodic memory components. Learning and Memory. Learn Mem. 19(6):239-46.

    Atsuko Takashima, Ingrid Nieuwenhuis, Ole Jensen, Lucia Talamini, Mark Rijpkema, Guillen Fernandez. (2009) Shift from hippocampal to neocortical centered retrieval network with consolidation. J. Neurosci., 29(32):10087-93.

    Lucia M. Talamini, Ingrid L.C. Nieuwenhuis, Atsuko Takashima and Ole Jensen. (2008) Sleep directly following learning benefits consolidation of spatial associative memory. Learning and Memory. 15(4):233-7.

    Meeter M., Riedel W., Schmitt, Talamini L.M. (2006) Effects of 5-HT on memory and the hippocampus: model and data. Neuropsychopharmacology 31(4):712-20.

    Lisman JE, Talamini LM, Raffone A. (2005) Recall of memory sequences by interaction of the dentate and CA3: A revised model of the phase precession. Neural Netw. 18: 1191-1201.

    Talamini L.M., Meeter M., Elvevåg B., Murre J.M.J., & Goldberg T.E. (2005) Reduced parahippocampal connectivity produces schizophrenia-like memory deficits in simulated neural circuits. Arch Gen Psychiatry. 62(5):485-93.

    Meeter M., Murre J.M. J. and Talamini L.M. (2004) Mode shifting between storage and recall based on novelty detection in oscillating hippocampal circuits. Hippocampus, 14, 722-41.

    Talamini L.M., Meeter M. and Murre J.M.J. (2003) Combating fuzziness with computational modeling. Behavioral and Brain Sciences, 26, 107-108

    Talamini L.M., Ellenbroek B., Koch T. and J. Korf. (2000) Impaired sensory gating and attention in rats with developmental abnormalities of the mesocortex. Ann. New York Acad. Sci. 911, 486-495.

     

    Selected book contributions

    Hofman W.F. and Talamini L.M. Normal sleep and its neurophysiological regulation. In: Sleep Modulation By Obesity, Diabetes, Age And Diet (ed. R. Watson). Elsevier, September 2014.

    Talamini L.M. and van der Werf Y. Slaap en geheugen. In: Handboek Slaap (eds. J. Verbraecken, B. Buyse, H. Hamburger, V. van Kasteel en R. van Steenwijk). Uitgeverij ACCO. In preparation.

    Talamini L.M. Slapen en Breinleren. In: Breinboek voor opleiders (eds. N. Lazeron en R. van Dinteren). Bohn Stafleu van Loghum te Houten, 2010.

  • Publications

    2019

    • Talamini, L. M., van der Werf, Y., & Hofman, W. F. (2019). Sekseverschillen in slaap en slaap-waak stoornissen. Manuscript in preparation. In Handboek psychopathologie bij vrouwen en mannen. : Van 0 tot 100+ (Handboek psychopathologie bij vrouwen en mannen. Van 0 tot 100+ ). Academic Publishers.

    2018

    • Perdomo, V. L., Hofman, W. F., & Talamini, L. M. (2018). Sleep Fosters Insight Into Real-Life Problems. Archives Italiennes de biologie, 156(3), 87-98. https://doi.org/10.12871/aib.v156i3.4645 [details]
    • Talamini, L. M., Nijdam, M. J., de Boer, M., Jongedijk, R. A., Olff, M., & Hofman, W. F. (Accepted/In press). W.F. Sleep Power in Post-Traumatic Stress Disorder. Psychotherapy and Psychosomatics.
    • Wassing, R., Benjamins, J. S., Talamini, L. M., Schalkwijk, F., & van Someren, E. J. W. (2018). Overnight worsening of emotional distress indicates maladaptive sleep in insomnia. Sleep. https://doi.org/10.1093/sleep/zsy268
    • Wassing, R., Schalkwijk, F., Kamal, O., Ramautar, J. R., Stoffers, D., Mutsaerts, H. J. M. M., ... Talamini, L. M. (2018). Haunted by the past: old emotions remain salient in insomnia disorder. Manuscript in preparation.

    2015

    2014

    2013

    2012

    2010

    2009

    2008

    • Talamini, L. M., Nieuwenhuis, I. L. C., Takashima, A., & Jensen, O. (2008). Sleep directly following learning benefits consolidation of spatial associative memory. Learning & Memory, 15(4), 233-237. https://doi.org/10.1101/lm.771608 [details]

    2018

    • Talamini, L. M., & Olcese, U. (2018). Special issue: Crossing the watershed between sleep and wakefulness: Collection of selected contributions from the 2017 Amsterdam Brain and Cognition Symposium. Archives Italiennes de biologie, 156(3), 87-148.

    2016

    • Talamini, L. M., de Boer, M., Nijdam, M. J., Jongedijk, R. A., Olf, M., & Hofman, W. F. (2016). Spatially specific changes in EEG spectral power in post traumatic stress disorder during REM and NREM sleep. Journal of Sleep Research, 25(1, Supplement), 371-372. [P897]. https://doi.org/10.1111/jsr.12446 [details]
    • Talamini, L. M., van der Heijden, A. C., Kumar, A., de Boer, M., Nijdam, M. J., Jongedijk, R. A., ... Hofman, W. F. (2016). Sigma fluctuations in police officers and combat veterans with PSTD. Journal of Sleep Research, 25(1, Supplement), 372. [P898]. https://doi.org/10.1111/jsr.12446 [details]
    • Talamini, L. M., van der Heijden, A. C., Kumar, A., de Boer, M., Nijdam, M. J., Jongedijk, R. A., ... Hofman, W. F. (2016). Sigma fluctuations in police officers and combat veterans with PTSD. Sleep-Wake Research in the Netherlands, 27, 56. [details]

    2015

    • Kumar, A., Hofman, W. F., & Talamini, L. M. (2015). Time variant spindle dynamics using statistical signal analysis. Sleep-Wake Research in the Netherlands, 26, 67. [details]

    2011

    • Bringmann, L. F., Hofman, W. F., & Talamini, L. M. (2011). The effect of emotional stimuli on sleep architecture in healthy subjects. Sleep-Wake Research in the Netherlands, 22, 40-43. [details]
    • Cox, R., Hofman, W. F., & Talamini, L. M. (2011). Retention-dependent increases in sleep spindle density: a specific SWS phenomenon. Sleep-Wake Research in the Netherlands, 22, 48-51. [details]

    2018

    • Talamini, L. M. (2018). Assembly, method and computer program product for influencing a biological process. (Patent No. 2018435).
    • Talamini, L. M. (2018). Device for evaluating brain signals. (Patent No. 2018442).

    2012

    • Talamini, L. M., & van der Werf, Y. D. (2012). De rol van slaap in cognitie en affect. Tijdschrift voor Neuropsychologie, 7(3), 122-129. [details]

    2010

    2013

    • Nijdam, M. J., de Boer, M., Hofman, W. F., Talamini, L. M., & Olff, M. (2013). The role of sleep in emotional memory processing in PTSD patients. Poster session presented at International Society for Trauma and Stress Studies (ISTSS), .
    • Talamini, L. M., Cox, R., Sweegers, C. C. G., & Hofman, W. F. (2013). Effects of emotional experience on sleep deped on circadian phase. Paper presented at Society for Neuroscience (SFN), .
    • Talamini, L. M., Cox, R., Sweegers, C. C. G., & Hofman, W. F. (2013). Effects of emotional experience on sleep depend on circadian phase. Paper presented at European Brain and Behavior Society (EBBS), .

    2016

    • Talamini, L. M., de Boer, M., Nijdam, M. J., Jongedijk, R. A., Olff, M., & Hofman, W. F. (2016). Spatially specific changes in EEG spectral power in post traumatic stress disorder during REM en NREM sleep. Sleep-Wake Research in the Netherlands, 27, 55.

    2014

    • Hofman, W. F., de Boer, M., Nijdam, M. J., Jongedijk, R. A., Olf, M., & Talamini, L. M. (2014). Sleep structure and emotional memory processing in police officers and combat veterans with PTSD. Sleep-Wake Research in the Netherlands, 25, 110.
    • de Boer, M., Nijdam, M. J., Hofman, W. F., Jongedijk, R. A., Olff, M., & Talamini, L. M. (2014). Sleep disturbances and emotional memory processing in PTSD patients. Sleep, 37(abstract supplement), A272.

    2013

    Award

    • Talamini, L. M. (2018). NWO-STW beurs "A neurotech solution for sleep and memory improvement" 40kE.
    • Talamini, L. M. (2018). ESA ARIADNE beurs "Improving sleep-stability through sleep spindle induction" 40kE.
    • Talamini, L. M. (2018). APCA beurs “Validation of a PTSD neuromarker” 45kE.
    • Talamini, L. M. (2018). APCA beurs “Sleep improvement through closed-loop neurostimulation” 45kE.

    Membership

    • Talamini, L. M. (2010). Collaboration with M. Meeter, Hippocampal modeling., Cognitive Psychology, VU.
    • Talamini, L. M. (2010). Collaboration with W. Hofman and J. Murre (UvA), O. Jensen, G. Fernandez, A. Takashima and I. Nieuwenhuis (F.C Donders centre for Cognitive (…), UvA, F.C Donders centre for Cognitive Neuroimaging, Nijmegen,Depts. of Psychology and Physiology, Univ. of Arizona.

    Media appearance

    • Talamini, L. M. (31-03-2018). De schommel van de slaap Elsevier Weekblad. De schommel van de slaap; Met nieuwe techniek kunnen wetenschappers slaap verdiepen en tegelijk het geheugen manipuleren. Is herinneringen wissen de volgende stap?.
    • Talamini, L. M. (25-02-2018). Interview over slaap en geheugen boosting tijdens slaap Radio 538. Interview over slaap en geheugen boosting tijdens slaap.
    • Talamini, L. M. (24-02-2018). “Slapend leren met behulp van geheugenimplantatie” Radio 1 Nieuwsweekend. “Slapend leren met behulp van geheugenimplantatie”.
    • Talamini, L. M. (24-02-2018). "Zo kun je slapend slim worden" Algemeen Dagblad. "Zo kun je slapend slim worden".
    • Talamini, L. M. (21-02-2018). "Zo kun je slapend slim worden" Het Parool. "Zo kun je slapend slim worden".

    Journal editor

    • Talamini, L. M. (editor) (2010). The Open Behavioral Science Journal (Journal).

    Talk / presentation

    • Talamini, L. M. (speaker) (11-5-2018). The Hidden Processing Potential of the Sleeping Brain, INPP conference, Madrid, Spain.
    • Talamini, L. M. (speaker) (13-2-2018). Wat is echt in het geheugen?, Fähig #10 – Salons over levenskunst | ECHT .
    • Talamini, L. M. (invited speaker) (13-9-2016). Memory-related cross-brain communication during sleep, ESRS symposium, ESRS conference, Bologna.
    • Talamini, L. M. (invited speaker) (13-9-2016). Memory Manipulation During Sleep: Fundamental Advances and Clinical Applications, ESRS symposium - ESRS conference, Bologna.
    • Talamini, L. M. (invited speaker) (10-5-2016). Sleep and Cognition Event, Sleep and Cognitiotn Event, Amsterdam.
    • Talamini, L. M. (invited speaker) (14-4-2015). Learning Memory and Sleep, Evening about Forgetting by Jeroen Busscher, Amsterdam.
    • Talamini, L. M. (invited speaker) (8-10-2014). Hersenontwikkeling in de klas, Lerarencongres, Den Bosch.
    • Talamini, L. M. (invited speaker) (16-9-2014). ASRS, Chair and opening lecture: symposium on Learning, Memory and Cognition, Tallinn, Estonia.
    • Talamini, L. M. (invited speaker) (2-4-2014). Brain Slicing Event, Yearly brain dissection workshop, held during spring in Amsterdam., Amsterdam.
    • Talamini, L. M. (invited speaker) (18-3-2014). Memory processing during sleep; from brain to behaviour, Plenary lecture, SFB Meeting on Sleep and Plasticity, Tübingen.
    • Talamini, L. M. (invited speaker) (2014). Interregional communication in sleeping cortical networks, Lecture at 2nd Winter-Symposium "Sleep, Cognition and Consciousness, Salzburg.

    Others

    • Talamini, L. M. (participant) (13-9-2018 - 14-9-2018). - Chair for Neural Memory Replay session (other).
    • Cox, R. (organiser) & Talamini, L. M. (organiser) (18-6-2014). Neural mechanisms linking sleep and memory, Amsterdam (organising a conference, workshop, ...).
    This list of publications is extracted from the UvA-Current Research Information System. Questions? Ask the library or the Pure staff of your faculty / institute. Log in to Pure to edit your publications. Log in to Personal Page Publication Selection tool to manage the visibility of your publications on this list.
  • Ancillary activities
    • No ancillary activities